Flexible and air-stable phototransistors are highly demanded for wearable nearinfrared (NIR) image sensors. However, advanced NIR sensors via low-cost, solution-based processes remained a challenge. Herein, high-performance inorganic-organic hybrid phototransistors are achieved based on solution processed n-type metal oxide/polymer semiconductor heterostructures of In 2 O 3 /poly{5,5′-bis[3,5-bis(thienyl)phenyl]-2,2′-bithiophene-3ethylesterthiophene]} (PTPBT-ET). The In 2 O 3 /PTPBT-ET hybrid phototransistor combines the advantages of both fast electron transport in In 2 O 3 and high photoresponse in PTPBT-ET, showing high saturation mobility of 7.1 cm 2 V −1 s −1 and large current on/off ratio of >10 7 . As a result, the phototransistor exhibits high performance towards NIR light sensing with a responsivity of 200 A W −1 , a specific detectivity of 1.2 × 10 13 Jones, and fast photoresponse with rise/ fall time of 5/120 ms. Remarkably, the hybrid phototransistor, without any passivation, demonstrates excellent electrical stability without performance degradation even after 160 days in air. A 10 × 10 phototransistor array is also enabled by virtue of the high device uniformity. Lastly, flexible In 2 O 3 /PTPBT-ET phototransistor on polyimide substrate is attained, exhibiting outstanding mechanical flexibility up to 1000 bending/releasing cycles at a bending radius of 5 mm. These achievements pave the way for constructing air-stable hybrid phototransistors for flexible NIR image sensor applications.