Enhancement of the Photolysis of Nucleic Acid Monomers by Phosphates

Abstract

Abstract— In the tentative simulation of prebiotic synthesis, it was found that the photolysis yield of nucleic acid bases, nucleosides and nucleotides (NA) undergoing UV irradiation was sharply enhanced by added orthophosphate. Filter experiments demonstrated that the enhancement is due to UV quanta of wavelength less than 215 nm in the emission spectrum of a medium pressure mercury lamp. The phosphate‐induced enhancement of the photolysis of NA constitutes an additional channel of nucleic acid monomer degradation through their interaction with photoionized phosphate radicals.

Photoinduced reduction of thymine and uracil derivatives by hypophosphite: unusual high quantum yield of chromophore loss

“…However, no significant f cl change for uracil and thymine has been observed in the presence of 0.1 m concentrations of other anions (SO 4 22 , Cl 2 , CO 3 22 , citrate, acetate, arsenate, cacodylate, orthophosphates, pyrophosphate), 0.1 m urea and 0.004 m metaphosphate under irradiation with 254 nm UV light. In contrast to the enhancement of the photolysis of nucleic acid monomers by orthophosphates and pyrophosphate, 4 no obvious f cl increase has been observed for cytosine, cytidine and cytidine-5A-monophosphate in the range 10 25 -1 m hypophosphite. For adenine, guanine and their derivatives, f cl was observed to increase when the concentration rises to more than 0.01 m, but the relative f cl value is < 5.…”

“…1,2 Here we report the photoinduced reduction (hydrogenation) of thymine (1a), uracil (1b) and their derivatives by hypophosphite, which was initially found in our tentative simulation of the photochemistry of the primitive sea, by irradiation with a medium pressure mercury lamp. 3 Contrary to the wavelength dependence of the enhancement of the photolysis of nucleic acid monomers by orthophosphates and pyrophosphate on UV light for photoionization of phosphates ( < 210 nm), 3,4 no obvious wavelength dependence has been observed in photoinduced reduction by hypophosphite. We present the results obtained by the irradiation with 254 nm UV light.…”

1,8‐Naphthalimide‐Based Chemosensors: A Promising Strategy for Detection of Metal Ions in Environmental and Biological Systems

“…Zinc (Zn 2+ ), the second‐most prevalent transition metal ion in the human body, is crucial for a variety of biological processes such as cellular growth, gene expression, enzymatic activity, cofactor, and disease control [155–159] . However, the inequitable distribution of metal ions in the body can cause various health problems such as diabetes, skin damage, neurological disorders, and immunological disorder [160–164] . The excessive level of zinc in plants and fresh water bodies has brought a paradigm shift in the toxicity level of the environment producing a catastrophic effect on mankind due to inevitable industrialization and modernization [165,166] .…”

Preparation and Specific Detection of Zn2+ Ions of Polyacylhydrazones with Polymerization‐Induced Emission

“…In recent years, fluorescence probes, especially small-molecular AIE-gens, have rapidly developed in the detection of heavy metal ions including Zn 2+ ions due to the advantages of fast response, simple operation, and high sensitivity. [25][26][27] The fundamentals of fluorescent detection are based on the interaction between probes and metal ions, through the change in the color, ultraviolet absorption, fluorescence, and other physical/chemical properties, to achieve the selective recognition of metal ions. [28][29][30] It should be noted that two facts cannot be ignored in the fluorescence detection of Zn 2+ ions.…”