Enhancement of the blood-circulation time and performance of nanomedicines via the forced clearance of erythrocytes

Nikitin, Maxim P.; Zelepukin, Ivan V.; Shipunova, Victoria O.; Sokolov, I. L.; Deyev, Sergey M.; Никитин, П. И.

doi:10.1038/s41551-020-0581-2

Cited by 116 publications

(93 citation statements)

References 61 publications

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“…Theterm "MPS" refers to acollection of multiple cells including bone marrow progenitors,b lood monocytes and tissue macrophages,which would be activated by non-endogenous species and responsible for eliminating those foreign nanoparticles.L iver, spleen, and kidneys are some of the largest MPS units in human body and thus explain the substantial liver/spleen/kidney deposition of non-modified PDA-based nanoparticles. [24] To avoid the capture and clearance by MPS,here we modified the nanoplatforms with hydrophilic PEG 1500 ,which could form ahydrated layer at the nanoparticle surface for steric stabilization and reduce MPS capture.T he biodistribution profile also showed that Fe II PDA@IR780-PEG-cRGD accumulation reached maximum at around 8hafter administration (Figure 6a;Supporting Information, Figure S18a-c). Consequently,the nanoplatform-mediated photothermal efficacy in vivo was determined by irritating the tumor region with NIR laser (808 nm, 5min) at the 8hpost i.v.i njection, which was recorded using an IR thermographic camera.…”

Section: Angewandte Chemiementioning

confidence: 99%

NIR‐Actuated Remote Activation of Ferroptosis in Target Tumor Cells through a Photothermally Responsive Iron‐Chelated Biopolymer Nanoplatform

et al. 2021

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Ferroptosis is anew form of regulated cell death that shows promise for tumor treatment. Most current ferroptosis tumor therapies are based on the intrinsic pathological features of the malignancies,and it would be of clinical significance to develop ferroptosis-inducing strategies with improved tumor specificity and modulability.Here we report ap olydopaminebased nanoplatform (Fe II PDA@LAP-PEG-cRGD) for the efficient loading of Fe 2+ and b-lapachone (LAP), which could readily initiate ferroptosis in tumor cells upon treatment with near-infrared light. PDAn anostructures could generate mild hyperthermia under NIR irritation and trigger the release of the ferroptosis-inducing Fe 2+ ions.T he NIR-actuated photothermal effect would also activate cellular heat shock response and upregulate the downstream NQO1 via HSP70/NQO1 axis to facilitate bioreduction of the concurrently released b-lapachone and enhance intracellular H 2 O 2 formation to promote the Fe 2+ -mediated lipid peroxidation.

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Section: Angewandte Chemiementioning

confidence: 99%

NIR‐Actuated Remote Activation of Ferroptosis in Target Tumor Cells through a Photothermally Responsive Iron‐Chelated Biopolymer Nanoplatform

et al. 2021

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“…with cells. [36][37][38][39] Data presented in Figure 8 were obtained using Amnis ImageStream X Mark II imaging flow cytometer. ImageStream, unlike conventional cytometers, employs in its optical systems a time-delay integration-CCD camera, 40 which takes photos of objects in the flow instead of detection of scattered light.…”

Section: Impact Of Rc Mps On Tumor Cells In Culturementioning

confidence: 99%

Radachlorin-Containing Microparticles for Photodynamic Therapy

et al. 2020

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Purpose: Reducing the undesirable systemic effect of photodynamic therapy (PDT) can be achieved by incorporating a photosensitizer in microparticles (MPs). This study is devoted to the preparation of biocompatible biodegradable MPs with the inclusion of the natural photosensitizer Radachlorin (RС) and an assessment of the possibility of their use for PDT. Methods: RC-containing MPs (RС MPs) with poly(lactic-co-glycolic acid) copolymer (PLGA) matrix were prepared by a double emulsion solvent evaporation methods. The size and morphology of RC MPs were surveyed using scanning electron microscopy, confocal laser scanning microscopy, and dynamic light scattering. The content of RC, its release from RC MPs, and singlet oxygen generation were evaluated by the optical spectroscopy. Cellular uptake and cytotoxic photodynamic effect of RC MPs were investigated with in vitro assays. Results: The average diameter of the prepared RC MPs was about 2-3 μm. The RC MPsprepared by the water/oil/oil method had a significantly higher inclusion of RC (1.74 μg/mg) then RC MPs prepared by the water/oil/water method (0.089 μg/mg). Exposure of the prepared RC MPs to PDT light radiation was accompanied by the singlet oxygen generation and a cytotoxic effect for tumor cells. The release of the RC from the RC MPs was prolonged and lasted at least two weeks. Conclusion: PLGA RC MPs were found to cause a photoactivated cytotoxic effect for tumor cells and can be used for local application in PDT of tumors.

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“…Magnetic nanoparticles (MNPs) have been extensively used for various in vitro applications, and their unique abilities to respond to magnetic fields make them especially attractive for in vivo theranostics [ 1 , 2 , 3 , 4 , 5 , 6 ]. In vivo magnetofection, i.e., the delivery of genetic material with magnetic particles controlled by an external magnetic field, is a promising approach to significantly boost the efficiency of gene therapy.…”

Section: Introductionmentioning

confidence: 99%

Nonviral Locally Injected Magnetic Vectors for In Vivo Gene Delivery: A Review of Studies on Magnetofection

et al. 2021

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Magnetic nanoparticles have been widely used in nanobiomedicine for diagnostics and the treatment of diseases, and as carriers for various drugs. The unique magnetic properties of “magnetic” drugs allow their delivery in a targeted tumor or tissue upon application of a magnetic field. The approach of combining magnetic drug targeting and gene delivery is called magnetofection, and it is very promising. This method is simple and efficient for the delivery of genetic material to cells using magnetic nanoparticles controlled by an external magnetic field. However, magnetofection in vivo has been studied insufficiently both for local and systemic routes of magnetic vector injection, and the relevant data available in the literature are often merely descriptive and contradictory. In this review, we collected and systematized the data on the efficiency of the local injections of magnetic nanoparticles that carry genetic information upon application of external magnetic fields. We also investigated the efficiency of magnetofection in vivo, depending on the structure and coverage of magnetic vectors. The perspectives of the development of the method were also considered.

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Enhancement of the blood-circulation time and performance of nanomedicines via the forced clearance of erythrocytes

Cited by 116 publications

References 61 publications

NIR‐Actuated Remote Activation of Ferroptosis in Target Tumor Cells through a Photothermally Responsive Iron‐Chelated Biopolymer Nanoplatform

NIR‐Actuated Remote Activation of Ferroptosis in Target Tumor Cells through a Photothermally Responsive Iron‐Chelated Biopolymer Nanoplatform

Radachlorin-Containing Microparticles for Photodynamic Therapy

Nonviral Locally Injected Magnetic Vectors for In Vivo Gene Delivery: A Review of Studies on Magnetofection

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