Enhancement of Platelet Aggregation in Patients with Nasopharyngeal Carcinoma

Huang, Guangwu; Nong, Huitu; Nakamura, Mariko; Kosugi, Tadayoshi

doi:10.1016/s0385-8146(12)80140-4

Cited by 6 publications

(5 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With regard to platelet function in patient with nasopharyngeal carcinoma‐our largest group‐findings were similar to those described previously 5 . This is an epidemic disease in South China and has a unique association with the Epstein‐Barr virus 22 .…”

Section: Discussionsupporting

confidence: 85%

“…This is an epidemic disease in South China and has a unique association with the Epstein‐Barr virus 22 . We have performed several hematological studies on nasopharyngeal carcinoma, 5,14,23 but it has remained unclear whether a specific mechanism of enhancement on platelet aggregation associated with Epstein‐Barr virus exists or whether related proteases expressed after the viral infection enhance platelet aggregation.…”

Section: Discussionmentioning

confidence: 99%

“…However, studies on the relationship between malignant tumors in the head‐neck region and functions of platelet aggregation are limited. In a preceding study, we reported on the enhancement of platelet aggregation in patients with nasopharyngeal carcinoma; that is, the maximum platelet aggregation rate (MAR) values in stages III and IV were found to be significantly enhanced compared with those of a control group and stage I and stage II disease 5 . The present retrospective study analyzes platelet aggregation in patients with head and neck tumors and explores the correlation of changes in platelet function with the clinical progress of malignant head and neck tumors.…”

Section: Introductionmentioning

confidence: 97%

See 2 more Smart Citations

Platelet Aggregation in Head and Neck Tumors in China

Huang¹,

Nong²,

Yu³

et al. 1997

The Laryngoscope

Self Cite

View full text Add to dashboard Cite

We measured the maximum aggregation rate (MAR) of platelets in 770 patients with malignant head and neck tumors, 55 patients with benign tumors of the head and neck, and 164 healthy people as a control group. The results were as follows: 1. the mean MAR value of patients with malignant tumors was significantly higher than the control group mean value; 2. prior to treatment, the mean MAR value increased with advancing tumor stage; 3. both MAR values of relapsed or metastasized patients and of nonsurvivors in stage III and IV increased significantly compared with survivors or patients recovering from malignant tumors. The results of the present study suggest that MAR values of patients with malignant tumors of the head and neck may serve as indicators in evaluating therapeutic procedures and prognosis.

show abstract

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Platelet Aggregation in Head and Neck Tumors in China

Huang¹,

Nong²,

Yu³

et al. 1997

The Laryngoscope

Self Cite

View full text Add to dashboard Cite

show abstract

“…Indeed, it has been clearly shown that adenocarcinomas (thyroid or salivary gland) have a higher thrombosis-associated risk than squamous cell carcinomas [52,53]. The same applies to nasopharyngeal carcinoma, which is a specific tumor that is very undifferentiated and is far from the typical H&N SCC that has a well-known high thrombosis-associated risk [54].…”

Section: The Lack Of Clinical Evidencementioning

confidence: 99%

Thrombosis Risk Associated with Head and Neck Cancer: A Review

Haen

Mège

Crescence

et al. 2019

IJMS

View full text Add to dashboard Cite

Venous thromboembolism (VTE) is a common complication for cancer patients. VTE-associated risk varies according to the type of tumor disease. Head and neck cancer is a common cancer worldwide, and most tumors are squamous cell carcinomas due to tobacco and alcohol abuse. The risk of VTE associated with head and neck (H&N) cancer is considered empirically low, but despite the high incidence of H&N cancer, few data are available on this cancer; thus, it is difficult to state the risk of VTE. Our review aims to clarify this situation and tries to assess the real VTE risk associated with H&N cancer. We report that most clinical studies have concluded that there is a very low thrombosis risk associated with H&N cancer. Even with the biases that often exist, this clinical review seems to confirm that the risk of VTE was empirically hypothesized. Furthermore, we highlight that H&N cancer has all the biological features of a cancer associated with a high thrombosis risk, including a strong expression of procoagulant proteins, modified thrombosis/fibrinolysis mechanisms, and secretions of procoagulant microparticles and procoagulant cytokines. Thus, this is a paradoxical situation, and some undiscovered mechanisms that could explain this clinical biological ambivalence might exist.

show abstract

“…Previous investigations revealed that distant dissemination of NPC was frequent and associated with increased platelet aggregation (Huang et al 1994). Selectins or other adhesion molecules on platelets can tether tumor cells, causing them to adhere firmly on the activated ECs under blood shear flow, and eventually to colonize distant organs, resulting in metastatic dissemination (Grossi et al 1988;Borsig 2004;Burdick and Konstantopoulos 2004;Lawler et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Exercise affects platelet-promoted tumor cell adhesion and invasion to endothelium

Chen

2008

Eur J Appl Physiol

View full text Add to dashboard Cite

This investigation explored how exercise intensity impacts platelet-mediated interactions of nasopharyngeal carcinoma cells (NPCs) and vascular endothelial cells (ECs) under shear flow in 33 males. Our results showed that (a) platelet-NPC aggregates (PNA) were associated with higher shear-induced P-selectin expression and glycoprotein alpha(II)beta(3) activation than platelet-platelet aggregates (PPA); (b) strenuous exercise (SE, up to VO2max), but not moderate exercise (ME, 60% VO2max for 30 min), increased both PPA and PNA in mimicked venous and arterial circuits and enhanced PNA in mimicked flow of stenotic vessels; (c) the percentages of PNA that remained bound to ECs in mimicked flow of post-capillary venules increased, while platelet-induced CD44 cleavage on NPC and trans-endothelial migration of NPC were enhanced following SE, but were unchanged in response to ME. We conclude that SE, but not ME, enhances the capacity of PNA to adhere to ECs, withstand flowing blood, and facilitate the invasion of NPCs toward ECs.

show abstract

Enhancement of Platelet Aggregation in Patients with Nasopharyngeal Carcinoma

Cited by 6 publications

References 5 publications

Platelet Aggregation in Head and Neck Tumors in China

Platelet Aggregation in Head and Neck Tumors in China

Thrombosis Risk Associated with Head and Neck Cancer: A Review

Exercise affects platelet-promoted tumor cell adhesion and invasion to endothelium

Contact Info

Product

Resources

About