Enhancing cross‐scale Raman in‐line monitoring capability of cell culture process in large‐scale manufacturing
Zhe Lang,
Gong Chen,
Shaofan Yan
et al.
Abstract:This study introduces an approach to enhance the Raman calibration model cross‐scale prediction capabilities in cell cultures. Our investigation centers on the improvement of Raman calibration models along with the scaling‐up of mammalian cell culture processes. Initially, we observed that integrating data from a 50 L run into the original dataset at lab‐scale was an effective strategy for improving prediction accuracy on 1000 L run. Further investigation indicated that this improvement could be attributed to … Show more
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