Enhancement of long‐term potentiation in the rat dentate gyrus by post‐trial stimulation of the reticular formation.

Bloch,; Laroche, Serge

doi:10.1113/jphysiol.1985.sp015613

Cited by 27 publications

(6 citation statements)

References 42 publications

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“…For example, LTP in the dentate gyrus decays more quickly in old than in young rats (Barnes, 1979), and the difference in LTP decay rates is similar to the difference observed between old and young rats in their forgetting rates of spatial information (Barnes and McNaughton, 1985). Furthermore, postevent electrical stimulation of the mesencephalic reticular formation, a maneuver that facilitates memory (e.g., Deweer, 1976;Dekeyne et al, 1987), has been shown to facilitate and prolong LTP in the dentate gyrus (Bloch and Laroche, 1985) and to promote long-term maintenance of hippocampal associative cell responses to a CS in classical conditioning (Bloch and Laroche, 1981). In addition, protein synthesis inhibitors prevent the formation of longterm memory (see Gibbs and Ng, 1977;Dunn, 1980;Rosenzweig and Bennett, 1984, for reviews) and suppress the late phases of LTP in the dentate gyrus (Krug et al, 1984;Otani et al, 1989).…”

Section: Discussionmentioning

confidence: 58%

Linear relationship between the maintenance of hippocampal long‐term potentiation and retention of an associative memory

Doyère

Laroche

1992

Hippocampus

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The hypothesis that the maintenance or decay of an associative memory trace after an extended retention interval is a function of the residual strength of the synapses originally strengthened during learning was examined in a classical conditioning paradigm in which high-frequency stimulation of a hippocampal input--the medial perforant path--served as a conditioned stimulus. Rats received perforant path stimulus-foot shock pairings while engaged in a previously acquired food-motivated lever-pressing task. Conditioned suppression of lever pressing was the behavioral measure of learning and retention of the association. Stimulus trains to the perforant path at an intensity above the threshold for eliciting a population spike induced long-term potentiation of synaptic transmission in the dentate gyrus. Synaptic potentials recorded extracellularly in the dentate gyrus were subsequently monitored for 31 days to examine quantitatively the decay of synaptic potentiation, a period after which retention of the learned association was assessed. All rats learned the association to a similar extent and displayed equivalent amounts of long-term potentiation by the end of conditioning. A slowly decaying function of synaptic potentiation was observed in remembering rats, i.e., rats with high retention performance after the 31-day learning-to-retention interval, while forgetting was associated with a rapid decay of long-term potentiation. Behavioral performance at the long-term memory test was linearly correlated with the amplitude of long-term potentiation maintained just prior to the retention test. The results favor the hypothesis that long-term associative memory depends, at least in part, on the maintenance of elevated synaptic strengths in the pathway activated during learning and suggest a role for the lasting component of long-term potentiation in the maintenance of memory.

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Section: Discussionmentioning

confidence: 58%

Linear relationship between the maintenance of hippocampal long‐term potentiation and retention of an associative memory

Doyère

Laroche

1992

Hippocampus

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“…All of the tetanization parameters were otherwise identical. Indeed, it is noteworthy that many other previous studies using relatively short baselines also found dentate LTP to be decremental (Racine et al, 1983;Bloch and Laroche, 1985; de Jonge and Racine, 1985). To confirm that the length of the baseline recordings on the day of tetanization was a crucial protocol difference, three additional animals were given the short-baseline 50T paradigm.…”

Section: Sensitivity Of Stable Ltp To Variables On the Day Of Tetanizmentioning

confidence: 89%

Induction and Experience-Dependent Consolidation of Stable Long-Term Potentiation Lasting Months in the Hippocampus

et al. 2002

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Long-term potentiation (LTP) is widely regarded as a memory mechanism, but it is not known whether it can last long enough to underlie very long-term memory. We report that high-frequency stimulation (HFS) paradigms applied to the rat dentate gyrus can elicit stable LTP lasting months and up to at least 1 year. The induction of stable LTP was sensitive to stimulation variables on the day of HFS and was associated with phosphorylation of cAMP response element-binding protein. The maintenance of stable LTP was also experience-dependent, because it was reversed when animals were exposed repeatedly to an enriched environment beginning 14 d post-HFS. However, stable LTP eventually consolidated over time and became resistant to reversal, because exposure to enriched environments 90 d post-HFS failed to influence stable LTP maintenance. Thus, LTP can be shown to meet one of the principal criteria for a very long-term memory storage mechanism. However, under naturalistic environmental conditions, LTP may normally be retained in the hippocampus for only short periods of time.

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“…During wakefulness, acquired information is stored temporarily in the hippocampus, amygdala, and some cortical and subcortical areas; during subsequent sleep, these areas are reactivated to "consolidate" acquired information into more permanent storage in the neocortex (Hennevin and Hars, 1985;Buzsaki, 1989Buzsaki, , 1996Pavlides and Winson, 1989;Wilson and Mc-Naughton, 1994;Datta, 1999). These temporary storage areas would require a reactivating cue and/or triggering input during sleep (Bloch and Laroche, 1985;Bliss and Collingridge, 1993;Datta, 1999). The exact anatomical and physiological source of this cue and/or triggering input during natural sleep remains to be identified.…”

mentioning

confidence: 99%

Avoidance Task Training Potentiates Phasic Pontine-Wave Density in the Rat: A Mechanism for Sleep-Dependent Plasticity

2000

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Behavioral studies of learning and memory in both humans and animals support a role for sleep in the consolidation and integration of memories. The present study explored possible physiological mechanisms of sleep-dependent behavioral plasticity by examining the relationship between learning and state-dependent phasic signs of rapid eye movement (REM) sleep. Cortical electroencephalogram, electromyogram, eye movement, hippocampal theta-wave, and pontine-wave (P-wave) measures were recorded simultaneously in freely moving rats after a session of conditioned avoidance learning or a control session. After learning trials, rats spent 25.5% more time in REM sleep and 180.6% more time in a transitional state between slow-wave sleep and REM sleep (tS-R) compared with that in control trials. Both REM sleep and tS-R behavioral states are characterized by the presence of P-waves. P-wave density was significantly greater in the first four episodes of REM sleep after the learning session compared with the control session. Furthermore, the P-wave density change between the first and third REM sleep episodes was proportional to the improvement of task performance between the initial training session and the post-sleep retest session. These findings show that the increase in P-wave density during the post-training REM sleep episodes is correlated with the effective consolidation and retention of avoidance task learning.

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Enhancement of long‐term potentiation in the rat dentate gyrus by post‐trial stimulation of the reticular formation.

Cited by 27 publications

References 42 publications

Linear relationship between the maintenance of hippocampal long‐term potentiation and retention of an associative memory

Linear relationship between the maintenance of hippocampal long‐term potentiation and retention of an associative memory

Induction and Experience-Dependent Consolidation of Stable Long-Term Potentiation Lasting Months in the Hippocampus

Avoidance Task Training Potentiates Phasic Pontine-Wave Density in the Rat: A Mechanism for Sleep-Dependent Plasticity

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