Enhancement of nerve healing with the combined use of amniotic membrane and granulocyte-colony-stimulating factor

Fesli, Atilla; Sarı, Alper; Yılmaz, Nejat; Çömelekoğlu, Ülkü; Taşdelen, Bahar

doi:10.1016/j.bjps.2014.02.011

Cited by 20 publications

(15 citation statements)

References 28 publications

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“…As reported by Fesli et al . 41 , the functional recovery after a nerve injury is referred not only to the regenerating axons number but also to a correct guidance towards their appropriate targets.…”

Section: Discussionmentioning

confidence: 99%

New bioresorbable wraps based on oxidized polyvinyl alcohol and leukocyte-fibrin-platelet membrane to support peripheral nerve neurorrhaphy: preclinical comparison versus NeuraWrap

Stocco

Barbon

Macchi

et al. 2019

Sci Rep

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Nerve wrapping improves neurorrhaphy outcomes in case of peripheral nerve injuries (PNIs). The aim of this preclinical study was to assess the efficacy of two novel biodegradable wraps made of a synthetic 1% oxidized polyvinyl alcohol (OxPVA) and a natural leukocyte-fibrin-platelet membrane (LFPm) versus the commercial product NeuraWrap. After rats sciatic nerve transection and neurorrhaphy, the wraps were implanted and compared for functional outcome, by sciatic function index assessment; structural characteristics, by histological/immunohistochemical analysis; ultrastructural features, by transmission electron microscopy. Moreover, a morphometric study was also performed and collagen distribution was observed by Second Harmonic Generation microscopy. After 12 weeks from implantation, all wraps assured nerve function recovery; no scar tissue/neuromas were visible at dissection. LFPm wraps were completely resorbed, while residues of OxPVA and NeuraWrap were observed. In all groups, biocompatibility was confirmed by the absence of significant inflammatory infiltrate. According to histological/immunohistochemical analysis and morphometric findings, OxPVA and LFPm wraps were both effective in preserving nerve integrity. These results assess that bioengineered OxPVA and LFPm wraps successfully guarantee favorable lesion recovery after PNI/neurorrhaphy and, in future, may be considered an interesting alternative to the commercial NeuraWrap.

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Section: Discussionmentioning

confidence: 99%

New bioresorbable wraps based on oxidized polyvinyl alcohol and leukocyte-fibrin-platelet membrane to support peripheral nerve neurorrhaphy: preclinical comparison versus NeuraWrap

Stocco

Barbon

Macchi

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“…From the PubMed search and after the inclusion and exclusion criteria were applied, 15 articles on animal models were analyzed and relevant data were extracted [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] (Table 2). Among these 15 studies, 10 were published after 2009, evidence of the recent interest in using amniotic membrane for nerve repair.…”

Section: Preclinical Proof Of Conceptmentioning

confidence: 99%

Can the amniotic membrane be used to treat peripheral nerve defects? A review of literature

Bourgeois

Loisel

Obert

et al. 2019

Hand Surgery and Rehabilitation

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“…Combining G-CSF with other agents has also been pursued, for example, hematopoietic growth factors (erythropoietin) (21), pharmacotherapies (e.g., simvastatin) (37), amniotic membrane wrappings (31), and others in experimental models of stroke, SCI, and AMI. A majority of these studies reported enhanced effects of combination therapy, or synergism, when compared with treatment with either drug alone.…”

Section: G-csf As Stand-alone and Adjunctive Therapy: Implications Fomentioning

confidence: 99%

G-CSF as an Adjunctive Therapy with Umbilical Cord Blood Cell Transplantation for Traumatic Brain Injury

et al. 2015

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Traumatic brain injury (TBI), a major contributor to deaths and permanent disability worldwide, has been recently described as a progressive cell death process rather than an acute event. TBI pathophysiology is complicated and can be distinguished by the initial primary injury and the subsequent secondary injury that ensues days after the trauma. Therapeutic opportunities for TBI remain very limited with patients subjected to surgery or rehabilitation therapy. The efficacy of stem cell-based interventions, as well as neuroprotective agents in other neurological disorders of which pathologies overlap with TBI, indicates their potential as alternative TBI treatments. Furthermore, their therapeutic limitations may be augmented when combination therapy is pursued instead of using a single agent. Indeed, we demonstrated remarkable combined efficacy of human umbilical cord blood (hUCB) cell therapy and granulocyte-colony-stimulating factor (G-CSF) treatment in TBI models, providing essential evidence for the translation of this approach to treat TBI. Further studies are warranted to determine the mechanisms underlying therapeutic benefits exerted by hUCB + G-CSF in order to enhance its safety and efficacy in the clinic.

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Enhancement of nerve healing with the combined use of amniotic membrane and granulocyte-colony-stimulating factor

Cited by 20 publications

References 28 publications

New bioresorbable wraps based on oxidized polyvinyl alcohol and leukocyte-fibrin-platelet membrane to support peripheral nerve neurorrhaphy: preclinical comparison versus NeuraWrap

New bioresorbable wraps based on oxidized polyvinyl alcohol and leukocyte-fibrin-platelet membrane to support peripheral nerve neurorrhaphy: preclinical comparison versus NeuraWrap

Can the amniotic membrane be used to treat peripheral nerve defects? A review of literature

G-CSF as an Adjunctive Therapy with Umbilical Cord Blood Cell Transplantation for Traumatic Brain Injury

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