Enhancing ACE-inhibition of food protein hydrolysates by selective adsorption using porous carbon materials

Hippauf, Felix; Lunow, Diana; Huettner, Christiane; Nickel, Winfried; Borchardt, Lars; Henle, Thomas; Kaskel, Stefan

doi:10.1016/j.carbon.2015.02.023

Cited by 13 publications

(21 citation statements)

References 30 publications

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“…The column bed was replaced after the cycling tests to start with a fresh stationary phase. An a-lactalbumin hydrolysate (AAT) solution containing 0.05 mM Ile-Trp was used as the mobile phase, which is comparable to previous batch experiments [26]. According to the Ile-Trp isotherm, the carbon is not completely saturated at this concentration.…”

Section: Ace-inhibitor Enrichment From Protein Hydrolysatesmentioning

confidence: 58%

“…S8). As reported before, a polarity and size selective adsorption is essential for a successful Ile-Trp purification [26].…”

Section: Ace-inhibitor Enrichment From Protein Hydrolysatesmentioning

confidence: 79%

“…Batch enrichment was carried out in analogy to our previous publication [26]. An AAT solution (50 ml, 6.4 g AAT l À1 ) was thoroughly mixed with 50 mg of F50 and stirred for 1 h at room temperature.…”

Section: Separation and Quantification Of Tryptophan-containing Peptimentioning

confidence: 99%

“…More polar and longer peptides have less attractive pore wall interactions leading to a selective adsorption of Ile-Trp and other Trp-containing peptides from several food protein hydrolysates. Subsequent elution from the adsorbent using ethanol/water mixtures leads to an up to 11 times higher Ile-Trp concentration in the eluate [26]. Consequently, the ACE-inhibition of the eluate is increased significantly.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Towards a continuous adsorption process for the enrichment of ACE-inhibiting peptides from food protein hydrolysates

Hippauf

Huettner

Lunow

et al. 2016

Carbon

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Section: Ace-inhibitor Enrichment From Protein Hydrolysatesmentioning

confidence: 58%

“…S8). As reported before, a polarity and size selective adsorption is essential for a successful Ile-Trp purification [26].…”

Section: Ace-inhibitor Enrichment From Protein Hydrolysatesmentioning

confidence: 79%

Section: Separation and Quantification Of Tryptophan-containing Peptimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Towards a continuous adsorption process for the enrichment of ACE-inhibiting peptides from food protein hydrolysates

Hippauf

Huettner

Lunow

et al. 2016

Carbon

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“…These micropores are usually introduced by physical or chemical activation, often leading to broad pore-size distributions and non-uniform pore structures [ 11 ]. However, for size-selective applications [ 12 ], non-uniform broad pore-size distributions lead to lower performance metrics [ 13 – 14 ]; they are also detrimental to derive clear statements about structure–performance relationships for fundamental research, such as the influence of the pore size and the pore structure on (electro)sorption in energy storage devices [ 15 – 17 ]. Moreover, purely microporous carbons suffer from diffusion limitations resulting in low electrochemical performances at high charge/discharge rates [ 4 , 18 – 19 ].…”

Section: Introductionmentioning

confidence: 99%

Mechanochemistry-assisted synthesis of hierarchical porous carbons applied as supercapacitors

Leistenschneider

Jäckel

Hippauf

et al. 2017

Beilstein J. Org. Chem.

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A solvent-free synthesis of hierarchical porous carbons is conducted by a facile and fast mechanochemical reaction in a ball mill. By means of a mechanochemical ball-milling approach, we obtained titanium(IV) citrate-based polymers, which have been processed via high temperature chlorine treatment to hierarchical porous carbons with a high specific surface area of up to 1814 m2 g−1 and well-defined pore structures. The carbons are applied as electrode materials in electric double-layer capacitors showing high specific capacitances with 98 F g−1 in organic and 138 F g−1 in an ionic liquid electrolyte as well as good rate capabilities, maintaining 87% of the initial capacitance with 1 M TEA-BF4 in acetonitrile (ACN) and 81% at 10 A g−1 in EMIM-BF4.

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The Importance of Pore Size and Surface Polarity for Polysulfide Adsorption in Lithium Sulfur Batteries

Hippauf

Nickel

Hao

et al. 2016

Adv Materials Inter

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Polysulfide shuttling is a crucial factor in lithium sulfur batteries responsible for capacity fading and degradation. Liquid phase adsorption in combination with nuclear magnetic resonance and X‐ray photoelectron spectroscopy are used to elucidate and quantify polysulfide retention in typical porous cathode materials used in lithium sulfur batteries without cell assembly to achieve a more fundamental understanding of liquid phase adsorption phenomena as a responsible mechanism for polysulfide retention. The individual impact of each pore size increment is quantified on the polysulfide adsorption (PSA). Ultramicropores show eight times higher PSA (1.48 mmol cm−3) than mesopores. Strong heteroatom‐doped ultramicropores show even stronger interactions with polysulfides leading to 25 times higher adsorption compared to hydrophobic mesopores. These findings allow to precisely tailor pore structure and heteroatom distribution of cathode materials for next generation lithium sulfur batteries with prolonged cycle life and reduced capacity fading.

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Enhancing ACE-inhibition of food protein hydrolysates by selective adsorption using porous carbon materials

Cited by 13 publications

References 30 publications

Towards a continuous adsorption process for the enrichment of ACE-inhibiting peptides from food protein hydrolysates

Towards a continuous adsorption process for the enrichment of ACE-inhibiting peptides from food protein hydrolysates

Mechanochemistry-assisted synthesis of hierarchical porous carbons applied as supercapacitors

The Importance of Pore Size and Surface Polarity for Polysulfide Adsorption in Lithium Sulfur Batteries

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