Enhancement of transdermal absorption of drugs by pulsed output ultrasound: Effect of radiating area and frequency.

Asano, Junji; Ohe, Toshiharu; Kawasaki, Naoko; Miyazaki, Shôzo

doi:10.2745/dds.13.185

Cited by 1 publication

(1 citation statement)

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“…The limitation of the proposed method is that it requires an application time of one hour before an anesthetic effect occurs. Other possible methods for producing more immediate anesthetic effects include tape stripping to remove the stratum corneum for faster absorption of anesthetic ingredients [33], iontophoresis, which applies voltage to the body to cause chemical substances with an ionizing tendency to penetrate deep into the body [34], and pulsed ultrasound to subtly break the epidermis and promote transdermal absorption [35]. Our method is mainly focused on expanding the stimulation range of electrical stimulation and clarifying the stimulus.…”

Section: Discussionmentioning

confidence: 99%

Suppressing Discomfort Caused by Electrical Stimulation Using a Local Anesthetic Cream

et al. 2023

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Electrical stimulation is one of the methods that have been developed to stimulate skin sensations, and can provide sensations such as vibration and pressure by varying the polarity of the stimulus. Such stimuli can be combined to generate a variety of tactile sensations. However, itching or painful sensations are elicited with increasing amounts of electrical current. To address this major problem, in this study, we developed a method to suppress the itching and pain caused by electrical stimulation while presenting stable pressure and vibration sensations. We applied an anesthetic cream containing the commonly used local anesthetics lidocaine and propitocaine to reduce pain and itching associated with electrical stimulation. In particular, we examined the effects of the local anesthetic cream on pain and tactile thresholds. The results showed a significant relationship between the application of the cream and the dynamic range (i.e., pain and tactile thresholds) of the stimulating current. Thus, our proposed approach considerably improved the quality of the participants' subjective experience with electrical stimulation technology.

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Section: Discussionmentioning

confidence: 99%