Enhancement of the in vitro anticancer photo-sonodynamic combination therapy activity of cationic thiazole-phthalocyanines using gold and silver nanoparticles

Nene, Lindokuhle Cindy; Nyokong, Tebello

doi:10.1016/j.jphotochem.2022.114339

Cited by 13 publications

(13 citation statements)

References 46 publications

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“…114,115 The potential mechanisms of SDT on antibacterial performance include ROS generation and the mechanical stress induced by ultrasound. 116,117 Previous studies have indicated that the rapid rupture of bubbles during ultrasound exposure can result in a brief emission of light, known as sonoluminescence, which may trigger photochemical reactions in sonosensitizers similar to those observed in PDT, leading to the production of ROS. 118,119 Consequently, numerous photosensitizers exhibit promising potential as sonosensitizers.…”

Section: Sound-responsive Strategymentioning

confidence: 99%

“…The potential mechanisms of SDT on antibacterial performance include ROS generation and the mechanical stress induced by ultrasound. , Previous studies have indicated that the rapid rupture of bubbles during ultrasound exposure can result in a brief emission of light, known as sonoluminescence, which may trigger photochemical reactions in sonosensitizers similar to those observed in PDT, leading to the production of ROS. , Consequently, numerous photosensitizers exhibit promising potential as sonosensitizers. Additionally, cavitation, acoustic waves, and pyrolysis may also contribute to the mechanism of SDT. , The mechanical effects, primarily involving cavitation and acoustic wave effects, generate mechanical stress and facilitate ROS generation during SDT. , The ability of ultrasound to improve osteogenic capability depends on two main aspects: its own properties and its use to deliver osteogenesis-related drugs or factors.…”

Section: External Stimuli-responsive Strategies For Surface Modificat...mentioning

confidence: 99%

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External Stimuli-Responsive Strategies for Surface Modification of Orthopedic Implants: Killing Bacteria and Enhancing Osteogenesis

Liu,

Feng,

Ran

et al. 2024

ACS Appl. Mater. Interfaces

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Bacterial infection and insufficient osteogenic activity are the main causes of orthopedic implant failure. Conventional surface modification methods are difficult to meet the requirements for longterm implant placement. In order to better regulate the function of implant surfaces, especially to improve both the antibacterial and osteogenic activity, external stimuli-responsive (ESR) strategies have been employed for the surface modification of orthopedic implants. External stimuli act as "smart switches" to regulate the surface interactions with bacteria and cells. The balance between antibacterial and osteogenic capabilities of implant surfaces can be achieved through these specific ESR manifestations, including temperature changes, reactive oxygen species production, controlled release of bioactive molecules, controlled release of functional ions, etc. This Review summarizes the recent progress on different ESR strategies (based on light, ultrasound, electric, and magnetic fields) that can effectively balance antibacterial performance and osteogenic capability of orthopedic implants. Furthermore, the current limitations and challenges of ESR strategies for surface modification of orthopedic implants as well as future development direction are also discussed.

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Section: Sound-responsive Strategymentioning

confidence: 99%

Section: External Stimuli-responsive Strategies For Surface Modificat...mentioning

confidence: 99%

External Stimuli-Responsive Strategies for Surface Modification of Orthopedic Implants: Killing Bacteria and Enhancing Osteogenesis

Liu,

Feng,

Ran

et al. 2024

ACS Appl. Mater. Interfaces

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“…The conjugates generally performed better. 114 Pc 46 684 AgNPs 170 J/cm 2 , 10 min Pc 49 675 Pc-polymer SDT 1.0 MHz, 3.0 W/cm 2 , 5 min Breast (MCF-7) and mouse hepatoma (Hep 1-6 and H22) cells In vitro and in vivo The 1 O 2 yields and cytotoxicity efficacies increased for polymer Pc compared to the monomeric Pc. The polymer Pc showed enhanced cellular uptake.…”

Section: Molecular Design Considerations Of Pcs For Spdtmentioning

confidence: 99%

Design consideration of phthalocyanines as sensitizers for enhanced sono-photodynamic combinatorial therapy of cancer

Nene,

Abrahamse

2024

Acta Pharmaceutica Sinica B

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“…This combination method is a safe, nontoxic, and noninvasive way and enhances immune protective function and singlet oxygen generation. In experiments that involved comparative photochemical and sono-photochemical measurements, a noteworthy enhancement in the singlet oxygen quantum yield was noted when the sensitizer was activated through the sono-photochemical method. , Recently, with superior properties, Pcs have increased their use in SPDT applications. Pcs are widely recognized for their chemical and thermal stability. , They are conjugated and planar aromatic macrocycles consisting of four iminoisoindoline units .…”

Section: Introductionmentioning

confidence: 99%

Hybrid Sono-Photodynamic Combination Therapy Mediated by Water-Soluble Gallium Phthalocyanine Enhances the Cytotoxic Effect against Breast Cancer Cell Lines

Turkkol,

Can Karanlık,

Calıskan

et al. 2024

ACS Appl. Bio Mater.

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Breast cancer is a life-threatening disease that is gaining increasing importance due to its rising incidence, highlighting the need for novel treatment methods with the least disadvantages. Recently, scientists have focused on developing therapeutic treatment modalities for effective cancer treatment. In contrast to conventional cancer treatment methods such as immunotherapy, surgery, chemotherapy, or radiotherapy, photodynamic therapy (PDT) is gaining prominence. Besides, sonodynamic treatment (SDT) is a noninvasive therapeutic approach that uses ultrasound to induce high tissue penetration. In both methods, sensitizers are activated to generate cytotoxic reactive oxygen species such as •OH and 1O2. In particular, the combined use of hybrid and complementary treatment methods has become an important modality in cancer treatment in recent years. Sono-photodynamic therapy (SPDT), which is an important method applied in combination with PDT and SDT, has started to be preferred in terms of reducing potential side effects compared to monotherapy. One of the most important types of sensitizers used in PDT and SDT is known as phthalocyanines (Pcs). Motivated by these facts, this research presents the sono-photochemical, in vitro cytotoxicity, and theoretical evaluation of water-soluble gallium phthalocyanine (GaPc). The results indicate that the quantum yield of the generation of singlet oxygen increased in sono-photochemical studies (ΦΔ = 0.94), compared to photochemical studies (ΦΔ = 0.72). In vitro analyses revealed that GaPc did not exhibit significant cytotoxic effects at the specified varying concentration doses (1–20 μM). Furthermore, GaPc-mediated SPDT triggered cell death by inducing reactive oxygen species formation in the breast cancer cell line (MCF-7). The interaction mechanism of the GaPc with EGFR and VEGFR2 target proteins, which are critical regulators of metastasis, proliferation, and angiogenesis, was investigated by molecular docking simulation. GaPc has effective binding affinities against target proteins, and this affinity was found to be the highest against VEGFR2. Molecular docking results showed a good correlation with the obtained biological results. Eventually, this molecular building of the efficient water-soluble phthalocyanine-based sensitizer is a potential therapeutic for PDT, SDT, and SPDT applications.

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Enhancement of the in vitro anticancer photo-sonodynamic combination therapy activity of cationic thiazole-phthalocyanines using gold and silver nanoparticles

Cited by 13 publications

References 46 publications

External Stimuli-Responsive Strategies for Surface Modification of Orthopedic Implants: Killing Bacteria and Enhancing Osteogenesis

External Stimuli-Responsive Strategies for Surface Modification of Orthopedic Implants: Killing Bacteria and Enhancing Osteogenesis

Design consideration of phthalocyanines as sensitizers for enhanced sono-photodynamic combinatorial therapy of cancer

Hybrid Sono-Photodynamic Combination Therapy Mediated by Water-Soluble Gallium Phthalocyanine Enhances the Cytotoxic Effect against Breast Cancer Cell Lines

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