Enhancement of Purified Human Colon Cancer-Specific Parasporal Toxin from Bacillus thuringiensis-LDC-501

Gut microbiota dysbiosis signature is associated with the colorectal carcinogenesis sequence and improves the diagnosis of colorectal lesions

“…30,31 Recently, purified proteins from B. thuringiensis have been studied for use in cancer therapy. 32 In addition, we identified multiple CRC-associated pathogens or pathobionts that have not been previously reported, such as Streptococcus constellatus, Gemella morbillorum, Prevotella nigrescens, C. ramosum, Streptococcus pneumoniae, Fusobacterium necrophorum, and B. cereus. G. morbillorum is also considered to induce endocarditis and is associated with colonic neoplasms.…”

“…B. thuringiensis is a specific bacterium that has been widely used in the agriculture and public health fields and also may be a pathobiont that is associated with severe necrosis in humans 30,31 . Recently, purified proteins from B. thuringiensis have been studied for use in cancer therapy 32 . In addition, we identified multiple CRC‐associated pathogens or pathobionts that have not been previously reported, such as Streptococcus constellatus , Gemella morbillorum , Prevotella nigrescens , C. ramosum , Streptococcus pneumoniae , Fusobacterium necrophorum , and B. cereus .…”