Enhancement of serum lipoprotein lipase mass levels by intensive insulin therapy

Miyashita, Yoh; Ebisuno, Mariko; Ohhira, Masahiro; Endoh, Kei; Saiki, Atsuhito; Koide, Nobukiyo; Ohtsuka, Masaki; Oyama, Tomokazu; Shirai, Kohji

doi:10.1016/j.diabres.2005.09.016

Cited by 9 publications

(4 citation statements)

References 26 publications

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“…However, this may overestimate lipolysis, since VLDL hydrolysis will contribute to glycerol Ra. Although this will be a small percentage of total glycerol Ra in the fasting state, during an hyperinsulinaemic clamp this contribution may increase, since insulin increases lipoprotein lipase mass and activity [35,36]. Measurement of NEFA Ra using an isotope of one of the more abundant circulating fatty acids such as palmitic acid or oleic acid has also been used as a measure of whole-body lipolysis, although this may lead to an underestimation of lipolysis due to intracellular recycling of fatty acids into triacylglycerol.…”

Section: Discussionmentioning

confidence: 99%

Exercise training reduces fatty acid availability and improves the insulin sensitivity of glucose metabolism

et al. 2006

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Aims/hypothesis It is not known whether the beneficial effects of exercise training on insulin sensitivity are due to changes in hepatic and peripheral insulin sensitivity or whether the changes in insulin sensitivity can be explained by adaptive changes in fatty acid metabolism, changes in visceral fat or changes in liver and muscle triacylglycerol content. We investigated the effects of 6 weeks of supervised exercise in sedentary men on these variables. Subjects and methods We randomised 17 sedentary overweight male subjects (age 50±2.6 years, BMI 27.6±0.5 kg/ m 2 ) to a 6-week exercise programme (n=10) or control group (n=7). The insulin sensitivity of palmitic acid production rate (Ra), glycerol Ra, endogenous glucose Ra (EGP), glucose uptake and glucose metabolic clearance rate were measured at 0 and 6 weeks with a two-step hyperinsulinaemic-euglycaemic clamp [step 1, 0.3 (low dose); step 2, 1.5 (high dose) mU kg −1 min −1 ]. In the exercise group subjects were studied >72 h after the last training session. Liver and skeletal muscle triacylglycerol content was measured by magnetic resonance spectroscopy and visceral adipose tissue by cross-sectional computer tomography scanning. Results After 6 weeks, fasting glycerol, palmitic acid Ra (p=0.003, p=0.042) and NEFA concentration (p=0.005) were decreased in the exercise group with no change in the control group. The effects of low-dose insulin on EGP and of high-dose insulin on glucose uptake and metabolic clearance rate were enhanced in the exercise group but not in the control group (p=0.026; p=0.007 and p=0.04). There was no change in muscle triacylglycerol and liver fat in either group. Conclusions/interpretation Decreased availability of circulating NEFA may contribute to the observed improvement in the insulin sensitivity of EGP and glucose uptake following 6 weeks of moderate exercise.

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Section: Discussionmentioning

confidence: 99%

Exercise training reduces fatty acid availability and improves the insulin sensitivity of glucose metabolism

et al. 2006

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“…In early clinical studies, LPL levels were analyzed using postheparin plasma (Sexena U et al, 1989;Peterson et al,1990). However, a sensitive immunoassay using a specific monoclonal antibody against LPL has demonstrated the presence of LPL mass in preheparin serum (Kobayashi J et al, 1993;Tornvall P et al, 1995).Preheparin LPL massis low in type 2 diabetes patients and is increased by insulin therapy (Miyashita Y et al, 2002).Preheparin LPL mass is considered to reflectinsulin action in the whole body (Miyashita Y et al, 2006).These reports indicate that preheparin LPL mass is a good marker for evaluating insulin action. In this study, although the change inpreheparin LPL mass was not significantly different between two groups, mean preheparin LPL mass increased in degludec group but decreased in glargine group.…”

Section: Discussionmentioning

confidence: 99%

Insulin Degludecimproves Blood Glucose But Does Not Alter Arterial Stiffness in Type 1 Diabetes Patients

Ohira¹,

Saiki²,

Nagumo³

et al. 2015

IJMP

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Background: Type 1 diabetes mellitus (T1DM) is characterized by insulin deficiency.Insulin degludec is newly developed ultra-long-acting insulin analog. However, the effect of insulin degludec on the artery is unclear. Aim:To study the efficacy of insulin degludec on artery. Methods: 28T1DM patients already onbasalbolus insulin therapy were enrolled.Patients were divided into a group that switched from insulin glargine to insulin degludec (degludec group, n=14) and a group that continued to inject insulin glargine (glargine group, n=14).We observed the change in cardio-ankle vascular index (CAVI) that reflects arterial stiffness. Results: After 6 months,degludecsignificantly improved fasting blood glucose (FBG;-95.57 ± 93.06 mg/dl, P < 0.005) and hemoglobin A1c (HbA1c:-0.73 ± 0.53 %, P < 0.0005).The decreasesinFBG and HbA1c in degludec groupwere significantly differentfrom the changesin glarginegroup (FBG:-95.57 ± 93.06 mg/dl vs+23.21 ± 70.44 mg/dl, P < 0.01; HbA1c:-0.73 ± 0.53 % vs-0.03 ± 0.75 %, P < 0.01).The changeinCAVIwas not significantly different between two groups. Conclusion:These results suggest that switching from insulin glargine to insulin degludec improves blood glucose, but does not ameliorate arterial stiffness.

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“…Importantly, non‐HDL cholesterol has been shown to have a strong predictive power for future cardiovascular disease even from childhood . Intensified insulin treatment is known to enhance the action of lipoprotein lipase, leading to increased HDL cholesterol levels in people with Type 1 diabetes . Furthermore, low HDL cholesterol levels do not seem to persist through adulthood .…”

Section: Introductionmentioning

confidence: 99%

Lipid profile is associated with treatment regimen in a large cohort of children and adolescents with Type 1 diabetes mellitus: a study from the international SWEET database

et al. 2019

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Aims To examine the effect of pump vs injection therapy on the lipid profile of children with Type 1 diabetes mellitus.Methods A cross-sectional analysis of the lipid profile of children aged ≤ 18 years with Type 1 diabetes mellitus from SWEET, an international diabetes registry, was conducted with a focus on the effect of treatment regimen. Dyslipidaemia was defined as LDL cholesterol ≥2.6 mmol/l or non-HDL cholesterol ≥3.1 mmol/l. LDL and non-HDL cholesterol values among 14 290 children (52% boys, 51% receiving pump therapy) from 60 SWEET centres were analysed by linear and logistic regression analysis adjusted for sex, age, diabetes duration, HbA 1c and BMI-standard deviation score group, region, and common interactions between age, sex, HbA 1c and BMI.Results This study confirmed the established associations of increased lipids with female sex, age, diabetes duration, HbA 1c and BMI. LDL and non-HDL cholesterol levels were lower in the pump therapy group compared to the injection therapy group [LDL cholesterol: injection therapy 2.44 mmol/l (95% CI 2.42 to 2.46) vs pump therapy 2.39 mmol/l (95% CI 2.37-2.41), P<0.001; non-HDL cholesterol: injection therapy 2.88 mmol/l (95% CI 2.86 to 2.90) vs pump therapy 2.80 mmol/l (95% CI 2.78-2.82), both P<0.0001]. Similarly, the odds ratios for LDL cholesterol ≥2.6 mmol/l [0.89 (95% CI 0.82-0.97)] and non-HDL cholesterol ≥3.1 mmol/l [0.85 (0.78 to 0.93)] were significantly lower in the pump therapy group, even after all adjustments. ConclusionsOur results indicate that pump therapy is associated with a better lipid profile.

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Enhancement of serum lipoprotein lipase mass levels by intensive insulin therapy

Cited by 9 publications

References 26 publications

Exercise training reduces fatty acid availability and improves the insulin sensitivity of glucose metabolism

Exercise training reduces fatty acid availability and improves the insulin sensitivity of glucose metabolism

Insulin Degludecimproves Blood Glucose But Does Not Alter Arterial Stiffness in Type 1 Diabetes Patients

Lipid profile is associated with treatment regimen in a large cohort of children and adolescents with Type 1 diabetes mellitus: a study from the international SWEET database

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