Enhancement radiation-induced apoptosis in C6 glioma tumor-bearing rats via pH-responsive magnetic graphene oxide nanocarrier

Shirvalilou, Sakine; Khoei, Samideh; Khoee, Sepideh; Mahdavi, Seied Rabi; Raoufi, Nida Jamali; Motevalian, Manijeh; Karimi, Mahdi

doi:10.1016/j.jphotobiol.2020.111827

Cited by 42 publications

(27 citation statements)

References 35 publications

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“…Nanomaterial-based drug delivery platforms have improved efficiency of targeted drug delivery approach through sustained delivery of therapeutics via nanomaterials without causing significant toxicity [ 132 , 133 ]. Understanding the genetic mechanisms underlying the spread of novel viral outbreaks has mostly been made possible through nanotechnology [ 134 ].…”

Section: Nanotechnology In Medicine; Nanomedicinementioning

confidence: 99%

Emerging importance of nanotechnology-based approaches to control the COVID-19 pandemic; focus on nanomedicine iterance in diagnosis and treatment of COVID-19 patients

Hashemi

Firouzi-Amandi

Amirazad

et al. 2022

Journal of Drug Delivery Science and Technology

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Section: Nanotechnology In Medicine; Nanomedicinementioning

confidence: 99%

Emerging importance of nanotechnology-based approaches to control the COVID-19 pandemic; focus on nanomedicine iterance in diagnosis and treatment of COVID-19 patients

Hashemi

Firouzi-Amandi

Amirazad

et al. 2022

Journal of Drug Delivery Science and Technology

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“…Compared with radiation alone, increasing the ratio of Bax/Bcl-2 (2.13 times) can significantly inhibit tumor expansion (>100%) and prolong survival time (>100%). Inhibit the anti-apoptotic response of glioma rats, thereby enhancing the sensitizing effect of tumor radiotherapy ( 27 ). Lei Chen et al.…”

Section: The Main Types Of Nano-radiosensitizers In the Treatment Of mentioning

confidence: 99%

“…and nephrotoxicity ( 26 ). 5-Iodine-2 deoxyuridine (IUdR) has been confirmed to have a significant radiosensitization effect on glioblastoma, but due to the short circulating half-life and the inability to pass the blood–brain barrier (BBB), its clinical application is limited ( 27 ). DNA double-strand repair inhibitors (DSBRIs) KU55933 were once considered as one of the most promising drugs to improve radiotherapy, but its clinical application remains due to its potential toxicity to normal tissues, inability to select-enter tumor cells, and poor solubilization ( 28 ).…”

Section: Introductionmentioning

confidence: 99%

Application of New Radiosensitizer Based on Nano-Biotechnology in the Treatment of Glioma

et al. 2021

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Glioma is the most common intracranial malignant tumor, and its specific pathogenesis has been unclear, which has always been an unresolved clinical problem due to the limited therapeutic window of glioma. As we all know, surgical resection, chemotherapy, and radiotherapy are the main treatment methods for glioma. With the development of clinical trials and traditional treatment techniques, radiotherapy for glioma has increasingly exposed defects in the treatment effect. In order to improve the bottleneck of radiotherapy for glioma, people have done a lot of work; among this, nano-radiosensitizers have offered a novel and potential treatment method. Compared with conventional radiotherapy, nanotechnology can overcome the blood–brain barrier and improve the sensitivity of glioma to radiotherapy. This paper focuses on the research progress of nano-radiosensitizers in radiotherapy for glioma.

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“…A large number of studies have been conducted on wide-ranged applications of nanomaterials (NMs), only to discover their peculiarly unfavorable effects. In terms of cell function and molecular pathway, NMs often cause profound adverse biological effects (Setyawati et al 2013a;Tay et al 2013;Afzalipour et al 2019;Shirvalilou et al 2020;Kondori et al 2020). Nanotechnology has multiple applications with a scientific impact; however, the underlying pathways in interaction of NMs with biological systems at a molecular level still remain to be elucidated.…”

Section: Nanotechnologymentioning

confidence: 99%

An Updated Review on Implications of Autophagy and Apoptosis in Tumorigenesis: Possible Alterations in Autophagy through Engineered Nanomaterials and Their Importance in Cancer Therapy

et al. 2021

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Most commonly recognized as a catabolic pathway, autophagy is a perplexing mechanism through which a living cell can free itself of excess cytoplasmic components, i.e., organelles, by means of certain membranous vesicles or lysosomes filled with degrading enzymes. Upon exposure to external insult or internal stimuli, the cell might opt to activate such pathway through which it can gain control over the maintenance of intracellular components, and thus, sustain homeostasis by intercepting the formation of unnecessary structures or elimination of the already present dysfunctional or inutile organelles. Despite such appropriateness, autophagy, might also be considered a frailty for the cell, as it has been said to have a rather complicated role in tumorigenesis. A merit in the early stages of tumor formation, autophagy appears to be salutary due to its tumor-suppressing effects. In fact, several investigations on tumorigenesis have reported diminished levels of autophagic activity in tumor cells, which might result in transition to malignancy. On the contrary, autophagy has been suggested to be a seemingly favorable mechanism to progressed malignancies, as it contributes to survival of such cells. Based on the recent literature, this mechanism might also be activated upon the entry of engineered nanomaterials inside a cell, supposedly protecting the host from foreign materials. Accordingly, there is a good chance that therapeutic interventions for modulating autophagy in malignant cells using nanoparticles may sensitize cancerous cells to certain treatment modalities, e.g., radiotherapy. In this review, we will discuss the signaling pathways involved in autophagy, and the significance of the mechanism itself in apoptosis and tumorigenesis, while shedding light on possible alterations in autophagy through engineered nanomaterials, and the their potential therapeutic applications in cancer.

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Enhancement radiation-induced apoptosis in C6 glioma tumor-bearing rats via pH-responsive magnetic graphene oxide nanocarrier

Cited by 42 publications

References 35 publications

Emerging importance of nanotechnology-based approaches to control the COVID-19 pandemic; focus on nanomedicine iterance in diagnosis and treatment of COVID-19 patients

Emerging importance of nanotechnology-based approaches to control the COVID-19 pandemic; focus on nanomedicine iterance in diagnosis and treatment of COVID-19 patients

Application of New Radiosensitizer Based on Nano-Biotechnology in the Treatment of Glioma

An Updated Review on Implications of Autophagy and Apoptosis in Tumorigenesis: Possible Alterations in Autophagy through Engineered Nanomaterials and Their Importance in Cancer Therapy

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