ZnO tetrapods modified by TiO 2 powder are synthesized using a simple fast thermal oxidation method, and theirs CO sensing properties are investigated. The ZnO tetrapods modified by TiO 2 powder sensor is tested at 250-400 C under different CO concentrations compared with pure ZnO tetrapods, ZnO nanoparticle, and ZnO powder sensors. With a good crystallinity and a high pore size, the ZnO tetrapods modified by TiO 2 powder sensor shows the highest sensing response compared to other sensors, exhibiting a size-independent property for CO. Additionally, the response time of ZnO tetrapods modified by TiO 2 powder sensor is reduced. The improvement of the sensing properties is attributed to microstructure, lattice, surface area, and conductance modification of TiO 2 additive together with a high diffusion process deeply inside the sensing layer through the large pore size.