Purpose:
The current study explored physical activity-induced bone adaptation at different stages of somatic maturity by comparing side-to-side differences in midshaft humerus properties between male throwing athletes and controls. Throwers present an internally controlled model, while inclusion of control subjects removes normal arm dominance influences.
Methods:
Throwing athletes (n=90) and controls (n=51) were categorized into maturity groups (PRE, PERI, POST-EARLY, POST-MID and POST-LATE) based on estimated years from peak height velocity (<−2, −2-to-2, 2-to-4, 4-to-10 and >10 years). Side-to-side percent differences in midshaft humerus cortical volumetric bone mineral density (Ct.vBMD) and bone mineral content (Ct.BMC), total (Tt.Ar), medullary (Me.Ar) and cortical (Ct.Ar) area, average cortical thickness (Ct.Th), and polar Strength Strain Index (SSIP) was assessed.
Results:
Significant interactions between physical activity and maturity on side-to-side differences in Ct.BMC, Tt.Ar, Ct.Ar, Me.Ar, Ct.Th and SSIP resulted from: 1) greater throwing-to-nonthrowing arm differences than dominant-to-nondominant arm differences in controls (all p<0.05), and; 2) throwing-to-nonthrowing arm differences in throwers being progressively greater across maturity groups (all p<0.05). Regional analyses revealed greatest adaptation in medial and lateral sectors, particularly in the three POST maturity groups. Years throwing predicted 59% of the variance of the variance in throwing-to-nonthrowing arm difference in SSIP (p<0.001).
Conclusion:
These data suggest physical activity has skeletal benefits beginning prior to and continuing beyond somatic maturation, and that a longer duration of exposure to physical activity has cumulative skeletal benefits. Thus, physical activity should be encouraged at the earliest age possible and be continued into early adulthood to optimize skeletal benefits.