Enhancement of tendon graft osteointegration using mesenchymal stem cells in a rabbit model of anterior cruciate ligament reconstruction

Lim, Jimmy; Hui, James Hoi Po; Li, Li; Thambyah, Ashvin; Goh, James Cho Hong; Lee, Eng-Hin

doi:10.1016/j.arthro.2004.06.035

Cited by 162 publications

(151 citation statements)

References 38 publications

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“…In addition, placement in a tunnel increases tendon exposure to mesenchymal stem cells, which may be the source of tendon or bone cells needed to achieve healing and which have been reported to enhance osteointegration of tendon grafts in rabbits. 12 A potential disadvantage is that bone loss in the region of the repair site, which has been documented for FDP tendon surface repairs, 13 may be exacerbated following the surgical trauma of creating a bone tunnel large enough to accommodate the tendon.…”

Section: Introductionmentioning

confidence: 99%

Early healing of flexor tendon insertion site injuries: Tunnel repair is mechanically and histologically inferior to surface repair in a canine model

Silva

Thomopoulos

Kusano

et al. 2006

Journal Orthopaedic Research

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Orthopedic injuries often require surgical reattachment of tendon to bone. Tendon ends can be sutured to bone by direct apposition to the bone surface or by placement within a bone tunnel. Our objective was to compare early healing of a traditional surface versus a novel tunnel method for repair of the flexor digitorum profundus (FDP) tendon insertion site in a canine model. A total of 70 tendon-bone specimens were analyzed 0, 5, 10 or 21 days after injury and repair, using tensile and range of motion mechanical testing, histology and densitometry. Ultimate force (a measure of repair strength) did not differ between surface and tunnel repairs at day 0. Both repair types had reduced strength at 10 and 21 days compared to 0 days, indicative of deterioration of suture grasping strength (tendon softening). At 21 days, tendons repaired in a bone tunnel had 38% lower ultimate force compared to surface repairs (p ¼ 0.017). Histological findings were comparable between repair groups at 5 and 10 days but differed at 21 days, when we saw evidence of maturation of the tendonbone interface in the surface repairs compared to an immature fibrous interface with no evidence of tendon-bone integration in the tunnel repairs. After accounting for bone removed by the tunnel, no difference in bone mineral density or trabecular bone volume existed between surface and tunnel repairs. If the results of our animal study extend to healing of the human FDP insertion, they indicate that FDP tendons should be reattached to the distal phalanx by suture to the cortical surface rather than suture in a bone tunnel. ß

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Section: Introductionmentioning

confidence: 99%

Early healing of flexor tendon insertion site injuries: Tunnel repair is mechanically and histologically inferior to surface repair in a canine model

Silva

Thomopoulos

Kusano

et al. 2006

Journal Orthopaedic Research

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“…BMSCs that were implanted in rabbit Achilles tendon repair sites were found to contribute to early tendon healing (Chong et al, 2007). BMSCs can also be used clinically to augment healing at the bone-tendon interface after procedures such as anterior cruciate ligament reconstruction (Lim et al, 2004).…”

Section: Tendons and Ligamentsmentioning

confidence: 99%

Updates on stem cells and their applications in regenerative medicine

Bajada

Mazakova

Richardson

et al. 2008

J Tissue Eng Regen Med

310

188

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“…Another application of BM consists of BM stem cell auto-transplantation at the ischaemic lower limb, which resulted in an improvement of the peripheral blood flow and percutaneous oxygen partial pressure [80]. Moreover, BM and its osteoprogenitors were used in spinal fusion [22,73], osteonecrosis of the femoral head [30, 31, 46], bone cysts [14], osteochondral defects [13], tendon osteointegration [62], and in facilitation of nerve repair [12,120].…”

Section: Bone Marrow Injectionmentioning

confidence: 99%

Efficacy of minimally invasive techniques for enhancement of fracture healing: evidence today

Pountos

Georgouli

Kontakis

et al. 2009

International Orthopaedics (SICOT)

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The successful treatment of nonunions represents a major challenge for orthopaedic surgeons. Lately, ongoing advances made in the field of molecular medicine and molecular biology have increased our understanding of the pathways and involvement of mediators surrounding the bone healing process. As a result, the surgeon's armamentarium has been increased in terms of options for intervention. This article aims to provide an overview of minimally invasive techniques applicable in the treatment of nonunions of fractures.

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Enhancement of tendon graft osteointegration using mesenchymal stem cells in a rabbit model of anterior cruciate ligament reconstruction

Cited by 162 publications

References 38 publications

Early healing of flexor tendon insertion site injuries: Tunnel repair is mechanically and histologically inferior to surface repair in a canine model

Early healing of flexor tendon insertion site injuries: Tunnel repair is mechanically and histologically inferior to surface repair in a canine model

Updates on stem cells and their applications in regenerative medicine

Efficacy of minimally invasive techniques for enhancement of fracture healing: evidence today

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