Within the context of energy efficiency and environmental safety, the creation of energy and water supply systems integrated with the units for utilization of combustible waste, low-pressure gases and industrial wastewater are of high priority for oil and gas enterprises. A method for the synthesis of these rational systems and a two-dimensional model for evaluating performance indicators are proposed. We have developed alternative structures based on the block-modular principle of equipment composition formation, which allows structurally parametric integration of energy and utilization modules with technological productions; performed pre-project evaluation of the effectiveness of alternative options for the energy and water supply system with the utilization of low-pressure gases, thermal neutralization of industrial wastewater for methanol recovery plants and designed a multipurpose oil and gas condensate processing enterprise. Integration of utilization, energy and technological installations in energyand water supply systems allows reducing the consumption of heat and electric energy from external sources by 56–100%, and water consumption by 40–50%. Accordingly, the cost of wastewater reducing by an average of 76–93% for oil and gas condensate processing facilities. Almost complete utilization of low-pressure hydrocarbon gases is achieved (the volume of flared emissions is reduced by 90–98%).