Enhancement of Periodontal Tissue Regeneration by Transplantation of Bone Marrow Mesenchymal Stem Cells

Abstract

These findings suggest that auto-transplantation of bone marrow mesenchymal stem cells is a novel option for periodontal tissue regeneration.

Periodontal regeneration using ex vivo autologous stem cells engineered to express the BMP-2 gene: an alternative to alveolaplasty

“…MSCs may have been the primary contributing factor as they offered a source of cells that were ready to regenerate. 14,41,42 There is dynamic secretion of transduced BMP-2 protein in vivo and the concentration of local BMP-2 may be affected by the niche. The ex vivo culture may be controlled by the total fluid amount, CO 2 and O 2 conditions without any other protein interference.…”

“…12,13 Periodontal regeneration therapy with transplanted MSCs has been shown to increase the regeneration of the cementum, periodontal ligaments and alveolar bone. 14 In a previous study, MSCs were induced into an osteogenic phenotype, such that they were able to repair alveolar bone defects (5-mm high) without investigating the periodontal attachment apparatus. 15 Previously, we reported that replication-defective adenoviral BMP-2 gene transfer to MSCs increased bone formation in critical-sized craniofacial bony defects.…”

The Scope of Stem Cells in Periodontal Regeneration

“…They have been incorporated in class III furcation defects in canine models resulting in successful results [47]. BMMSCs were present in the defect even after 1 month, suggesting that they ultimately form various periodontal cells needed for regeneration [47].…”

Role of stem cells in tooth bioengineering

“…Thus, the bone marrow provides an alternative source of MSC for the treatment of periodontal diseases. 15 Bone marrow-derived MSC share numerous characteristics with dental pulp stem cells (DPSC) and are both able to form bone-like or tooth-like structures. However, BMSC display a lower odontogenic potential than DPSC, indicating that MSCs from different embryonic origins are not equivalent.…”