Enhancement of port site metastasis by hyaluronic acid under CO2 pneumoperitoneum in a murine model

Abstract

Under CO2 pneumoperitoneum, exogenous hyaluronic acid increased the frequency and weight of port site metastasis in a murine model. Hyaluronic acid secreted from mesothelial cells may be associated with the formation of port site metastasis after laparoscopic surgery for cancer under pneumoperitoneum.

Laparoscopic enhancement of tumour cell binding to the peritoneum is inhibited by anti?intercellular adhesion molecule-1 monoclonal antibody

“…Previously, Yamaguchi et al [31] had investigated the effect of the pneumoperitoneum on the peritoneum using a small animal model. They showed that exogenous hyaluronan enhanced PSM formation.…”

Peritoneal nebulizer: a novel technique for delivering intraperitoneal therapeutics in laparoscopic surgery to prevent locoregional recurrence

“…It also affects the inflammatory reaction of leukocytes and downregulates endothelial ICAM-1 expression [10,12,14]. On the other hand, the ability of hyaluronic acid to block tumor adhesion has been questioned because of its contradicting affect on tumor-mesothelium adhesion [5,17].…”

Development of port-site metastasis after pneumoperitoneum

“…We used BAEB/c nude mice and a human gastric cancer cell line because port-site metastasis is known to develop frequently in these mice [19], and the cancer cells can be easily recognized under microscopic observation.…”