Enhancement of pilot scale production of l(+)-lactic acid by fermentation coupled with separation using membrane bioreactor

Lu, Zhengdong; Mi, Wei; Yu, Liang

doi:10.1016/j.procbio.2011.11.022

Cited by 45 publications

(26 citation statements)

References 26 publications

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“…Otherwise, the separation steps are widely discussed in literature, such as precipitation (Rauch et al 1960;Min et al 2011;Kwak et al 2012;Nakano et al 2012), solvent extraction (Malmary et al 2000;Wasewar et al 2002;Matsumoto et al 2003;Yankov et al 2004;Alkaya et al 2009;Krzyzaniak et al 2013), membrane separation processes, and others. Membrane separation processes that have been studied include reverse osmosis, electrodialysis, and ultrafiltration (Kim and Moon 2001;Choi et al 2002;Madzingaidzo et al 2002;Li and Shahbazi 2006;González et al 2008;Ecker et al 2012;Lu et al 2012;Ramchandran et al 2012;Sikder et al 2012;Dey and Pal 2013;Pal and Dey 2013;Wang et al 2014).…”

Section: Separation and Purification Processesmentioning

confidence: 99%

Lactic Acid Production to Purification: A Review

Komesu

Oliveira

Martins

et al. 2017

BioRes

209

114

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Lactic acid is a naturally occurring organic acid that can be used in a wide variety of industries, such as the cosmetic, pharmaceutical, chemical, food, and, most recently, the medical industries. It can be made by the fermentation of sugars obtained from renewable resources, which means that it is an eco-friendly product that has attracted a lot of attention in recent years. In 2010, the U.S. Department of Energy issued a report that listed lactic acid as a potential building block for the future. Bearing the importance of lactic acid in mind, this review summarizes information about lactic acid properties and applications, as well as its production and purification processes.

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Section: Separation and Purification Processesmentioning

confidence: 99%

Lactic Acid Production to Purification: A Review

Komesu

Oliveira

Martins

et al. 2017

BioRes

209

114

View full text Add to dashboard Cite

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“…Cost of l(+)-lactic acid production was successfully reduced Lu et al 2012 Process Contribution Reference about two-thirds by the increase of yield and productivity. Twelve rounds of cell-recycle fermentations were successfully achieved in the pilot system.…”

Section: And Shahbazi 2006mentioning

confidence: 99%

Separation and Purification Technologies for Lactic Acid – A Brief Review

Komesu¹,

Maciel²,

Filho³

2017

BioResources

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Lactic acid is an important platform chemical with a wide range of applications. Production of lactic acid by fermentation is advantageous because renewable and low cost raw materials can be used as substrates. After fermentation, the broth needs to be purified to obtain pure lactic acid for further uses. Thus, efficient downstream processes are very important because they account for 50% of the production costs. This review discusses different processes that are currently employed for lactic acid recovery, focusing on precipitation, solvent extraction, and separation with membranes. Advances in such recovery processes and drawbacks that limit the application of these technologies at the industrial level are also presented.

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“…Lu et al used a pilot-scale bioreactor for lactic acid production comprising 3000 L of fermentor and an external ceramic microfiltration membrane to perform cell recycle. With repeated feeding medium used to alleviate substrate inhibition, pilot system with cell recycle was able to achieve lactic acid yield of 157 g/L and productivity of 8.8 g/L/h [108]. Recently, Zhang et al used Bacillus coagulans IPE22 to produce lactic acid from wheat hydrolysates, and to eliminate sequential utilization of sugars and product inhibition they used membrane integrated repeated batch fermentation (MIRB).…”

Section: Cell Recyclementioning

confidence: 99%

Engineered biosynthesis of biodegradable polymers

Jambunathan

Zhang

2016

Journal of Industrial Microbiology and Biotechnology

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Advances in science and technology have resulted in the rapid development of biobased plastics and the major drivers for this expansion are rising environmental concerns of plastic pollution and the depletion of fossil-fuels. This paper presents a broad view on the recent developments of three promising biobased plastics, polylactic acid (PLA), polyhydroxyalkanoate (PHA) and polybutylene succinate (PBS), well known for their biodegradability. The article discusses the natural and recombinant host organisms used for fermentative production of monomers, alternative carbon feedstocks that have been used to lower production cost, different metabolic engineering strategies used to improve product titers, various fermentation technologies employed to increase productivities and finally, the different downstream processes used for recovery and purification of the monomers and polymers.

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Enhancement of pilot scale production of l(+)-lactic acid by fermentation coupled with separation using membrane bioreactor

Cited by 45 publications

References 26 publications

Lactic Acid Production to Purification: A Review

Lactic Acid Production to Purification: A Review

Separation and Purification Technologies for Lactic Acid – A Brief Review

Engineered biosynthesis of biodegradable polymers

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