Enhancement of the antiemetic action of ondansetron by transcutaneous electrical stimulation of the P6 antiemetic point, in patients having highly emetic cytotoxic drugs

McMillan, C.; Dundee, J. W.; Abram, W. P.

doi:10.1038/bjc.1991.439

Cited by 24 publications

(8 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to the scale used by McMillan et al [12] complete response was achieved in 56% of the cases in the TENS + ondansetron group whereas only 4% had a complete response in the TENS only group and 12% in the ondansetron group (table 3). Most of the patients (64%) in the ondansetron group had a major response.…”

Section: Resultsmentioning

confidence: 99%

“…Thus TENS only seems inadequate for the prevention of cisplatin-induced emesis. While acupressure alone produced little benefit in cisplatin-induced emesis, TENS was reported to have a synergistic action with antiemetic drugs such as metoclopramide and ondansetron in the prevention of emesis caused by cytotoxic drugs [12,18,22]. Saller et al [22] observed that TENS enhanced the antiemetic action of metoclopramide against cisplatininduced emesis in 10 of 11 treatment pairs that were studied.…”

Section: Discussionmentioning

confidence: 99%

“…Saller et al [22] observed that TENS enhanced the antiemetic action of metoclopramide against cisplatininduced emesis in 10 of 11 treatment pairs that were studied. Similarly, McMillan et al [12] showed that 75% of the cases obtained some extra benefit from addition of TENS to ondansetron in a series of 16 patients receiving cytotoxic drugs. In our study we found that although ondansetron was effective in preventing cisplatin-induced emesis, the use of TENS as an adjunct resulted in even better antiemesis.…”

Section: Discussionmentioning

confidence: 99%

“…Then the nausea and emesis scores of each regimen were compared. Finally the response to TENS, ondansetron and the TENS + ondansetron combination was evaluated according to a scale used by McMillan et al [12]. According to the scale '0' emetic episodes/day was considered as complete; 1-2 episodes/day as major, and 3-5 episodes/day as minor responses.…”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Combination of Transcutaneous Electrical Nerve Stimulation and Ondansetron in Preventing Cisplatin-Induced Emesis

et al. 2001

View full text Add to dashboard Cite

Objective: To find out whether the combination of transcutaneous electrical nerve stimulation (TENS) and ondansetron had an increased antiemetic effect. Materials and Methods: Fourteen testis and 11 bladder cancer patients were scheduled for 4 cycles of bleomycin-etoposide-cisplatin (BEP) or methotrexate-vinblastine-etoposide-cisplatin (MVEC) combination chemotherapy, respectively. At each cycle the whole cisplatin dose was given in 1 day that is 100 mg/m²/day in the BEP and 70 mg/m²/day in the MVEC protocols. Ondansetron was given at a dose of 12 mg/day and TENS was applied by commercially available ‘Relief Band’(Maven Labs, Inc., Citrus Heights, Calif., USA). The first 3 cycles of each case were blindly randomized to one of the following regimens; TENS vs. ondansetron vs. a combination of both. The regimens were applied during the administration of cisplatin and the patients were asked to report their nausea according to a scale between 0 to 10. Also for each regimen the number of emetic attacks experienced during the administration of cisplatin was recorded by the same observer. Then the scores of each regimen were compared. Results: The mean nausea scores for regimens TENS, ondansetron and TENS + ondansetron were found to be 5.12 ± 2.54, 3.0 ± 1.71 and 0.8 ± 0.96, respectively. Ondansetron was better than TENS in preventing nausea (p = 0.000). However the combination of TENS and ondansetron resulted in a significant decrease in nausea scores when compared to TENS alone (p = 0.000) or ondansetron alone (p = 0.000). The mean number of emetic attacks for the TENS, ondansetron and TENS + ondansetron regimens were 3.16 ± 1.84, 1.64 ± 1.44 and 0.56 ± 0.82, respectively. A statistically significant difference was present between the number of emetic attacks observed with the TENS + ondansetron combination and TENS alone (p = 0.000) or ondansetron alone (p = 0.001). Ondansetron was again better than TENS in preventing emetic attacks (p = 0.001). Conclusion: The use of TENS as an adjunct to ondansetron therapy has provided significant benefit in preventing nausea and emetic attacks caused by cisplatin.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Combination of Transcutaneous Electrical Nerve Stimulation and Ondansetron in Preventing Cisplatin-Induced Emesis

et al. 2001

View full text Add to dashboard Cite

show abstract

“…Most trials on acupressure did not show significant protective effects on the control of acute nausea and vomiting or delayed symptoms (14,15). Only a few studies (16)(17)(18) suggested the antiemetic effects of acupressure in postchemotherapy patients.…”

Section: The Use Of Acupuncture In Controlling Chemotherapy-induced Nmentioning

confidence: 99%

Acupuncture as a Complementary Therapy in Chemotherapy-Induced Nausea and Vomiting

2009

Baylor University Medical Center Proceedings

View full text Add to dashboard Cite

Acupuncture and Moxibustion as an Evidence-based Therapy for Cancer

Cho¹

2012

Evidence-Based Anticancer Complementary and Alternative Medicine

View full text Add to dashboard Cite

Enhancement of the antiemetic action of ondansetron by transcutaneous electrical stimulation of the P6 antiemetic point, in patients having highly emetic cytotoxic drugs

Cited by 24 publications

References 6 publications

Combination of Transcutaneous Electrical Nerve Stimulation and Ondansetron in Preventing Cisplatin-Induced Emesis

Combination of Transcutaneous Electrical Nerve Stimulation and Ondansetron in Preventing Cisplatin-Induced Emesis

Acupuncture as a Complementary Therapy in Chemotherapy-Induced Nausea and Vomiting

Acupuncture and Moxibustion as an Evidence-based Therapy for Cancer

Contact Info

Product

Resources

About