Enhancing biocompatibility of polyaniline-based scaffolds by using a bioactive dopant

Daraeinejad, Zohreh; Shabani, Iman

doi:10.1016/j.synthmet.2020.116642

Cited by 19 publications

(11 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is worth noting that PAni exhibits the emeraldine oxidation state because the intensity is higher in the benzenoid ring than in the quinoid ring [ 43 ]. The spectrum also shows a band at 1288 cm −1 assigned to the bond C-N formed through oxidative polymerization [ 44 ].…”

Section: Resultsmentioning

confidence: 99%

Brush-like Polyaniline with Optical and Electroactive Properties at Neutral pH and High Temperature

Conejo-Dávila

Casas-Soto

Aparicio-Martínez

et al. 2022

IJMS

View full text Add to dashboard Cite

In this research, a brush-like polyaniline (poly(2-acrylamide-2-methyl-1-propanesulfonate)-g-polyaniline)-b-poly(N-vinylcarbazole) (BL PAni) was developed as a strategy to overcome the limited processability and dedoping above pH 4 of conventional polyaniline (PAni). For the BL PAni synthesis, RAFT polymerization (homopolymer), RAFT-mediated surfactant-free emulsion polymerization (block copolymer), and interfacial oxidative polymerization were applied to graft the PAni chains. NMR and FT-IR spectroscopies were performed to confirm the structural elucidation of the reaction pathways, while the thermal properties were analyzed by TGA and DSC. Notably, the BL PAni presents absorption throughout the visible region and up to the near-infrared, showing dedoping resistance at up to 80 °C and at a neutral pH. The absorption range of the BL PAni, block copolymer, and homopolymer were studied by UV–Vis spectroscopy in solid-state and dispersion/solution, highlighting BL PAni and poly(anilinium 2-acrylamide-2-methyl-1-propanesulfonate)-b-poly(N-vinylcarbazole) (PAAMP-b-PVK) due to the π-stacking between the anilinium and carbazole groups. The cyclic voltammetry confirmed the persistence of electroactivity at a pH near 7.

show abstract

Section: Resultsmentioning

confidence: 99%

Brush-like Polyaniline with Optical and Electroactive Properties at Neutral pH and High Temperature

Conejo-Dávila

Casas-Soto

Aparicio-Martínez

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…It was demonstrated that the biochemical properties of PANI largely depend on the dopant used for it. The cytotoxicity of PANI-based nanofibers was significantly reduced by replacing CSA with taurine as a bioactive dopant ( Daraeinejad and Shabani, 2021 ). 3D scaffold had higher percentage of PANI than 2D scaffolds.…”

Section: Discussionmentioning

confidence: 99%

Enhancing Cellular Infiltration on Fluffy Polyaniline-Based Electrospun Nanofibers

Daraeinejad

Shabani

2021

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…During the printing process, the solvent is dried resulting in fiber meshes composed of strains of diameter in the nanoscale. Fiber meshes made from CPs such as PEDOT, ,, PANI, ,,− and PPy, among others, have been successfully realized via electrospinning. Some of them have been mixed with biopolymers to increase their biocompatibility and improve mechanical properties. ,, Mixtures of PANI with polycaprolactone have been extensively used in electrospinning for vasculature, neural, ,, and osteogenic differentiation. , Stevens and co-workers developed electrospun block copolymers of aniline tetramer and PCL named AT-PCL.…”

Section: Interfacing Organic Bioelectronics With Cellsmentioning

confidence: 99%

Organic Bioelectronics for In Vitro Systems

et al. 2021

View full text Add to dashboard Cite

Bioelectronics have made strides in improving clinical diagnostics and precision medicine. The potential of bioelectronics for bidirectional interfacing with biology through continuous, label-free monitoring on one side and precise control of biological activity on the other has extended their application scope to in vitro systems. The advent of microfluidics and the considerable advances in reliability and complexity of in vitro models promise to eventually significantly reduce or replace animal studies, currently the gold standard in drug discovery and toxicology testing. Bioelectronics are anticipated to play a major role in this transition offering a much needed technology to push forward the drug discovery paradigm. Organic electronic materials, notably conjugated polymers, having demonstrated technological maturity in fields such as solar cells and light emitting diodes given their outstanding characteristics and versatility in processing, are the obvious route forward for bioelectronics due to their biomimetic nature, among other merits. This review highlights the advances in conjugated polymers for interfacing with biological tissue in vitro, aiming ultimately to develop next generation in vitro systems. We showcase in vitro interfacing across multiple length scales, involving biological models of varying complexity, from cell components to complex 3D cell cultures. The state of the art, the possibilities, and the challenges of conjugated polymers toward clinical translation of in vitro systems are also discussed throughout.

show abstract

Enhancing biocompatibility of polyaniline-based scaffolds by using a bioactive dopant

Cited by 19 publications

References 40 publications

Brush-like Polyaniline with Optical and Electroactive Properties at Neutral pH and High Temperature

Brush-like Polyaniline with Optical and Electroactive Properties at Neutral pH and High Temperature

Enhancing Cellular Infiltration on Fluffy Polyaniline-Based Electrospun Nanofibers

Organic Bioelectronics for In Vitro Systems

Contact Info

Product

Resources

About