Enhancement of MR angiography with iron oxide: preliminary studies in whole-blood phantom and in animals.

Frank, Howard A.; Weissleder, Ralph; Brady, T J

doi:10.2214/ajr.162.1.8273667

Cited by 86 publications

(43 citation statements)

References 8 publications

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“…For example, T 1 effects were suppressed by strong T 2 effects at MION dosages equivalent to 6 or 10 mg/kg iron. These results are in accordance with recent studies [50,67]. In conclusion, the sensitivity of T 1 -weighted MRI to determine MION- Krause/Kwong/Xiong/Gragoudas/Young induced changes of rSI is limited.…”

Section: Discussionsupporting

confidence: 92%

“…These findings were in agreement with T 1 -and T 2 -weighted SI obtained with 3D-SPGR sequences [33,53,54,57]. The SI had been shown in vitro and in vivo to correlate with the concentration of MION [50] and the blood volume [33,38,53,54,57]. In the present study, increases in T 1 -and decreases in T 2 -weighted rSI were also measured at 24 h. Histology did not reveal iron staining of the intracellular or interstitial space within 0.5 h, but predominantly cytoplasmic iron staining at 24 h after the injection ( fig.…”

Section: Discussionsupporting

confidence: 88%

“…The molecular weight is 11 kD. The plasma half-life is about 3.0-4.5 h in rats [40,50] and 4.0 h in rabbits [51]. The long plasma half-life and strong paramagnetic effects render MION useful for blood volume measurements.…”

Section: Contrast Agentmentioning

confidence: 99%

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MRI of Blood Volume and Cellular Uptake of Superparamagnetic Iron in an Animal Model of Choroidal Melanoma

Krause

Kwong²,

Xiong³

et al. 2002

Ophthalmic Res

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Functional magnetic resonance imaging (MRI), using monocrystalline iron oxide nanoparticles (MION) as a new intravascular contrast agent, was adapted for a rabbit model of pigmented choroidal melanoma. Three-dimensionally spoiled gradient recalled sequences were used for the quantitative assessment of blood volume and cellular uptake. In all ocular tissues studied, MION reduced the T₂-weighted signal intensity within 0.5 h and at 24 h (both p < 0.05) after the injection. In individual tumors, MION reduced the T₂-weighted signal intensity by 46–78% within 0.5 h and by 24–48% at 24 h. In addition, MION increased the T₁-weighted signal intensity in all tissues. T₂ yielded a higher sensitivity than T₁-weighted images. Functional MRI with MION is a noninvasive technique with regard to the eye, permitting measurement of blood volume and cellular uptake of the contrast agent. Further study is necessary to determine the feasibility of this technique for the tumor diagnosis and evaluation of tumor viability following treatments.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 88%

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MRI of Blood Volume and Cellular Uptake of Superparamagnetic Iron in an Animal Model of Choroidal Melanoma

Krause

Kwong²,

Xiong³

et al. 2002

Ophthalmic Res

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“…This nanoparticle was a cross-linked phospholipid nanoemulsion loaded with oleate-coated magnetite particles. The nanoemulsion reduced T2 relaxation effects, which significant improved positive T1w contrast detection at the nanomolar level 97 . Fumagillin was also loaded into the emulsions containing CIONs 98 ( Fig.…”

Section: Cardiovascular Diseasesmentioning

confidence: 99%

Polymeric multifunctional nanomaterials for theranostics

et al. 2015

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Nanocarriers provide a platform to integrate therapy and diagnostics, which is an emerging direction in medical practice. Beyond simply therapeutic functionality, theranostic nanomaterials have been designed to deliver multiple components and imaging agents, facilitating simultaneous and synergistic diagnosis and therapies. In this article, polymeric materials with diverse functionalities and properties for manufacturing theranostic nanomaterials are discussed and compared. We focused on recent advancements in polymeric multifunctional nanomaterials for synergistic theranostics. The drugs and imaging agents were encapsulated within and/or conjugated to the surface of the nanocarriers, according to the fabrication process and carrier type. In parallel with therapy, polymeric multifunctional nanomaterials can be exploited to exhibit distinctive magnetic, electrical, and optical properties for concomitant imaging. This has been accomplished by incorporating various imaging agents, such as fluorescent dyes, biomarkers, quantum dots, metal composites, and magnetic nanoparticles. We discussed theranostic nanomaterial synthesis, carrier fabrication and its applications. By presenting this comprehensive review of the state-of-the-art, we demonstrated that polymeric multifunctional nanomaterials exhibit distinctive advantages and features in theranostics. DisciplinesBiomechanics and Biotransport | Nanoscience and Nanotechnology | Polymer This is an Accepted Manuscript, which has been through the Royal Society of Chemistry peer review process and has been accepted for publication.Accepted Manuscripts are published online shortly after acceptance, before technical editing, formatting and proof reading. Using this free service, authors can make their results available to the community, in citable form, before we publish the edited article. We will replace this Accepted Manuscript with the edited and formatted Advance Article as soon as it is available.You can find more information about Accepted Manuscripts in the Information for Authors.

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“…In addition, they reduce the T1 -relaxation time of blood and therefore increase blood pool signal intensity on T1-weighted scans (1 11. Iron oxides have been shown to improvc the quality of MR angiograms (M-1 by a T1-effect (12). Both effects should enhance hepatic vascular contrast, rendering iron oxides an ideal candidate for MF!…”

mentioning

confidence: 99%

Evaluation of portal MR angiography using superparamagnetic iron oxide

Knollmann

Böck

Teltenkötter

et al. 1997

Magnetic Resonance Imaging

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The purpose of our research was to determine the effects of superparamagnetic iron oxide on MR imaging of the portal venous system. Eight piglets were examined in deep anaesthesia and respiratory arrest using a time-of-flight magnetic resonance fast low angle shot, two-dimensional angiography sequence at 1.5T, MR angiograms were acquired precontrast and after intravenous administration of a cumulative dose of 10, 20 and 40 mumol/kg SHU 555A, a superparamagnetic iron oxide contrast agent for MR imaging with a particle size of 60 nm. For each dose, two subsequent sets of scans were obtained and reconstructed by a maximum-intensity-projection algorithm. Hepatic parenchymal and portal venous signal intensities were measured, and portal vein contrast calculated for each set of scans. All examinations were visually rated as to portal vein contrast and homogeneity by two blinded observers. Receiver operating characteristics of both observers were analyzed. The contrast agent reduced hepatic parenchymal signal in a dose-dependent way. After a cumulative dose of 10 mumol iron oxide, hepatic parenchymal signal intensity decreased to 63 +/- 6% (average of measurements at 4 and 14 minutes, mean +/- standard error of the mean), after 20 mumol to 24 +/- 3%, and after 40 mumol to 12 +/- 1% of control. Intravascular signal in the left main portal vein branch increased to 117 +/- 6%, 127 +/- 10%, and 133 +/- 9% of control, respectively. The contrast-to-noise ratio of the portal vein improved (521 +/- 90%, 891 +/- 178%, and 995 +/- 201% of control in the left portal vein main branch). Intravascular signal intensities increased slightly. The combined effect improved contrast of the portal vein stem and its branches. Receiver operating characteristics analysis documented dose-dependency of contrast medium effects on portal venous contrast and intravascular homogeneity. Visual rating also indicated a positive effect on portal venous contrast. The superparamagnetic iron oxide agent improved portal venous contrast with surrounding hepatic parenchyma in this normal animal model, and could potentially result in more accurate diagnosis of portal venous pathology.

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Enhancement of MR angiography with iron oxide: preliminary studies in whole-blood phantom and in animals.

Abstract: OBJECTIVE.We hypothesized that the previously observed Ti effect of a small

Cited by 86 publications

References 8 publications

MRI of Blood Volume and Cellular Uptake of Superparamagnetic Iron in an Animal Model of Choroidal Melanoma

MRI of Blood Volume and Cellular Uptake of Superparamagnetic Iron in an Animal Model of Choroidal Melanoma

Polymeric multifunctional nanomaterials for theranostics

Evaluation of portal MR angiography using superparamagnetic iron oxide

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