of surface plasmons with an incoherent light source and the detection with a portable spectrometer; however, the sensitivity of these devices is an order of magnitude lower than conventional SPR sensors. [7] Here, we report a new nanoplasmonic resonance sensor design that shows a unique interactive plasmonic-photonic resonance effect: only resonance peak intensity variation, not a plasmon resonance wavelength shift, is observed in the far field as a function of the optical refractive index (RI) on the superstrate when a periodic plasmonic nanostructure and a multilayer nanocavity are combined. Multilayer plasmonic structures have been investigated for on-chip photonic devices, such as multilayered plasmonic waveguides. [8] Metal-insulator-metal (MIM) surface plasmon waveguides have been studied for refractometric detection. [9] In addition, the localized surface plasmon resonance (LSPR) effect has been used with multilayered geometries to increase light-induced catalytic activity of materials such as palladium. [10] The study of dielectric films and MIM structures combined with an EOT substrate has been reported previously. [11] However, these prior works focused on surface enhanced Raman spectroscopy applications or on the plasmon resonance peak shift of nanohole arrays and the sensitivity of these structures to superstrate RI changes was lower than conventional EOT devices.The new hybrid nanoplasmonic-nanocavity sensor that we utilize here is based on a 3D plasmonic nanocup resonator structure, which consists of a nanostructured polymer substrate with a deposited gold (Au) layer. [12] To form a nanocavity A sensor design and sensing method based on plasmonic-photonic interactions that occur when a nanocavity array is embedded in a 3D tapered nanocup plasmonic substrate are reported. This device enables highly sensitive detection of refractive index changes based on changes to the transmission peak intensity without shift in the resonance wavelength. Unlike conventional plasmonic sensors, there is a consistent and selective change in the transmission intensity at the resonance peak wavelength with no spectral shift. In addition, there are wavelength ranges that show no intensity change, which can be used as reference regions. The fabrication and characterization of the plasmonic nanocavity sensor are described and also advanced biosensing is demonstrated. Simulations are carried out to better understand the plasmon-photonic coupling mechanism. This nanocavity plasmonic sensor design has a limit of detection of 1 ng mL −1 (5 × 10 −12 m) for the cancer biomarker carcinoembryonic antigen (CEA), which is a significant improvement over current surface plasmon resonance systems, and a dynamic range that is clinically relevant for human CEA levels.