Enhancement of the functionality of women with knee osteoarthritis by a gel formulation with Caryocar coriaceum Wittm (“Pequi”) nanoencapsulated pulp fixed oil

Silva, Rodrigo de Faro; Barreto, André S.; Trindade, Gabriela das Graças Gomes; Lima, Cláudio Moreira; Araújo, Adriano Antunes de Souza; Menezes, Irwin Rose Alencar de; Cândido, Edna Aragão Farias; Santana, Érika Thatyana Nascimento; Silva-Júnior, Walderi Monteiro da; Quintans, Jullyana S.S.; Coutinho, Henrique Douglas Melo; Kim, Bonglee; Quintans‐Júnior, Lucindo J.

doi:10.1016/j.biopha.2022.112938

Cited by 9 publications

(5 citation statements)

References 53 publications

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“…Another molecule with high potential in the regulation of inflammation is the extract of Caryocar coriaceum Wittm fruits, as confirmed in a recent study [ 116 ].…”

Section: Fruit Componentsmentioning

confidence: 76%

Nutraceuticals: Focus on Anti-Inflammatory, Anti-Cancer, Antioxidant Properties in Gastrointestinal Tract

et al. 2022

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In recent years, nutraceuticals have gained great popularity, owing to their physiological and potential health effects, such as anti-inflammatory, anti-cancer, antioxidant, and prebiotic effects, and their regulation of lipid metabolism. Since the Mediterranean diet is a nutritionally recommended dietary pattern including high-level consumption of nutraceuticals, this review aimed to summarize the main results obtained by our in vitro and in vivo studies on the effects of the major constituents of the Mediterranean diet (i.e., extra virgin olive oil compounds, polyunsaturated fatty acids, and fruit components). Based on experimental studies, the therapeutic purpose of nutraceuticals depends on their bioavailability, solubility, toxicity, and delivery system. This review provides more in-depth knowledge on the effects linked to nutraceuticals administration on human health, focusing the gastrointestinal tract and suggesting specific dietary components for personalized adjuvant therapies.

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“…Another molecule with high potential in the regulation of inflammation is the extract of Caryocar coriaceum Wittm fruits, as confirmed in a recent study [ 116 ].…”

Section: Fruit Componentsmentioning

confidence: 76%

Nutraceuticals: Focus on Anti-Inflammatory, Anti-Cancer, Antioxidant Properties in Gastrointestinal Tract

et al. 2022

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“…This was demonstrated in the study by Ombredane (2020), where pequi oil-based nanoemulsions were developed and showed a greater antitumor effect against the breast cancer 4T1 cell line compared to free pequi oil [ 64 ]. Additionally, nanocapsules containing pequi oil ( Caryocar coriaceum ) incorporated into a gel were developed in the study by Silva (2022) and demonstrated significant efficacy in the treatment of osteoarthritis, alleviating symptoms in the knee [ 65 ].…”

Section: Resultsmentioning

confidence: 99%

Anti-Inflammatory Activity of Pequi Oil (Caryocar brasiliense): A Systematic Review

Silva,

Pinheiro,

Ombredane

et al. 2023

Pharmaceuticals

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Disorders in the inflammatory process underlie the pathogenesis of numerous diseases. The utilization of natural products as anti-inflammatory agents is a well-established approach in both traditional medicine and scientific research, with studies consistently demonstrating their efficacy in managing inflammatory conditions. Pequi oil, derived from Caryocar brasiliense, is a rich source of bioactive compounds including fatty acids and carotenoids, which exhibit immunomodulatory potential. This systematic review aims to comprehensively summarize the scientific evidence regarding the anti-inflammatory activity of pequi oil. Extensive literature searches were conducted across prominent databases (Scopus, BVS, CINAHL, Cochrane, LILACS, Embase, MEDLINE, ProQuest, PubMed, FSTA, ScienceDirect, and Web of Science). Studies evaluating the immunomodulatory activity of crude pequi oil using in vitro, in vivo models, or clinical trials were included. Out of the 438 articles identified, 10 met the stringent inclusion criteria. These studies collectively elucidate the potential of pequi oil to modulate gene expression, regulate circulating levels of pro- and anti-inflammatory mediators, and mitigate oxidative stress, immune cell migration, and cardinal signs of inflammation. Moreover, negligible to no toxicity of pequi oil was observed across the diverse evaluated models. Notably, variations in the chemical profile of the oil were noted, depending on the extraction methodology and geographical origin. This systematic review strongly supports the utility of pequi oil in controlling the inflammatory process. However, further comparative studies involving oils obtained via different methods and sourced from various regions are warranted to reinforce our understanding of its effectiveness and safety.

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“…Hydrogels possess a hydrophilic 3D network structure with a water content that can exceed 90% [ 56 , 57 ]. This characteristic facilitates the exchange of oxygen and substances [ 58 ], thereby promoting cell implantation, adhesion, and growth [ 59 ]. Due to their high biocompatibility, low immunogenicity, and tunable physicochemical properties [ 60 ], hydrogels have witnessed unprecedented development in the fields of tissue engineering [ 61 , 62 ].…”

Section: Bp-based Composite Biomaterials For Tissue Repairmentioning

confidence: 99%

Advances in the Application of Black Phosphorus-Based Composite Biomedical Materials in the Field of Tissue Engineering

Qi,

Zhang,

Wang

et al. 2024

Pharmaceuticals

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Black Phosphorus (BP) is a new semiconductor material with excellent biocompatibility, degradability, and optical and electrophysical properties. A growing number of studies show that BP has high potential applications in the biomedical field. This article aims to systematically review the research progress of BP composite medical materials in the field of tissue engineering, mining BP in bone regeneration, skin repair, nerve repair, inflammation, treatment methods, and the application mechanism. Furthermore, the paper discusses the shortcomings and future recommendations related to the development of BP. These shortcomings include stability, photothermal conversion capacity, preparation process, and other related issues. However, despite these challenges, the utilization of BP-based medical materials holds immense promise in revolutionizing the field of tissue repair.

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Enhancement of the functionality of women with knee osteoarthritis by a gel formulation with Caryocar coriaceum Wittm (“Pequi”) nanoencapsulated pulp fixed oil

Cited by 9 publications

References 53 publications

Nutraceuticals: Focus on Anti-Inflammatory, Anti-Cancer, Antioxidant Properties in Gastrointestinal Tract

Nutraceuticals: Focus on Anti-Inflammatory, Anti-Cancer, Antioxidant Properties in Gastrointestinal Tract

Anti-Inflammatory Activity of Pequi Oil (Caryocar brasiliense): A Systematic Review

Advances in the Application of Black Phosphorus-Based Composite Biomedical Materials in the Field of Tissue Engineering

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