Enhancement of Peritoneal Macrophages Reduces Postoperative Peritoneal Adhesion Formation

Ar'Rajab, A; Dawidson, Ingemar; Sentementes, J. T.; Sikes, Pat; Harris, Richard B.; Mileski, William J.

doi:10.1006/jsre.1995.1048

Cited by 48 publications

(42 citation statements)

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“…In a previous study from our labora-and migration as have been described in other organs including the peritoneum [25] and the lung [26]. tory, we have shown that enhancement of peritoneal macrophages markedly decreases postoperative adheAn explanation for the increase in adhesion formation following inhibition of CD18 may relate to collagen sion formation [17]. The present results indicate that PMNs may play a role in the development of postopera-degradation.…”

Section: Statisticssupporting

confidence: 57%

“…No changes were seen in the number of procedures were described in details previously [17]. Briefly, the ab-peritoneal macrophages (3.4 1 10 7 { 0.8 1 10 7 in condomen was opened through a midline incision using sterile technique trols vs 3.5 1 10 7 { 0.4 1 10 7 in anti-CD18 antibodyand closed at the end of surgery in two layers with a continuous treated animals).…”

Section: Statisticsmentioning

confidence: 99%

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The Role of Neutrophils in Peritoneal Adhesion Formation

Ar'Rajab

Mileski

Sentementes

et al. 1996

Journal of Surgical Research

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Section: Statisticssupporting

confidence: 57%

Section: Statisticsmentioning

confidence: 99%

The Role of Neutrophils in Peritoneal Adhesion Formation

Ar'Rajab

Mileski

Sentementes

et al. 1996

Journal of Surgical Research

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“…During the postoperative period, monocytes migrate from circulating blood to the wounded areas, transform into macrophages, and secrete cytokines to recruit fibroblasts that produce fibrous tissue ‘bridges’ between tissue surfaces [4]. An overabundance of activated macrophages inside the abdominal cavity after surgery could increase the occurrence of adhesions [5,6]. Additionally, these macrophages and other polymorphonuclear leukocyte cells may also migrate into the initial fibrin connections between damaged tissues, further preventing fibrinolysis from occurring [7].…”

Section: Introductionmentioning

confidence: 99%

Cross-Linked Hyaluronic Acid Films to Reduce Intra-Abdominal Postsurgical Adhesions in an Experimental Model

Falabella

Chen²

2009

Dig Surg

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Background/Aims: Intra-abdominal adhesions typically occur after surgically damaged tissues are situated in apposition, leading to fibrotic connections. The goal of this study was to demonstrate the in vivo efficacy of a cross-linked and insoluble hyaluronic acid (HA) film to reduce postsurgical adhesion in a rat model. Methods: To measure in vitro adhesion resistance, porcine monocytes were deposited on the surface of films and their attachment was monitored by scanning electron microscopy. A rat cecum abrasion and abdominal insult model was utilized to demonstrate in vivo efficacy. Briefly, an HA film was deployed as a barrier between the damaged cecal and abdominal tissue surfaces for 21 days; control animals did not receive treatment. At the study conclusion, the rats were sacrificed and the degree of adhesion was determined using a scale from 0 to 3, where 0 = no adhesion and 3 = severe fibrosis. Results: HA films resisted monocyte adhesion in vitro. The in vivo study results demonstrated a significantly lower mean adhesion score (0.625 ± 0.517) with HA film treatment compared to the controls (2.09 ± 1.22). Conclusion: Placement of HA films between injured tissues significantly decreases the severity of abdominal adhesions. Furthermore, the HA film’s resistance to monocyte adhesion could be contributory to lowering in vivo adhesion scores.

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“…Intra-abdominal adhesions can lead to severe complications during and after surgeries (1). This has led to the search for a method to prevent intra-abdominal adhesions (2)(3)(4)(5)(6)(7)(8)(9)(10). In physiological conditions, fibrin exudates accelerate the healing process in damaged tissues.…”

Section: Introductionmentioning

confidence: 99%

“…In physiological conditions, fibrin exudates accelerate the healing process in damaged tissues. However, in pathological conditions, this fibrin tissue might lead to the formation of unwanted fibrous bands (6). Inflammatory reactions that can result following surgery or bacterial infections can lead to the formation of fibrin deposits in the intra-peritoneal cavity, which in turn leads to the formation of intraabdominal adhesions (7).…”

Section: Introductionmentioning

confidence: 99%

Comparing Lavage of the Peritoneal Cavity with Lidocaine, Bupivacaine and Normal Saline to Reduce the Formation of Abdominal Adhesion Bands in Rats

Parsa

Saravani

Sameei-Rad

et al. 2017

MJMS

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Background: Intra-abdominal adhesions are fibrous bands that develop after abdominal surgery or inflammation and cause mortality and morbidity following surgeries. This study aimed to assess the effects of bupivacaine, saline and two doses of lidocaine, after peritoneal lavage and to compare their effects in reducing abdominal adhesions in rat.Methods: In a blinded, randomised, placebo-controlled clinical trial, 50 female rats were anaesthetised and the parietal peritoneum was scratched to induce punctate bleeding. The rats were randomly assigned to five groups: saline, lidocaine 2% (3 and 6 mg/kg), bupivacaine 0.25% (2 mg/kg) and control (no irrigation). The peritoneal cavity was irrigated with the appropriate solution during laparotomy. Two weeks later, re-laparotomy was performed. The quantity, quality, severity and scores of adhesions were recorded and compared.Results: The quantity and quality of adhesions were significantly higher in the control group than in the lidocaine (6 mg/kg) and bupivacaine groups. The quality of the adhesions was higher in the normal saline group than in the lidocaine (6 mg/kg) and bupivacaine groups. The severity of adhesions between the lidocaine 3 and 6 mg/kg groups and between the lidocaine 3 mg/ kg and saline groups was lower than that in the control group.Conclusion: Using lidocaine (6 mg/kg) and bupivacaine lavage in first laparotomy reduces abdominal peritoneal obstruction because of the formation of adhesion bands.

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Enhancement of Peritoneal Macrophages Reduces Postoperative Peritoneal Adhesion Formation

Cited by 48 publications

References 0 publications

The Role of Neutrophils in Peritoneal Adhesion Formation

The Role of Neutrophils in Peritoneal Adhesion Formation

Cross-Linked Hyaluronic Acid Films to Reduce Intra-Abdominal Postsurgical Adhesions in an Experimental Model

Comparing Lavage of the Peritoneal Cavity with Lidocaine, Bupivacaine and Normal Saline to Reduce the Formation of Abdominal Adhesion Bands in Rats

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