Enhancing curcumin's solubility and antibiofilm activity<i>via</i>silica surface modification

Barros, Caio; Devlin, Henry B.; Hiebner, Dishon; Vitale, Stefania; Quinn, Laura; Casey, Eoin

doi:10.1039/d0na00041h

Cited by 29 publications

(25 citation statements)

References 85 publications

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“…Interestingly, free curcumin at equivalent concentrations was not able to inhibit bacterial growth to any extent. This fact is in line with what was already observed by our research group with the functionalisation of curcumin onto silica NPs [ 40 ]. This result suggests that the conjugation of curcumin on the micelle structure might have improved the natural product’s solubility and transport in the bacterial suspension, which in turn accentuated its antimicrobial capacity.…”

Section: Resultssupporting

confidence: 93%

“…Still, curcumin incorporated in micelles performs better than when administered freely at the same equivalent concentration. This effect could be due to an increase in the local concentration of curcumin combined with better transport to the biofilm’s innermost regions, which was already performed by our group previously [ 40 ]. Additionally, both curcumin and PLGA-Dex 10 -curc seem to also interfere with biofilm biomass formation.…”

Section: Resultsmentioning

confidence: 76%

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Synthesis and self-assembly of curcumin-modified amphiphilic polymeric micelles with antibacterial activity

et al. 2021

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Background The ubiquitous nature of bacterial biofilms combined with the enhanced resistance towards antimicrobials has led to the development of an increasing number of strategies for biofilm eradication. Such strategies must take into account the existence of extracellular polymeric substances, which obstruct the diffusion of antibiofilm agents and assists in the maintenance of a well-defended microbial community. Within this context, nanoparticles have been studied for their drug delivery efficacy and easily customised surface. Nevertheless, there usually is a requirement for nanocarriers to be used in association with an antimicrobial agent; the intrinsically antimicrobial nanoparticles are most often made of metals or metal oxides, which is not ideal from ecological and biomedical perspectives. Based on this, the use of polymeric micelles as nanocarriers is appealing as they can be easily prepared using biodegradable organic materials. Results In the present work, micelles comprised of poly(lactic-co-glycolic acid) and dextran are prepared and then functionalised with curcumin. The effect of the functionalisation in the micelle’s physical properties was elucidated, and the antibacterial and antibiofilm activities were assessed for the prepared polymeric nanoparticles against Pseudomonas spp. cells and biofilms. It was found that the nanoparticles have good penetration into the biofilms, which resulted in enhanced antibacterial activity of the conjugated micelles when compared to free curcumin. Furthermore, the curcumin-functionalised micelles were efficient at disrupting mature biofilms and demonstrated antibacterial activity towards biofilm-embedded cells. Conclusion Curcumin-functionalised poly(lactic-co-glycolic acid)-dextran micelles are novel nanostructures with an intrinsic antibacterial activity tested against two Pseudomonas spp. strains that have the potential to be further exploited to deliver a secondary bioactive molecule within its core. Graphic Abstract

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Section: Resultssupporting

confidence: 93%

Section: Resultsmentioning

confidence: 76%

Synthesis and self-assembly of curcumin-modified amphiphilic polymeric micelles with antibacterial activity

et al. 2021

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“…The antibiofilm activity of the samples was assayed following the approach described by Barros et al [44] with our modification. The film sections (1.5 cm × 1.5 cm) were applied to a 12-well cell culture plate and then each was flooded with 4 mL of Tryptic Soy Broth.…”

Section: Determination Of Biofilm Formation On Filmsmentioning

confidence: 99%

Antimicrobial, Antibiofilm, and Antioxidant Activity of Functional Poly(Butylene Succinate) Films Modified with Curcumin and Carvacrol

et al. 2021

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The use of food industry waste as bioactive compounds in the modification of biodegradable films as food packaging remains a major challenge. This study describes the preparation and bioactivity characterization of poly(butylene succinate) (PBS)-based films with the addition of the bioactive compounds curcumin (CUR) and carvacrol (CAR). Films based on PBS modified with curcumin and carvacrol at different concentration variations (0%/0.1%/1%) were prepared by solvent casting method. The antioxidant, antimicrobial, and antibiofilm properties were investigated against bacteria (Escherichia coli, Staphylococcus aureus) and fungi (Candida albicans). As a result of the modification, the films exhibited free radicals scavenging (DPPH up to 91.47% and ABTS up to 99.21%), as well as antimicrobial (6 log, 4 log, and 2 log reductions for E. coli, S. aureus, and C. albicans, respectively, for samples modified with 1% CUR and 1% CAR) activity. Moreover, antibiofilm activity of modified materials was observed (8.22–87.91% reduction of biofilm, depending on bioactive compounds concentration). PBS films modified with curcumin and carvacrol with observed bifunctional properties have many potential applications as active packaging.

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“…Moreover, the antimicrobial properties of curcumin have led to the development of composite materials compatible with the molecular structure of the dye used in order to obtain coatings with antibiofilm properties [ 39 , 40 ]. For this purpose, several types of materials were made and in order to do that curcumin was encapsulated in various polymeric matrices, such as cellulose [ 41 , 42 ], polyvinyl derivatives [ 43 ], or siloxanes [ 44 , 45 ]. Each of them has specific characteristics depending on the purpose of use: food packaging [ 46 , 47 , 48 , 49 ], coatings of equipment in the food industry, medical devices, surfaces, and utensils for medical use [ 50 ].…”

Section: Introductionmentioning

confidence: 99%

Modeling the Properties of Curcumin Derivatives in Relation to the Architecture of the Siloxane Host Matrices

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Rădiţoiu

et al. 2021

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Research in the field of natural dyes has constantly focused on methods of conditioning curcumin and diversifying their fields of use. In this study, hybrid materials were obtained from modified silica structures, as host matrices, in which curcumin dyes were embedded. The influence of the silica network structure on the optical properties and the antimicrobial activity of the hybrid materials was monitored. By modifying the ratio between phenyltriethoxysilane:diphenyldimethoxysilane (PTES:DPDMES), it was possible to evaluate the influence the organosilane network modifiers had on the morphostructural characteristics of nanocomposites. The nanosols were obtained by the sol–gel method, in acid catalysis. The nanocomposites obtained were deposited as films on a glass support and showed a transmittance value (T measured at 550 nm) of around 90% and reflectance of about 11%, comparable to the properties of the uncovered support. For the coatings deposited on PET (polyethylene terephthalate) films, these properties remained at average values of T550 = 85% and R550 = 11% without significantly modifying the optical properties of the support. The sequestration of the dye in silica networks reduced the antimicrobial activity of the nanocomposites obtained, by comparison to native dyes. Tests performed on Candida albicans fungi showed good results for the two curcumin derivatives embedded in silica networks (11–18 mm) by using the spot inoculation method; in comparison, the alcoholic dye solution has a spot diameter of 20–23 mm. In addition, hybrids with the CA derivative were the most effective (halo diameter of 17–18 mm) in inhibiting the growth of Gram-positive bacteria, compared to the curcumin derivative in alcoholic solution (halo diameter of 21 mm). The results of the study showed that the presence of 20–40% by weight DPDMES in the composition of nanosols is the optimal range for obtaining hybrid films that host curcumin derivatives, with potential uses in the field of optical films or bioactive coatings.

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Enhancing curcumin's solubility and antibiofilm activityviasilica surface modification

Abstract: Conjugation of curcumin to silica nanoparticles increases the bioavailability of the natural compound and enhances its antibiofilm activity.

Cited by 29 publications

References 85 publications

Synthesis and self-assembly of curcumin-modified amphiphilic polymeric micelles with antibacterial activity

Synthesis and self-assembly of curcumin-modified amphiphilic polymeric micelles with antibacterial activity

Antimicrobial, Antibiofilm, and Antioxidant Activity of Functional Poly(Butylene Succinate) Films Modified with Curcumin and Carvacrol

Modeling the Properties of Curcumin Derivatives in Relation to the Architecture of the Siloxane Host Matrices

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