1973
DOI: 10.1038/244351a0
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Enhancement of Metabolic Coronary Dilatation by Aspirin-like Substances by Suppression of Prostaglandin Feedback Control?

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Cited by 18 publications
(11 citation statements)
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“…It can be seen that there was an initial brief period of diminished CF which was quickly overcome by a marked diminution in coronary resistance, giving rise to increased CF whose magnitude depended on the length and frequency of stimulation (Figures 4 and 5). The initial decrease of CF is not affected by the administration of a-adrenoceptor blocking agents (Talesnik & Sunahara, 1973).…”
Section: Resultsmentioning
confidence: 95%
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“…It can be seen that there was an initial brief period of diminished CF which was quickly overcome by a marked diminution in coronary resistance, giving rise to increased CF whose magnitude depended on the length and frequency of stimulation (Figures 4 and 5). The initial decrease of CF is not affected by the administration of a-adrenoceptor blocking agents (Talesnik & Sunahara, 1973).…”
Section: Resultsmentioning
confidence: 95%
“…We also investigated the possibility that the endogenously synthesized prostaglandin could be a modulator of the adenylate cyclase activation, thus explaining the augmented MCD responses obtained in isolated perfused hearts by giving aspirin-like substances (Talesnik & Sunahara, 1973).…”
Section: Introductionmentioning
confidence: 99%
“…This slight diminution can be accounted for by the duration of the experiment. The unavoidable deterioration of the preparation, after 2 h of perfusion, has been shown to be a regular limitation of the Langen- dorff preparation (Aronson & Serlick, 1976 Influence of non-steroidal anti-inflammatory agents and arachidonic acid on coronary reactions to cardiostimulation or hypoxia Indomethacin (5 mg/l; 1.4 x 10-' M) or naproxen (25 mg/l; 1 x 10' M) were administered by slow infusion or at constant concentration in a series of experiments in which we tested the coronary reactions as previously described for indomethacin and aspirin (Talesnik & Sunahara, 1973). The immediate reaction of the coronaries was a transient but slight vasodilatation that subsided in about 5 to 10 min.…”
Section: Resultsmentioning
confidence: 99%
“…It must also be considered that exogenously administered AA may be metabolized to prostaglandins somewhat differently from endogenously released arachidonate although AA could easily be incorporated into the phospholipids of the intact heart (Isakson et al, 1977a). Thus, the explanation originally given by us for the enhancement (Talesnik & Sunahara, 1973) is incomplete in as much as inhibition of the prostaglandin-synthetase located in the myocardial cell is concerned.…”
Section: Effect Of Non-steroidal Anti-inflammatory Agents On the Reacmentioning
confidence: 99%
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