Enhancing effect of chlorinated organic solvents on histamine release and inflammatory mediator production

Seo, Makoto; Ikeda, Kazuhiko; Okamura, Tetsunori; Kida, Kumiko; Satoh, Masahiko; Inagaki, Nobuya; Nagai, Hiroichi; Nagase, Hisamitsu

doi:10.1016/j.tox.2007.09.024

Cited by 18 publications

(20 citation statements)

References 22 publications

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“…However, the pathogenesis of pollinosis is caused by the activation of mucosal mast cells; therefore, the enhancement of antigen-induced histamine release from BMMC by TCE and PCE is an important finding. In our in vivo studies, it was shown that a single intraperitoneal injection of TCE or PCE markedly enhanced the PCA reaction in ICR mice compared with Wistar rats (Seo et al, 2008a). Furthermore, the ingestion of a low concentration of TCE or PCE from drinking water also markedly enhanced the PCA reaction in ICR mice compared with Wistar rats (Seo et al, 2008b(Seo et al, , 2008c.…”

Section: Discussionmentioning

confidence: 65%

“…However, the immunotoxic effects of TCE and PCE are scarcely known. Previously, we reported the enhancing effects of TCE and PCE on antigen-induced allergic responses in vitro and in vivo using rats (Seo et al, 2008a(Seo et al, , 2008b(Seo et al, , 2008c. On the other hand, there have been no reports on the species differences in the enhancing effects of TCE and PCE on antigen-induced allergic responses.…”

Section: Introductionmentioning

confidence: 96%

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Enhancing effects of trichloroethylene and tetrachloroethylene on type I allergic responses in mice

et al. 2012

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-Trichloroethylene (TCE) and tetrachloroethylene (perchloroethylene; PCE) are commonly identified as environmental contaminants of groundwater. Previously, we investigated the enhancing effects of TCE and PCE on antigen-induced histamine release and inflammatory mediator production in rat mast cells. In this study, to examine the potential effect of TCE and PCE on antigen-induced histamine release from mouse mast cells, mouse bone marrow-derived mast cells (BMMC) were sensitized with anti-dinitrophenol (DNP) monoclonal IgE antibody and then stimulated with DNP-BSA containing with TCE or PCE. Both TCE and PCE significantly enhanced antigen-induced histamine release from BMMC. Next we investigated the effects of TCE and PCE on the passive cutaneous anaphylaxis (PCA) reaction in vivo using ICR mice. TCE and PCE significantly enhanced the PCA reaction in a dose-dependent manner. In addition, we examined the enhancing effects of ingesting small amount of TCE and PCE in drinking water on antigen-stimulated allergic responses. After the ICR mice had ingested TCE or PCE in their drinking water for 2 or 4 weeks, we performed the PCA reaction. Both TCE and PCE ingestion enhanced the PCA reaction in a dose-dependent manner for 4 weeks. These results suggest that exposure to TCE and PCE leads to the augmentation of type I allergic responses in many species.

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Section: Discussionmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 96%

Enhancing effects of trichloroethylene and tetrachloroethylene on type I allergic responses in mice

et al. 2012

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“…This lymphocytosis (and leukocytosis) seen in the peripheral blood could be due to paintinduced increases in histamine release/inflammatory mediator production from stimulated mast cells (secondary to other modulating events in painters' immune responses; Seo et al, 2008). Finotto et al (1991) found that exposure to toluene di-isocyanate (a componant of paint) induced an increase in the number of CD8 + lymphocytes and eosinophils, but no significant change in CD3 + levels.…”

Section: Discussionmentioning

confidence: 99%

Immunotoxicity and pulmonary toxicity induced by paints in Egyptian painters

Elgharabawy¹,

El-Maddah²,

Oreby³

et al. 2012

Journal of Immunotoxicology

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“…In animal experiments, TCE enhanced autoimmune responses, including activation of Th1 cells and inhibition of apoptosis of CD4 + T cells, in autoimmune-prone MRL +/+ mice (Blossom et al, 2008;Gilbert et al, 2006;Griffin et al, 2000aGriffin et al, , 2000b. In addition to these effects, we previously reported that TCE enhanced mast cell activation and subsequently caused immediate allergic reactions in rats (Seo et al, 2008a(Seo et al, , 2008b. More recently, we revealed that TCE exposure through drinking water promotes ovalbumin (OVA)-induced active cutaneous anaphylaxis (ACA), including enhancing OVA-specific serum IgE levels and splenic lymphocyte proliferation, in mice (Kobayashi et al, 2010).…”

Section: Introductionmentioning

confidence: 93%

Trichloroethylene enhances TCR-CD3-induced proliferation of CD8<sup>+</sup> rather than CD4<sup>+</sup> T cells

2012

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-Trichloroethylene (TCE) is suspected as a potent immunomodulator that accelerates the development of allergic diseases. We previously reported that TCE promotes ovalbumin (OVA)-induced active cutaneous anaphylaxis, including enhancing antigen-specific serum IgE levels and splenic lymphocyte proliferation. However, the target cells and molecular mechanism through which TCE modulates antigen-specific immune responses remain unclear. To identify a potential underlying mechanism, we investigated whether TCE modulates T cell receptor (TCR)-induced T cell activation and proliferation in vitro. TCE enhanced T cell proliferation primed by anti-CD3 antibody, but not concanavalin A, in a dose-dependent fashion. In addition, TCE enhanced anti-CD3-primed proliferation of CD8 + rather than CD4 + T cells. Consistent with this result, TCE markedly enhanced the Lck phosphorylation mediated by anti-CD3 antibody in CD8 + but not CD4 + T cells. Furthermore, we analyzed the effect of TCE exposure via drinking water for 2 weeks on splenocyte populations in non-immunized and OVA-immunized mice. In OVA-immunized mice, TCE (3 mg/l) significantly expanded CD3 + , CD8 + and CD4 + cell populations, however the effect at the lower concentration was significant only in the CD8 + populations, whereas TCE had no effect on these cells population in non-immunized mice. These findings suggest that TCE enhances TCR-CD3-induced proliferation of CD8 + rather than CD4 + cells and disrupts various activities of peripheral T cells.

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Enhancing effect of chlorinated organic solvents on histamine release and inflammatory mediator production

Cited by 18 publications

References 22 publications

Enhancing effects of trichloroethylene and tetrachloroethylene on type I allergic responses in mice

Enhancing effects of trichloroethylene and tetrachloroethylene on type I allergic responses in mice

Immunotoxicity and pulmonary toxicity induced by paints in Egyptian painters

Trichloroethylene enhances TCR-CD3-induced proliferation of CD8<sup>+</sup> rather than CD4<sup>+</sup> T cells

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