Enhancement of Solubility and Dissolution Rate of Curcumin by Solid Dispersion Technique

“…In fact, the keto form is predominant in acid and neutral media (3<pH<7) and acts as H‐atom donor. However, in basic media pH>8, the enol form is predominant and act as electron donor . The pH is one of the important factors that affects the size/composition of NPs.…”

Section: Resultsmentioning

confidence: 99%

Green Synthesis of Curcumin Conjugated CuO Nanoparticles for Catalytic Reduction of Methylene Blue

2020

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A novel simple green synthesis route was applied to produce copper oxide (CuO) nanoparticles (NPs) and CuO nanograins (NGs) by using cupric chloride dihydrated as copper salt precursor, curcumin (a natural and non-toxic food spice) as conjugated agent with or without cetyl trimethylammonium bromide acting as a stabilizing agent at extreme basic condition. Synthesis of this curcumin conjugated CuO nanoparticles was optimized by studying effect of several parameters starting with copper salt precursor, curcumin concentration, pH and temperature. Scanning electron microscopy coupled to Energy Dispersive X-ray Analyzer, thermogravimetirc analysis, X-ray diffraction, UV-visible spectroscopy, fluorescence spectroscopy and zeta potential were used to characterize the resulted CuO NPs/NGs. In this work, the synthesized copper oxide nanograins were found to be efficient nano-catalysts for the reduction of methylene blue and it was found that nanograin has better catalytic activity compared to spherical shape nanoparticles, emphasizing shape of the CuO particles is crucial for its nanocatalytic activity.

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“…Then the cylinder was tapped from a height of 1 cm until the time were there was no decrease in the final volume. The bulk density (ρB) and tapped density (ρT) of plain GLB and SDs were determined, Carr's index and Hausner's ratio were calculated using ρB and ρT values as shown below [26].…”

Section: 6mentioning

confidence: 99%

Preparation and evaluation of glibenclamide binary solid dispersions prepared by fusion and solvent-fusion method

2019

Biointerface Res Appl Chem

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Solid dispersions (SDs) of the poorly water soluble antidiabetic drug, glibenclamide(GLB), were prepared using polyethylene glycol 4000(PEG) through the fusion and solvent-fusion method. Solid-state analysis and the in vitro drug release profiles of the prepared formulations were assessed. Compressibility and flowability of the prepared solid dispersions were also evaluated. The dissolution rate of the prepared SDs was greatly superior to GLB. The release profile was more dependent on drug to hydrophilic polymer ratio than the preparation technique. The FTIR studies showed no interaction between drug and polymer. DSC thermograms of the prepared SDs showed no endothermic peak of GLB, which could be attributed to the gradual dissolving of the GLB in the melted PEG and/or drug amorphization. Moreover, prepared SDs were showed superior compressibility and flowability. According to the obtained results, GLB/PEG SDs both prepared successfully by fusion and solvent-fusion technique and showed improved flowability and dissolution. This will likely lead to an increase in drug bioavailability and glucose control performance in diabetic patients. There was no significant difference between the obtained result from fusion and solvent-fusion method. However, due to the lack of organic solvent as well as simple and economical manufacturing process fusion method is more reasonable.

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Enhancement of Solubility and Dissolution Rate of Curcumin by Solid Dispersion Technique

Cited by 27 publications

References 17 publications

Development and evaluation of gastroretentive raft forming systems incorporating curcumin-Eudragit® EPO solid dispersions for gastric ulcer treatment

Development and evaluation of gastroretentive raft forming systems incorporating curcumin-Eudragit® EPO solid dispersions for gastric ulcer treatment

Green Synthesis of Curcumin Conjugated CuO Nanoparticles for Catalytic Reduction of Methylene Blue

Preparation and evaluation of glibenclamide binary solid dispersions prepared by fusion and solvent-fusion method

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