Enhancement of urate solubility by connective tissue

Perricone, Elaine; Brandt, Kenneth D.

doi:10.1002/art.1780210409

Cited by 22 publications

(2 citation statements)

References 18 publications

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“…Cartilage proteoglycan has been implicated in'urate nucleation by sudden release -of bound urate'6 but this binding now seems to ha an artefact of the prep technique. "7 18 In very concentrations, poisons mE prevent nucleation by bin( surfaces that would otherwise heterogeneous nucleation generally difficult to prove poison is binding to the unde small surface area of an u nucleating agent. Instead of bi the nucleating agent the pois bind to the surface of the crystal and slow or prevy addition of further mol Nancollas and Gardner have such an effect of pyrophosp oxalate crystal growth.…”

Section: Crystal Growthmentioning

confidence: 99%

Studies of urate crystallisation in relation to gout.

Fiddis¹,

Vlachos²,

Calvert³

1983

Annals of the Rheumatic Diseases

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Section: Crystal Growthmentioning

confidence: 99%

Studies of urate crystallisation in relation to gout.

Fiddis¹,

Vlachos²,

Calvert³

1983

Annals of the Rheumatic Diseases

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“…Addition of proteoglycans extracted from porcine cartilage to supersaturated solutions of sodium urate resulted in increased urate solubility. Similarly to the polysaccharides, only structurally intact, aggregated proteoglycans enhanced urate solubility; non-aggregated proteoglycans treated with enzyme did not change urate solubility [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

Factors influencing the crystallization of monosodium urate: a systematic literature review

Chhana

Lee

Dalbeth

2015

BMC Musculoskelet Disord

111

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BackgroundGout is a chronic disease of monosodium urate (MSU) crystal deposition. Although hyperuricaemia is the central risk factor for development of gout, not all people with hyperuricaemia have subclinical MSU crystal deposition or indeed, symptomatic disease. The aim of this systematic literature review was to identify factors that contribute to MSU crystallization.MethodsA search was conducted of the electronic databases PubMed, Science Direct and Scopus. Articles were included if they contained original data related to MSU crystallization. The methods and results were summarized and categorized into articles describing at least one of the three key steps in MSU crystallization (reduced urate solubility, nucleation and growth).ResultsA total of 2175 articles were initially identified in our systematic search with 35 of these articles included in the final analysis. Elevated urate concentration was identified as a central factor driving all three stages of MSU crystallization. Factors that were found to consistently reduce urate solubility were reduced temperatures, pH 7–9 and various ions including sodium ions. Connective tissue factors including bovine cartilage homogenates and healthy human synovial fluid and serum all enhanced urate solubility. MSU nucleation was found to be increased by a number of factors, including sodium ions, uric acid binding antibodies, and synovial fluid or serum from patients with gout. Other than elevated urate concentrations, no other specific factors were identified as promoters of MSU crystal growth.ConclusionsIncreased urate concentration is the key factor required at each stage of MSU crystallization. Different proteins and factors within connective tissues may promote MSU crystallization and may be important for determining the sites at which MSU crystallization occurs in the presence of elevated urate concentrations.Electronic supplementary materialThe online version of this article (doi:10.1186/s12891-015-0762-4) contains supplementary material, which is available to authorized users.

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Urate‐Mediated inflammation in nodal osteoarthritis: Clinical and roentgenographic correlations

Lally

Zimmermann

et al. 1989

Arthritis & Rheumatism

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We studied 25 patients with crystal-proven gout or roentgenographic evidence of gouty arthritis, or both, in finger joints involved with nodal osteoarthritis (OA). These patients were elderly (mean age 71.4 years), and 72% of them were receiving diuretic therapy. Roentgenographic findings, in addition to features typical of OA, included soft tissue densities (tophi), with or without calcification, large intraarticular erosions, characteristic nonmarginal cortical erosions, and periarticular osteolysis. We conclude that urate crystals mediate episodes of acute inflammation in certain patients with nodal OA. This association is noted primarily in elderly patients of both sexes, especially in those receiving diuretic therapy.

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Enhancement of urate solubility by connective tissue

Cited by 22 publications

References 18 publications

Studies of urate crystallisation in relation to gout.

Studies of urate crystallisation in relation to gout.

Factors influencing the crystallization of monosodium urate: a systematic literature review

Urate‐Mediated inflammation in nodal osteoarthritis: Clinical and roentgenographic correlations

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