Enhancing 5-ALA-PDT efficacy against resistant tumor cells: Strategies and advances

Ebrahimi, Safieh; Khaleghi Ghadiri, Maryam; Stummer, Walter; Gorji, Ali

doi:10.1016/j.lfs.2024.122808

Life Sciences

2024

DOI: 10.1016/j.lfs.2024.122808

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Enhancing 5-ALA-PDT efficacy against resistant tumor cells: Strategies and advances

Safieh Ebrahimi,

Maryam Khaleghi Ghadiri,

Walter Stummer

et al.

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2024

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Cited by 3 publications

References 183 publications

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Effects of aminolevulinic acid photodynamic therapy combined with antibiotics on Mycobacterium abscessus skin infections: An in vitro and in vivo study

Wang,

Kou

et al. 2024

Photodiagnosis and Photodynamic Therapy

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Effects of aminolevulinic acid photodynamic therapy combined with antibiotics on Mycobacterium abscessus skin infections: An in vitro and in vivo study

Wang,

Kou

et al. 2024

Photodiagnosis and Photodynamic Therapy

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Thou shalt not pass - arachnid venom peptides interacting with biological membranes

Wang,

Guo,

Jee

et al. 2024

Front. Arachn. Sci.

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Arachnid venom peptides receive increasing attention from researchers for possible applications as human therapeutics, as bioinsecticides in agriculture or for targeting vectors of human disease. One commonly perceived disadvantage of peptides in contrast to small molecule drugs is their inability of crossing biological membranes comprised of lipid bilayers, providing a major obstacle for the delivery of peptide-based drugs and bioinsecticides. However, some arachnid venom peptides were reported to cross biological membranes, including cellular membranes, the vertebrate and insect blood brain barrier (BBB) and the insect midgut epithelium. This review will focus on these membrane-permeating arachnid peptides and discuss the underlying mechanisms. Different physico-chemical properties of membrane-permeating arachnid peptides and their contribution to the ability of crossing biological membranes will also be examined. In addition, several methods that facilitate or enable peptides to cross biological membranes will be discussed, which can be employed on peptides with no inherent membrane-permeating capabilities.

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Uncovering Porphyrin Accumulation in the Tumor Microenvironment

Adapa,

Sami,

Meshram

et al. 2024

Genes

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Heme, an iron-containing tetrapyrrole, is essential in almost all organisms. Heme biosynthesis needs to be precisely regulated particularly given the potential cytotoxicity of protoporphyrin IX, the intermediate preceding heme formation. Here, we report on the porphyrin intermediate accumulation within the tumor microenvironment (TME), which we propose to result from dysregulation of heme biosynthesis concomitant with an enhanced cancer survival dependence on mid-step genes, a process we recently termed “Porphyrin Overdrive”. Specifically, porphyrins build up in both lung cancer cells and stromal cells in the TME. Within the TME’s stromal cells, evidence supports cancer-associated fibroblasts (CAFs) actively producing porphyrins through an imbalanced pathway. Conversely, normal tissues exhibit no porphyrin accumulation, and CAFs deprived of tumor cease porphyrin overproduction, indicating that both cancer and tumor-stromal porphyrin overproduction is confined to the cancer-specific tissue niche. The clinical relevance of our findings is implied by establishing a correlation between imbalanced porphyrin production and overall poorer survival in more aggressive cancers. These findings illuminate the anomalous porphyrin dynamics specifically within the tumor microenvironment, suggesting a potential target for therapeutic intervention.

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Enhancing 5-ALA-PDT efficacy against resistant tumor cells: Strategies and advances

Cited by 3 publications

References 183 publications

Effects of aminolevulinic acid photodynamic therapy combined with antibiotics on Mycobacterium abscessus skin infections: An in vitro and in vivo study

Effects of aminolevulinic acid photodynamic therapy combined with antibiotics on Mycobacterium abscessus skin infections: An in vitro and in vivo study

Thou shalt not pass - arachnid venom peptides interacting with biological membranes

Uncovering Porphyrin Accumulation in the Tumor Microenvironment

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