Enhancing Effect of Antilymphocytic Globulin on Human Leprosy Infection in Thymectomized Mice

Gaugas, J. M.

doi:10.1038/2201246a0

Cited by 28 publications

(14 citation statements)

References 10 publications

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“…In order that growth of surviving organisms may be detected, the total number of bacilli which can be investigated after drug action is lo5 per footpad or fewer. This allows a 10-fold thymocyte globulin ( 16), or by antithymocyte globulin and steroids (8) may provide conditions in which considerably greater populations of M . leprae are exposed to drug action.…”

Section: Subinmulation Techniquementioning

confidence: 99%

The Rate of Bactericidal Action of Rifampin on Mycobacterium leprae in the Mouse Footpad

Holmes

Hilson

1974

Experimental Biology and Medicine

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Continuous dietary administration of low dosages of 3-(4-methyl-1 -piperazinyl-iminomethyl) rifamycin (rifampin; RMP) inhibits the multiplication of Mycobacteriurn leprae in the mouse footpad (1, 2). The drug is highly bactericidal against M . Zeprae, as estimated by inoculation into mice of bacilli from lepromatous leprosy patients at intervals during treatment with 600 mg RMP daily (2), and by the kinetic technique of Shepard (3) in treated experimental animals (1, 4). Moreover, the lethal action of RMP, which is observed after exposure to drug for only 2 days, is far quicker than that of dapsone (4,4'-diaminodiphenylsulphone; DDS) which in mice can be detected only after administration for periods of 60 days or longer (3, 5 ) .

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Section: Subinmulation Techniquementioning

confidence: 99%

The Rate of Bactericidal Action of Rifampin on Mycobacterium leprae in the Mouse Footpad

Holmes

Hilson

1974

Experimental Biology and Medicine

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“…Similarly, it was long believed that only man was innately susceptible to M. leprae, but in the last 20 years it has been shown that appropriately infected rodents will support the limited replication of that organism (Shepard, 1960). The factor restricting in vivo replication is specific acquired immunity, and more extensive growth can be promoted by immunosuppressive procedures (Rees, 1966;Gaugas, 1968). The host range of M. lepraemurium (Mlm) appears to be limited to mice and rats, but critical studies have not been performed in other species (Fite, 1940).…”

Section: Species Susceptibilitymentioning

confidence: 99%

Immunopathology

1983

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“…However, a prolonged course of antilymphocytic globulin administered to thymectomized mice significantly enhanced susceptibility to M . Zeprae infection ( 7 ) .…”

mentioning

confidence: 99%

Effect of Neonatal Thymectomy and Antithymocytic Serum on Susceptibility of Rats to Mycobacterium leprae Infection

1971

Experimental Biology and Medicine

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The limited local infection induced in mice and rats after footpad inoculation with M . leprae (1)(2)(3) has led to the investigation of various methods of immunosuppression as a means of enhancing the infection.Mice thymectomized as adults and given whole-body irradiation (900 R, followed by infusion of syngeneic bone marrow) were substantially more susceptible to M . Zeprae infection than normal mice (4-6). Moreover, in these animals M . Zeprae spread systemically to remote sites in the body (4, 6). Neither adult thymectomy nor X-irradiation alone had a significant effect on the infection ( 5 ) . However, a prolonged course of antilymphocytic globulin administered to thymectomized mice significantly enhanced susceptibility to M . Zeprae infection ( 7 ) .Neonatal thymectomy alone in both mice and rats not only exerts a profound influence on subsequent immunologic responsiveness but also appears to accomplish, by more simple and direct means, the same type of impairment as that brought about by adult thymectomy accompanied by lethal irradiation or antilymphocytic serum (8,9). Neonatal thymectomy, however, is frequently followed by severe, fatal wasting disease, especially in mice (8-10).Rats are relatively resistant to wasting disease (9) and reportedly are as susceptible as the mouse to footpad infection with M . Zeprae (3). We have therefore investigated the course of M . Zeprae infec'tion in neonatally thymectomized rats, as well as the additional effect of antithymocytic serum (ATS) in these animals.

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Enhancing Effect of Antilymphocytic Globulin on Human Leprosy Infection in Thymectomized Mice

Cited by 28 publications

References 10 publications

The Rate of Bactericidal Action of Rifampin on Mycobacterium leprae in the Mouse Footpad

The Rate of Bactericidal Action of Rifampin on Mycobacterium leprae in the Mouse Footpad

Immunopathology

Effect of Neonatal Thymectomy and Antithymocytic Serum on Susceptibility of Rats to Mycobacterium leprae Infection

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