Enhancement of pheromone response by RGS9 and Gβ5 in yeast

Ajit, Seena K.; Young, Kimberly A.

doi:10.1016/j.bbrc.2004.09.100

Cited by 6 publications

(2 citation statements)

References 38 publications

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“…Because of the structural properties shared by both dimers, one might expect that the RGS/ Gβ5 complex would share a similar function. Indeed, Ajit et al have shown that RGS9/Gβ5 positively regulates pheromone responses when heterologously expressed in yeast [100]. However, several groups have reported the inability of the RGS/Gβ5 complex to either activate adenylyl cyclase or PLCβ, or bind GDP-Gα subunit in mammalian systems [93,101].…”

Section: C/r7 Subfamilymentioning

confidence: 99%

Regulatory mechanisms involved in modulating RGS function

Jean-Baptiste

Yang

Greenwood

2006

Cell. Mol. Life Sci.

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Regulator of G-Protein Signaling (RGS) refers to a conserved 120-125 amino acid motif that was first identified by its ability to negatively regulate G-Protein-Coupled Receptor (GPCR) signalling. Mechanistically, RGSs were found to regulate GPCR responses by binding to and stimulating the GTPase activity of the receptor-activated GTP-bound G alpha subunits. There are now over 25 mammalian RGSs containing proteins that are reported to carry out a variety of functions, many of which are unrelated to GPCR signalling. RGS proteins range in size from small proteins that contain little more than an RGS box to very large proteins that contain a variety of domains. The selectivity of function of the RGS proteins is attributable to the divergence of the RGS sequences as well as the presence of a variety of functional motifs, which allow them to interact with other proteins. Here we focus on the RGSs that are involved in modulating GPCR signalling by reviewing the diversity of the mechanisms involved in regulating these RGSs.

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Section: C/r7 Subfamilymentioning

confidence: 99%

Regulatory mechanisms involved in modulating RGS function

Jean-Baptiste

Yang

Greenwood

2006

Cell. Mol. Life Sci.

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“…GNB5 has also been demonstrated to complement a STE4 (G ) mutation in Sc. cerevisiae (Ajit and Young, 2004). This is, to our knowledge, the Wrst demonstration of functionality of the remaining human G subunits in yeast and also that all Wve are capable of acting as negative regulators of G signalling in such a system.…”

Section: Human G Subunits Can Complement a Gnr1 Mutationmentioning

confidence: 84%

Identification of Gnr1p, a negative regulator of Gα signalling in Schizosaccharomyces pombe, and its complementation by human Gβ subunits

Goddard

Ladds

Forfar

et al. 2006

Fungal Genetics and Biology

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Current awareness on yeast

2005

Yeast

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In order to keep subscribers up‐to‐date with the latest developments in their field, this current awareness service is provided by John Wiley & Sons and contains newly‐published material on yeasts. Each bibliography is divided into 10 sections. 1 Books, Reviews & Symposia; 2 General; 3 Biochemistry; 4 Biotechnology; 5 Cell Biology; 6 Gene Expression; 7 Genetics; 8 Physiology; 9 Medical Mycology; 10 Recombinant DNA Technology. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted. (5 weeks journals ‐ search completed 12th. Jan. 2005)

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Enhancement of pheromone response by RGS9 and Gβ5 in yeast

Cited by 6 publications

References 38 publications

Regulatory mechanisms involved in modulating RGS function

Regulatory mechanisms involved in modulating RGS function

Identification of Gnr1p, a negative regulator of Gα signalling in Schizosaccharomyces pombe, and its complementation by human Gβ subunits

Current awareness on yeast

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