Enhancement of nigral graft survival in rat brain with the systemic administration of synthetic fibronectin peptide V

Duan, Wei; Zhao, Li-Ru; Westerman, Marcus A.; Lovick, Darren; Furcht, Leo T.; McCarthy, James B.; Low, Walter C.

doi:10.1016/s0306-4522(00)00299-2

Cited by 20 publications

(9 citation statements)

References 31 publications

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“…Glial activation can be detrimental to neural cell survival in a number of transplantation paradigms, including animal models of spinal cord injury (Beattie 2004), Parkinson's Disease (Duan et al, 2000; Sortwell et al, 2001), and Huntington's disease (Mazurova et al, 2006; Johann et al, 2007). The activation of inflammatory processes in transplanted neural tissue is thought to stem, in part, from the introduction of foreign cells into a damaged, diseased, or dysfunctional environment, and is also thought to be aggravated by the surgical procedure itself (Bastian et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…Treatments that reduce inflammation such as the anti-inflammatory drug minocycline (Zhang et al, 2003; Johann et al, 2007) and synthetic fibronectin peptide V (Duan et al, 2000) are effective in improving neural transplant survival. Recent studies have identified a number of nutritional compounds with the ability to influence inflammation in vitro and in vivo (e.g.…”

Section: Introductionmentioning

confidence: 99%

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Blueberry supplementation attenuates microglial activation in hippocampal intraocular grafts to aged hosts

Willis

Freeman

Bickford

et al. 2009

Glia

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Transplantation of central nervous tissue has been proposed as a therapeutic intervention for agerelated neurodegenerative diseases and stroke. However, survival of embryonic neuronal cells is hampered by detrimental factors in the aged host brain such as circulating inflammatory cytokines and oxidative stress. We have previously found that supplementation with 2% blueberry in the diet increases graft growth and neuronal survival in intraocular hippocampal grafts to aged hosts. In the present study we explored possible biochemical mechanisms for this increased survival, and we here report decreased microglial activation and astrogliosis in intraocular hippocampal grafts to middle-aged hosts fed a 2% blueberry diet. Markers for astrocytes and for activated microglial cells were both decreased long-term after grafting to blueberry-treated hosts compared to agematched rats on a control diet. Similar findings were obtained in the host brain, with a reduction in OX-6 immunoreactive microglial cells in the hippocampus of those recipients treated with blueberry. In addition, immunoreactivity for the pro-inflammatory cytokine IL-6 was found to be significantly attenuated in intraocular grafts by the 2% blueberry diet. These studies demonstrate direct effects of blueberry upon microglial activation both during isolated conditions and in the aged host brain and suggest that this nutraceutical can attenuate age-induced inflammation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Blueberry supplementation attenuates microglial activation in hippocampal intraocular grafts to aged hosts

Willis

Freeman

Bickford

et al. 2009

Glia

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“…Composed of a heterogeneous lattice of proteoglycans and glycoproteins, ECM provides structural support and anchorage for cells and regulates cell adhesion, migration and proliferation [44]. Among all the ECM molecules, laminin and fibronectin, together with their peptide motifs, have been recognized to facilitate nerve development and offer a neuroprotective function in the nervous system after injury [45][46][47]. Thus, laminin, fibronectin, collagen and their peptide motifs have been used to modify scaffolds, so as to improve cell adhesion and axon sprouting, and enhance neural regeneration.…”

Section: Modification Of Engineered Extracellular Matrix Componentsmentioning

confidence: 99%

Hyaluronic acid-based scaffold for central neural tissue engineering

Wang

et al. 2012

Interface Focus.

129

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Central nervous system (CNS) regeneration with central neuronal connections and restoration of synaptic connections has been a long-standing worldwide problem and, to date, no effective clinical therapies are widely accepted for CNS injuries. The limited regenerative capacity of the CNS results from the growth-inhibitory environment that impedes the regrowth of axons. Central neural tissue engineering has attracted extensive attention from multi-disciplinary scientists in recent years, and many studies have been carried out to develop cell-and regenerationactivating biomaterial scaffolds that create an artificial micro-environment suitable for axonal regeneration. Among all the biomaterials, hyaluronic acid (HA) is a promising candidate for central neural tissue engineering because of its unique physico-chemical and biological properties. This review attempts to outline current biomaterials-based strategies for CNS regeneration from a tissue engineering point of view and discusses the main progresses in research of HA-based scaffolds for central neural tissue engineering in detail.

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“…39 The administration of synthetic fibronectin peptide V can increase the survival of neural grafts in mesencephal substantia nigra in vivo and ameliorate the motion behavior of PD animals, suggesting the antiapoptotic effect of fibronectin. 40 In the microglia, fibronectin can activate the PI3K-Akt and mitogen-activated protein kinase kinase-extracellular signalregulated kinase-signaling pathways, enhance the expression levels of neurotrophic factors, 41 and alleviate the release of proinflammatory factor interleukin 1, all of which contribute to neural repair and neuronal survival. 42,43 In the fibronectin knockout mice, the volume of traumatic brain injury is significantly increased and more apoptotic cell death is observed, but with intravenous injection of fibronectin before the injury, the restoration of neural deficits can be seen in the fibronectin-deficient mice, indicating that fibronectin may play neuroprotective role in the repair of brain traumatic injury and may be a novel molecular target for therapeutic interventions.…”

Section: Neuroprotective Effect Of Fibronectin and Its Molecular Mechmentioning

confidence: 99%

New insights into the altered fibronectin matrix and extrasynaptic transmission in the aging brain

Wang

Yin

Chen

2011

Journal of Clinical Gerontology and Geriatrics

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a b s t r a c tThe extracellular matrix (ECM) is a fibrillar meshwork consisting of many long-chain polyelectrolytes, such as glycoproteins (e.g., fibronectin), glycosaminoglycans, and proteoglycans, all of which fabricate an anisotropic microenvironment that bears dynamic and preferential intercellular communication channels, that is, extrasynaptic transmission. Fibronectin is a ubiquitous ECM component, which accumulates to form poriferous perineuronal nets to regulate matrix organization, such as specific binding to growth factor receptors or clearance of degraded products, and directing cell behaviors, including receptor activation that transduces signals into cells, in addition to its supportive and adhesional roles. Integrins are a family of transmembrane glycoprotein receptors for both ECM proteins like fibronectin and neural growth factors like insulin-like growth factor-1, and the binding of fibronectin to integrins transactivates the intracellular signaling events, such as phosphatidylinositol 3-kinase/protein kinase B pathway to regulate or amplify growth factor-like neuroprotective actions. In the aging brain, the fibronectin, integrins, and other ECM proteins are all downregulated, which brings about the altered structural and functional properties (e.g., neurotransmitter storage, clearance of metabolites, and diffusion parameters) of ECM and extrasynaptic transmission and underlies the molecular mechanism of neurodegenerative disorders. In this article, the neurotrophic mechanism of fibronectin and integrins for pathogenesis of Parkinson's disease and Alzheimer's disease is analyzed, involving interaction of integrin and insulin-like growth factor-1 receptor or glial cell line-derived neurotrophic factor receptor, and the potential therapeutic and diagnostic implications of fibronectin are also discussed.

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Enhancement of nigral graft survival in rat brain with the systemic administration of synthetic fibronectin peptide V

Cited by 20 publications

References 31 publications

Blueberry supplementation attenuates microglial activation in hippocampal intraocular grafts to aged hosts

Blueberry supplementation attenuates microglial activation in hippocampal intraocular grafts to aged hosts

Hyaluronic acid-based scaffold for central neural tissue engineering

New insights into the altered fibronectin matrix and extrasynaptic transmission in the aging brain

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