Enhancement of wettability and antibiotic loading/release of hydroxyapatite thin film modified by 100MeV Ag7+ ion irradiation

Kolanthai, Elayaraja; Rajesh, P.; Joshy, M.I. Ahymah; Suganthi, R.V.; Kennedy, J.; Kulriya, P.K.; Sulania, Indra; Asokan, K.; Kanjilal, D.; Avasthi, D. K.; Varma, H. K.; Kalkura, S. Narayana

doi:10.1016/j.matchemphys.2012.03.018

Cited by 43 publications

(22 citation statements)

References 47 publications

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“…Inorganic Crystal Structure Database standards (ICSD-26204 for hydroxyapatite 40 and ICSD-158583 for magnetite 41 ). The peaks (see Figure 1A) at 2θ equal to 18.4°, 30.2°, 35.6°, 37.0, 43.1°, 53.4°, 57.2°, 62.7° has been ascribed to cubic inverse spinel structure, which crystallizes in orthorhombic Fd � 3m space group.…”

Section: Dovepressmentioning

confidence: 99%

Nanohydroxyapatite (nHAp) Doped with Iron Oxide Nanoparticles (IO), miR-21 and miR-124 Under Magnetic Field Conditions Modulates Osteoblast Viability, Reduces Inflammation and Inhibits the Growth of Osteoclast – A Novel Concept for Osteoporosis Treatment: Part 1

Marycz

Śmieszek

Marcinkowska

et al. 2021

IJN

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Purpose: Osteoporosis results in a severe decrease in the life quality of many people worldwide. The latest data shows that the number of osteoporotic fractures is becoming an increasing international health service problem. Therefore, a new kind of controllable treatment methods for osteoporotic fractures is extensively desired. For that reason, we have manufactured and evaluated nanohydroxyapatite (nHAp)-based composite co-doped with iron oxide (IO) nanoparticles. The biomaterial was used as a matrix for the controlled delivery of miR-21-5p and miR-124-3p, which have a proven impact on bone cell metabolism. Methods: The nanocomposite Ca 5 (PO 4 ) 3 OH/Fe 3 O 4 (later called nHAp/IO) was obtained by the wet chemistry method and functionalised with microRNAs (nHAp/IO@miR-21/124). Its physicochemical characterization was performed using XRPD, FT-IR, SEM-EDS and HRTEM and SAED methods. The modulatory effect of the composite was tested in vitro using murine pre-osteoblasts MC3T3-E1 and pre-osteoclasts 4B12. Moreover, the anti-inflammatory effects of biomaterial were analysed using a model of LPS-treated murine macrophages RAW 264.7. We have analysed the cells' viability, mitochondria membrane potential and oxidative stress under magnetic field (MF+) and without (MF-). Moreover, the results were supplemented with RT-qPCR and Western blot assays to evaluate the expression profile for master regulators of bone metabolism. Results: The results indicated pro-osteogenic effects of nHAp/IO@miR-21/124 composite enhanced by exposure to MF. The enhanced osteogenesis guided by nHAp/IO@miR-21/124 presence was associated with increased metabolism of progenitor cells and activation of osteogenic markers (Runx-2, Opn, Coll-1). Simultaneously, nanocomposite decreased metabolism and differentiation of pre-osteoclastic 4B12 cells accompanied by reduced expression of CaII and Ctsk. Obtained composite regulated viability of bone progenitor cells and showed immunomodulatory properties inhibiting the expression of inflammatory markers, ie, TNF-α, iNOs or IL-1β, in LPS-stimulated RAW 264.7 cells. Conclusion:We have described for the first time a new concept of osteoporosis treatment based on nHAp/IO@miR-21/124 application. Obtained results indicated that fabricated nanocomposite might impact proper regeneration of osteoporotic bone, restoring the balance between osteoblasts and osteoclast.

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Section: Dovepressmentioning

confidence: 99%

Nanohydroxyapatite (nHAp) Doped with Iron Oxide Nanoparticles (IO), miR-21 and miR-124 Under Magnetic Field Conditions Modulates Osteoblast Viability, Reduces Inflammation and Inhibits the Growth of Osteoclast – A Novel Concept for Osteoporosis Treatment: Part 1

Marycz

Śmieszek

Marcinkowska

et al. 2021

IJN

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“…Nano-hydroxyapatite [Ca 10 (PO 4 ) 6 (OH) 2 ] (n-HAP) is a very well-known inorganic material in the biological and medical fields [ 33 – 36 ], and can be used as an adsorbent for the removal of heavy metals and dyes, due to its low water solubility, high stability under reducing and oxidizing conditions, high specific surface area, and good buffering properties [ 37 , 38 ]. Application of hydroxyapatiteas drug carrier have been researched [ 39 – 42 ], Kumar synthesized HAP-ciprofloxacin powders by precipitation technique and investigated the adsorption and release process which may be an effective treatment of bacterial bone infections, and the adsorption was up to maximum in 24 hours while the release was slow and sustained for several weeks [ 41 ]; Yin et al studied the HAP adsorption of histatins 1,3 and 5 and concluded that histatin 5 could be impaired by mineral adsorption [ 42 ].…”

Section: Introductionmentioning

confidence: 99%

Adsorptive Removal and Adsorption Kinetics of Fluoroquinolone by Nano-Hydroxyapatite

et al. 2015

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Various kinds of antibiotics, especially fluoroquinolone antibiotics (FQs) have been widely used for the therapy of infectious diseases in human and livestock. For their poorly absorbed by living organisms, large-scale misuse or abuse of FQs will foster drug resistance among pathogenic bacteria, as well as a variety of environmental problems when they were released in the environment. In this work, the adsorption properties of two FQs, namely norfloxacin (NOR) and ciprofloxacin (CIP), by nano-hydroxyapatite (n-HAP) were studied by batch adsorption experiments. The adsorption curves of FQs by n-HAP were simulated by Langmuir and Freundlich isotherms. The results shown that NOR and CIP can be adsorbed effectively by the adsorbent of n-HAP, and the adsorption capacity of FQs increase with increasing dosage of n-HAP. The optimum dosage of n-HAP for FQs removal was 20 g·L-1, in which the removal efficiencies is 51.6% and 47.3%, and an adsorption equilibrium time is 20 min. The maximum removal efficiency occurred when pH is 6 for both FQs. The adsorption isotherm of FQs fits well for both Langmuir and Freundlich equations. The adsorption of both FQs by n-HAP follows second-order kinetics.

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“…The present study focuses on the removal Pb(II) from aqueous solution by hydroxyapatite (HA) [Ca 10 (PO 4 ) 6 (OH) 2 ]. HA is a major inorganic constituent of bone and teeth, which belongs to the family of apatite's (Elayaraja et al 2012). It is one such material with excellent biocompatibility, osteointegrity, and osseous inductivity (Gopi et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Adsorptive removal of Pb(II) from aqueous solution using nano-sized hydroxyapatite

et al. 2012

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This study investigated the sorption of Pb(II) in aqueous solution onto hydroxyapatite (HA) surfaces. Batch experiments were carried out using synthetic HA. The effect of contact time, HA dosage, and initial pH on removal efficiency were also investigated. The adsorption equilibrium and kinetics of Pb(II) on this adsorbent were then examined at 25°C. Kinetic data were analyzed by pseudo first, second, and intra-particle diffusion models. The sorption data were then correlated with the Langmuir, Freundlich, Halsey, and Harkins-Jura adsorption isotherm models. The optimum dose of HA for Pb(II) removal is found to be 0.12 g/l with the removal efficiency of 97.3 % at an equilibrium contact time of 1 h. It is found that the adsorption kinetics of the Pb(II) on HA follow the pseudo second-order reaction. All the isotherms fitted well for experimental data. Capacity of HA is found as 357.14 mg Pb(II)/g of HA. The Pb(II) immobilization mechanism was studied. The results indicated that HA can be used as an effective adsorbent for removal of Pb(II) from aqueous solution.

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Enhancement of wettability and antibiotic loading/release of hydroxyapatite thin film modified by 100MeV Ag7+ ion irradiation

Cited by 43 publications

References 47 publications

Nanohydroxyapatite (nHAp) Doped with Iron Oxide Nanoparticles (IO), miR-21 and miR-124 Under Magnetic Field Conditions Modulates Osteoblast Viability, Reduces Inflammation and Inhibits the Growth of Osteoclast – A Novel Concept for Osteoporosis Treatment: Part 1

Nanohydroxyapatite (nHAp) Doped with Iron Oxide Nanoparticles (IO), miR-21 and miR-124 Under Magnetic Field Conditions Modulates Osteoblast Viability, Reduces Inflammation and Inhibits the Growth of Osteoclast – A Novel Concept for Osteoporosis Treatment: Part 1

Adsorptive Removal and Adsorption Kinetics of Fluoroquinolone by Nano-Hydroxyapatite

Adsorptive removal of Pb(II) from aqueous solution using nano-sized hydroxyapatite

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