Enhancement of MSC adhesion and therapeutic efficiency in ischemic heart using lentivirus delivery with periostin

Cho, Yun-Hyeong; Cha, Min‐Ji; Song, Byeong‐Wook; Kim, Il-Kwon; Song, Heesang; Chang, Won Hyuk; Lim, Soyeon; Ham, Ok Kyung; Lee, Seyeon; Choi, Eunmi; Kwon, Hyuck Moon; Hwang, Ki‐Chul

doi:10.1016/j.biomaterials.2011.10.078

Cited by 48 publications

(38 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…61,62 It has been overexpressed in MSCs to increase the survival of these cells. 59 In periostin-overexpressing MSCs, the PI3K/Akt pathway was activated, and the therapeutic efficiency was increased. Periostin-overexpressing MSCs and the conditioned medium from these cells were able to increase the survival of cardiomyocytes under hypoxic conditions in a coculture system.…”

Section: The Pi3k/akt Pathway and Survival Ability Of Mscsmentioning

confidence: 99%

“…In cellular therapy studies, stimulators of the pathway and the overexpression of some major components of the pathway have been used to induce the repair of infarcted cardiovascular cells and were demonstrated to increase the efficacy of MSCs. 22,58,59 In tissue engineering studies, MSCs have been transplanted together with various growth factors, such as VEGF and fibroblast growth factor (FGF), to increase the functionality of MSCs.…”

Section: The Pi3k/akt Pathway In Mscsmentioning

confidence: 99%

See 1 more Smart Citation

The Key Regulatory Roles of the PI3K/Akt Signaling Pathway in the Functionalities of Mesenchymal Stem Cells and Applications in Tissue Regeneration

Chen

Crawford

Chen

et al. 2013

Tissue Engineering Part B: Reviews

205

161

View full text Add to dashboard Cite

Mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into various cell types and have been widely used in tissue engineering application. In tissue engineering, a scaffold, MSCs and growth factors are used as essential components and their interactions have been regarded to be important for regeneration of tissues. A critical problem for MSCs in tissue engineering is their low survival ability and functionality. Most MSCs are going to be apoptotic after transplantation. Therefore, increasing MSC survival ability and functionalities is the key for potential applications of MSCs. Several approaches have been studied to increase MSC tissue forming capacity including application of growth factors, overexpression of stem cell regulatory genes, and improvement of biomaterials for scaffolds. The effects of these approaches on MSCs have been associated with activation of the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway. The pathway plays central regulatory roles in MSC survival, proliferation, migration, angiogenesis, cytokine production, and differentiation. In this review, we summarize and discuss the literatures related to the roles of the PI3K/Akt pathway in the functionalities of MSCs and the involvement of the pathway in biomaterials-increased MSC functionalities. Biomaterials have been modified in their properties and surface structure and loaded with growth factors to increase MSC functionalities. Several studies demonstrated that the biomaterials-increased MSC functionalities are mediated by the activation of the PI3K/Akt pathway. MSCs are going to be apoptotic after transplantation. Therefore, increasing MSC survival ability and functionalities is the key for potential applications of MSCs. Several approaches have been studied to increase MSC tissue forming capacity including application of growth factors, overexpression of stem cell regulatory genes, and improvement of biomaterials for scaffolds. The effects of these approaches on MSCs have been associated with activation of the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway. The pathway plays central regulatory roles in MSC survival, proliferation, migration, angiogenesis, cytokine production, and differentiation. In this review, we summarize and discuss the literatures related to the roles of the PI3K/Akt pathway in the functionalities of MSCs and the involvement of the pathway in biomaterials-increased MSC functionalities. Biomaterials have been modified in their properties and surface structure and loaded with growth factors to increase MSC functionalities. Several studies demonstrated that the biomaterials-increased MSC functionalities are mediated by the activation of the PI3K/Akt pathway.

show abstract

Section: The Pi3k/akt Pathway and Survival Ability Of Mscsmentioning

confidence: 99%

Section: The Pi3k/akt Pathway In Mscsmentioning

confidence: 99%

The Key Regulatory Roles of the PI3K/Akt Signaling Pathway in the Functionalities of Mesenchymal Stem Cells and Applications in Tissue Regeneration

Chen

Crawford

Chen

et al. 2013

Tissue Engineering Part B: Reviews

205

161

View full text Add to dashboard Cite

show abstract

“…Cho et al transferred periostin-overexpressing mesenchymal cells, resulting the improved cardiac function [39].…”

Section: Trial For Diagnostic or Clinical Applicationmentioning

confidence: 99%

Periostin in dental science

Takayama

Kudo

2012

Japanese Dental Science Review

View full text Add to dashboard Cite

“…Furthermore, the authors found that levels of activated AKT and ERK were increased, implicating these pathways as major mediators of the antiapoptotic effects of periostin. 68 In addition to overexpression and inhibition of components of the P13K/Akt pathway, other strategies to improve MSC survival have focused on their response to hypoxic conditions. Hypoxia leads to the generation of reactive oxygen species (ROS) that mediate oxidative stress and induce apoptosis in MSCs.…”

Section: Survivalmentioning

confidence: 99%

Insights Into Signaling in Cell-Based Therapy for Heart Disease

Rieger

Tompkins

Banerjee

et al. 2017

Signal Transduction Insights

View full text Add to dashboard Cite

Over the past several decades, stem cell therapy for heart disease has been translated from the bench to the bedside and in clinical trials improves cardiac structure and function in both ischemic and nonischemic cardiac disease. Although the regenerative effects of stem cells in cardiac disease are mediated by both paracrine and cell-to-cell contact mechanisms, many of the downstream signaling pathways remain to be fully elucidated. This review outlines what is currently known about the main signaling pathways involved in mesenchymal stem cell and cardiac stem cell survival, proliferation, and migration and mechanisms of action to repair the damaged heart.

show abstract

Enhancement of MSC adhesion and therapeutic efficiency in ischemic heart using lentivirus delivery with periostin

Cited by 48 publications

References 36 publications

The Key Regulatory Roles of the PI3K/Akt Signaling Pathway in the Functionalities of Mesenchymal Stem Cells and Applications in Tissue Regeneration

The Key Regulatory Roles of the PI3K/Akt Signaling Pathway in the Functionalities of Mesenchymal Stem Cells and Applications in Tissue Regeneration

Periostin in dental science

Insights Into Signaling in Cell-Based Therapy for Heart Disease

Contact Info

Product

Resources

About