Enhancement of transdermal protein delivery by photothermal effect of gold nanorods coated on polysaccharide-based hydrogel

Haine, Aung Thu; Koga, Yasutoshi; Hashimoto, Yuta; Higashi, Taishi; Motoyama, Keiichi; Arima, Hisatomi; Niidome, Takuro

doi:10.1016/j.ejpb.2017.06.005

Cited by 32 publications

(14 citation statements)

References 12 publications

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“…Most antigens delivered by nanocarriers are exogenous antigens, among which ovalbumin (OVA) is of the greatest interest due to its easy feasibility and proper immunogenicity. So polymeric nanoparticles, alginate nanoparticles, gold nanorods, mesoporous silica nanoparticles, lipid carriers, and clay nanoparticles have been designed to protect the antigens and sustainably release antigens as a “depot” and increase their processing and presentation . However, the development of tumor is always accompanied by mutations in a variety of proteins, which limits the outcome of a vaccine targeting just one mutant protein for tumor inhibition and elimination.…”

Section: Nanomaterials For Traditional and Novel Vaccine Deliverymentioning

confidence: 99%

Nanoparticle‐Based Nanomedicines to Promote Cancer Immunotherapy: Recent Advances and Future Directions

Liu

Zhang

2019

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Cancer immunotherapy is a promising cancer terminator by directing the patient's own immune system in the fight against this challenging disorder. Despite the monumental therapeutic potential of several immunotherapy strategies in clinical applications, the efficacious responses of a wide range of immunotherapeutic agents are limited in virtue of their inadequate accumulation in the tumor tissue and fatal side effects. In the last decades, increasing evidences disclose that nanotechnology acts as an appealing solution to address these technical barriers via conferring rational physicochemical properties to nanomaterials. In this Review, an imperative emphasis will be drawn from the current understanding of the effect of a nanosystem's structure characteristics (e.g., size, shape, surface charge, elasticity) and its chemical modification on its transport and biodistribution behavior. Subsequently, rapid‐moving advances of nanoparticle‐based cancer immunotherapies are summarized from traditional vaccine strategies to recent novel approaches, including delivery of immunotherapeutics (such as whole cancer cell vaccines, immune checkpoint blockade, and immunogenic cell death) and engineered immune cells, to regulate tumor microenvironment and activate cellular immunity. The future prospects may involve in the rational combination of a few immunotherapies for more efficient cancer inhibition and elimination.

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Section: Nanomaterials For Traditional and Novel Vaccine Deliverymentioning

confidence: 99%

Nanoparticle‐Based Nanomedicines to Promote Cancer Immunotherapy: Recent Advances and Future Directions

Liu

Zhang

2019

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124

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“…Over the past years, multiple external stimuli have been used for activating the release of a therapeutic agent from their carrier, namely mechanical stress, light, pH, heat, etc. 3 – 10 . However, the most attractive method for releasing active molecules is heating a thermoresponsive structure, since the heat will not only promote the release of drugs, but it could also enhance skin penetration by causing the pore dilation 11 , 12 .…”

Section: Introductionmentioning

confidence: 99%

Flexible Delivery Patch Systems based on Thermoresponsive Hydrogels and Submicronic Fiber Heaters

Evanghelidis

Beregoi

Diculescu

et al. 2018

Sci Rep

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This paper proposes a novel, flexible, low cost administration patch which could be used as a non-invasive, controlled transdermal drug delivery system. The fabricated device consists in a flexible microfiber architecture heater covered with a thermoresponsive hydrogel, namely poly(N-isopropylacrylamide), as a matrix for the incorporation of active molecules. The manufacturing process consists of two main steps. First, the electrospun poly(methyl methacrylate) fiber networks are sputter coated with a thin gold layer and attached to flexible poly(ethylene terephthalate) substrates to obtain the heating platforms. Second, the heaters are encapsulated in poly(ethylene terephthalate) foils and covered with poly(N-isopropylacrylamide) hydrogel sheets. In order to illustrate the functionality of the fabricated patch, the hydrogel layer is loaded with methylene blue aqueous solution and is afterwards heated via Joule effect, by applying a voltage on the metalized fibers. The methylene blue releasing profiles of the heated patch are compared with those of the unheated one and the influence of parameters such as hydrogel composition and morphology, as well as the applied voltage values for microheating are investigated. The results indicate that the fabricated patch can be used as a drug administration instrument, while its performance can be tuned depending on the targeted application.

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“…This is because thermotherapy can open blood vessels and increase blood flow, bringing nutrients for healing wounds, as demonstrated by a thermoelectric heat patch for clinical care based on Joule heating [55]. In addition, they can significantly accelerate the transdermal deliveries of medicines or cosmetic agents when put in contact with human skin by providing fluidity to the epidermis at an elevated temperature, thereby increasing mass transportation across the human skin [56][57][58]. Furthermore, photothermal heating materials such as gold nanorods were loaded in the stratum corneum of the skin and presented photothermally-driven antibacterial activity [59], and a thermoelectric heat patch based on Joule heating.…”

Section: Introductionmentioning

confidence: 99%

Functional Fibers, Composites and Textiles Utilizing Photothermal and Joule Heating

Park

2020

Polymers

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This review focuses on the mechanism of adjusting the thermal environment surrounding the human body via textiles. Recently highlighted technologies for thermal management are based on the photothermal conversion principle and Joule heating for wearable electronics. Recent innovations in this technology are described, with a focus on reports in the last three years and are categorized into three subjects: (1) thermal management technologies of a passive type using light irradiation of the outside environment (photothermal heating), (2) those of an active type employing external electrical circuits (Joule heating), and (3) biomimetic structures. Fibers and textiles from the design of fibers and textiles perspective are also discussed with suggestions for future directions to maximize thermal storage and to minimize heat loss.

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Enhancement of transdermal protein delivery by photothermal effect of gold nanorods coated on polysaccharide-based hydrogel

Cited by 32 publications

References 12 publications

Nanoparticle‐Based Nanomedicines to Promote Cancer Immunotherapy: Recent Advances and Future Directions

Nanoparticle‐Based Nanomedicines to Promote Cancer Immunotherapy: Recent Advances and Future Directions

Flexible Delivery Patch Systems based on Thermoresponsive Hydrogels and Submicronic Fiber Heaters

Functional Fibers, Composites and Textiles Utilizing Photothermal and Joule Heating

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