Enhancement of the efficiency of photodynamic therapy of tumours by t-butyl-4-hydroxyanisole

Shevchuk, Igor; Chekulayev, Vladimir; Chekulayeva, L

doi:10.1016/s1011-1344(98)00172-9

Cited by 21 publications

(16 citation statements)

References 19 publications

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“…5-ALA-mediated PDT results in the formation of excessive amounts of ROS, which can significantly alter several crucial biomolecules, including DNA, proteins (enzyme inhibition), and lipids with undesirable consequences. The use of antioxidants during cancer therapy is currently a debated topic because of some contradicted findings [19][20][21]. Some data suggested that antioxidants can protect healthy cells and tissues from the damage of free radical without affecting treatment efficacy [22].…”

Section: Discussionmentioning

confidence: 99%

“…Frank et al [19] found that increasing intracellular concentrations of vitamin C contribute to the resistance of cultured cancer cells to pro-oxidant treatment modalities as 5-ALA-PDT. Shevchuk et al [20] found that t-butyl-4-hydroxyanisole (BHA) can enhance the efficiency of PDT. Kelley et al [21] demonstrated that loading the cells with antioxidants has no significant protection of Hypericin-photosensitized HL-60 cells.…”

Section: Discussionmentioning

confidence: 99%

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Antioxidant activity of mangostin in cell-free system and its effect on K562 leukemia cell line in photodynamic therapy

Zhang¹,

Wei²,

Yin³

2009

ABBS

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Mangostin (MAG), a kind of xanthone widely used in diet and medicine, has antioxidant, anti-inflammatory, antimicrobial, and anticancer activities. On account of its antioxidant activity, MAG might protect cancer cells from free radical damage in photodynamic therapy (PDT) during which reactive oxygen species production was stimulated leading to irreversible tumor cell injury. In this study, the antioxidant activity of MAG was investigated and the influence of MAG on K562 cells in 5-aminolevulinic acid (ALA)-based PDT is demonstrated. The results showed that MAG could scavenge hydroxyl radical, superoxide anion, and hydrogen peroxide and inhibit the formation of malondialdehyde (MDA), but increase the amounts of singlet oxygen in cell-free systems. MAG inhibits cell proliferation and enhances cell apoptosis, lipid peroxidation, and DNA damage in ALA-PDT on K562 cells. NaN 3 , a singlet oxygen quencher, suppresses the MAG-induced cell apoptosis, lipid peroxidation, and DNA damage. In conclusion, MAG enhances the PDT-induced cytotoxicity in K562 cells and singlet oxygen was involved in this process. These results implied that the effect of antioxidants on PDT might be determined by its sensitization ability to singlet oxygen.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Antioxidant activity of mangostin in cell-free system and its effect on K562 leukemia cell line in photodynamic therapy

Zhang¹,

Wei²,

Yin³

2009

ABBS

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“…Interestingly, some studies have shown the combinational use of certain antioxidants can also enhance the activity of PDT, in which process antioxidants exhibit pro-oxidant activities, especially in the presence of catalytic metals 103. Several research groups have reported results on the PDT enhancing activities of certain antioxidant molecules, such as ascorbate,104 3(2)-tetra-butyl-4-hydroxyanisole,105 epigallocatechin-3-gallate,106 α-tocopherol,107 and trolox ([±]-6-hydroxyl-2, 5, 7, 8-tetramethyl chromane-2-carboxylic acid, a water soluble vitamin E analogue) 108. Based on these intriguing results, some antioxidant carrier sensitizers (ACSs) which conjugated PSs and antioxidants together were designed and studied for their photodynamic anticancer109 and antibacterial activities 110.…”

Section: Pdtmentioning

confidence: 99%

Advance in Photosensitizers and Light Delivery for Photodynamic Therapy

2013

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The brief history of photodynamic therapy (PDT) research has been focused on photosensitizers (PSs) and light delivery was introduced recently. The appropriate PSs were developed from the first generation PS Photofrin (QLT) to the second (chlorins or bacteriochlorins derivatives) and third (conjugated PSs on carrier) generations PSs to overcome undesired disadvantages, and to increase selective tumor accumulation and excellent targeting. For the synthesis of new chlorin PSs chlorophyll a is isolated from natural plants or algae, and converted to methyl pheophorbide a (MPa) as an important starting material for further synthesis. MPa has various active functional groups easily modified for the preparation of different kinds of PSs, such as methyl pyropheophorbide a, purpurin-18, purpurinimide, and chlorin e6 derivatives. Combination therapy, such as chemotherapy and photothermal therapy with PDT, is shortly described here. Advanced light delivery system is shown to establish successful clinical applications of PDT. Phtodynamic efficiency of the PSs with light delivery was investigated in vitro and/or in vivo.

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“…Interestingly, some studies have shown the combinational use of certain antioxidants can also enhance activity of PDT, in which process antioxidants exhibit pro-oxidant activities, especially in the presence of catalytic metals. 197,198 Several research groups have reported results on the PDT enhancing activities of certain antioxidant molecules, such as ascorbate, 199 3(2)-tetra-butyl-4-hydroxyanisole (BHA), 200,201 epigallocatechin-3-gallate (EGCG), 202 α-tocopherol 203 and (±)-6-hydroxy-2,5,7,8-tetramethyl chromane-2-carboxylic acid (trolox, a water soluble vitamin E analog). 204 Reviews on this topic including different antioxidants have also been published by the authors (Jakus and Farkas,198 and Zuluaga and Lange 194 ).…”

Section: A Developmentmentioning

confidence: 99%

Ionic Liquid-Based Chlorins and Type III Mechanism of Photodynamic Therapy (PDT)

Yoon¹,

Demberelnyamba²,

Li³

et al. 2014

Handbook of Porphyrin Science

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Enhancement of the efficiency of photodynamic therapy of tumours by t-butyl-4-hydroxyanisole

Cited by 21 publications

References 19 publications

Antioxidant activity of mangostin in cell-free system and its effect on K562 leukemia cell line in photodynamic therapy

Antioxidant activity of mangostin in cell-free system and its effect on K562 leukemia cell line in photodynamic therapy

Advance in Photosensitizers and Light Delivery for Photodynamic Therapy

Ionic Liquid-Based Chlorins and Type III Mechanism of Photodynamic Therapy (PDT)

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