Enhancement of prenatal development by operative restriction of litter size in the rabbit

Marthens, Edith van; Grauel, Ludmila; Zamenhof, Stephen

doi:10.1016/0024-3205(72)90183-x

Cited by 19 publications

(9 citation statements)

References 8 publications

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“…A subsequent study in the rabbit revealed that litter restriction to one, results in even more pronounced increases in the above measurements. Placental weight was increased by up to 105 % (6). The correlation between placental weight and other aspects o f fetal development has previously been reported by us (13).…”

supporting

confidence: 67%

“…The developmental potentiality of the individual fetus can be restricted by factors such as space conditions in the uterus (large litter size) (6), availability o f nutrients (maternal undernutrition) (11,12), fetal utilization o f nutrients, and decreased blood sup ply to the fetus (eclampsia) (7,9). A considerable amount of research has been directed towards one or more o f the factors restricting fetal growth.…”

mentioning

confidence: 99%

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Ovarian, Adrenal and Litter Restriction Effects on Fetal and Placental Development

Marthens¹,

Grauel²

1974

Ann Nutr Metab

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Surgical litter restriction to one to five fetuses per rat, results in highly significant increases in fetal body and placental weight. Intrauterine crowding, competition, and the amount of nutrients available per fetus appear to be the limiting factors controlling fetal development. The interaction of ovarian and adrenal hormones was investigated by surgical removal of ovarian and adrenal tissue during litter restriction. Increased intrauterine growth does not appear to be directly controlled by the amount of ovarian and/or adrenal tissue per fetus.

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supporting

confidence: 67%

mentioning

confidence: 99%

Ovarian, Adrenal and Litter Restriction Effects on Fetal and Placental Development

Marthens¹,

Grauel²

1974

Ann Nutr Metab

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“…It can be seen that this restriction resulted in highly significant mean increases in body and placental weight, as well as cerebral weight, DNA and protein. (Compare also [2].) It is of interest that the highest increases (up to 62%) were for placental weight and they followed the degree of litter restriction (first column).…”

Section: Results Und Discussionmentioning

confidence: 96%

“…A subsequent study [2] in the rabbit revealed that litter restriction to one results in even more pro nounced increases in the above parameters, as well as in placental weight.…”

Section: Introductionmentioning

confidence: 95%

Enhancement of Prenatal Development in the Rat by Operative Restriction of Litter Size

1974

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“…Marked placental and somatic hypertrophy follow reduction in litter size if surgery is performed early in gestation [12]. Hormonal mechanisms involving ovarian-placental interaction or general systemic effects related to less uterine crowding and improved maternal blood supply to individual placentae, have been invoked to explain this phenomenon [26].…”

Section: Discussionmentioning

confidence: 99%

The relationship of body and placental weight to plasma leavels of insulin and other hormones during development in fetal rabbits

Fletcher¹,

Falconer²,

Bassett³

1982

Diabetologia

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The relationship of body and placental weight with plasma levels of insulin, glucose, glucagon, glucocorticoids and somatomedins in fetal rabbits between 22 days of gestation and term has been investigated. At 22, 24, 26, 28 and 30 days gestation, body and placental weights were strongly correlated and were also significantly correlated with log transformed plasma insulin concentrations in individual fetuses from nulliparous does. At 30 days gestation, mean plasma insulin levels, as well as body and placental weights, were significantly elevated in fetuses from multiparous does (p less than 0.05) and in fetuses whose growth had been increased by surgical reduction in litter size on day 9 of pregnancy (p less than 0.001). Log insulin concentrations in fetuses from multiparous does and in litter-reduced fetuses were also significantly correlated with bodyweight. The correlation coefficient for log insulin and bodyweight in all individual rabbit fetuses at 30 days gestation was 0.69 (p less than 0.001, n = 116). Fetal log plasma glucagon concentrations at 26 and 28 days gestation were negatively correlated with body weight, but were not significantly related at 30 days gestation. Neither glucose nor glucocorticoid concentrations were significantly related to bodyweight in individual fetuses. Plasma somatomedin activity in litter-reduced fetuses at 30 days gestation, was significantly higher (p less than 0.02) than in normal fetuses, but was not significantly correlated with fetal body weight. The observation of strong positive correlation between insulin and bodyweight throughout the last third of gestation reinforces the belief that fetal insulin plays an important role in the regulation of both placental and fetal growth.

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Enhancement of prenatal development by operative restriction of litter size in the rabbit

Cited by 19 publications

References 8 publications

Ovarian, Adrenal and Litter Restriction Effects on Fetal and Placental Development

Ovarian, Adrenal and Litter Restriction Effects on Fetal and Placental Development

Enhancement of Prenatal Development in the Rat by Operative Restriction of Litter Size

The relationship of body and placental weight to plasma leavels of insulin and other hormones during development in fetal rabbits

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