Enhancing effect of ultrasound on boron concentrations in an oral squamous cell carcinoma cell line SAS for boron neutron capture therapy

Yamamoto, Naofumi; Masunaga, Shin‐ichiro; Kato, Ikunoshin; Iwai, Shinichi; Nakazawa, Mitsuhiro; Ono, Koji; Yura, Yoshiaki

doi:10.1016/j.ajoms.2014.08.003

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…To establish BNCT in vitro efficacy experiment conditions, we measured the intracellular boron concentration by treating 500, 1000, and 2000 μg/mL of BPA in cells for 3 h. BPA is effluxed in cells within a short time in a medium without BPA [ 32 ]. For this reason, neutron irradiation is carried out in the presence of BPA in the medium [ 33 , 34 , 35 ]. Therefore, in order to maintain the intracellular BPA concentration, we used a medium containing BPA.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the neutron control survival fraction in the BNCT in vitro efficacy experiment is higher than the neutron control survival fraction in other BNCT experiments performed by other groups. We consider this to be due to the beam character of the reactor or accelerator of each BNCT experiment [ 33 , 48 , 49 , 50 ]. However, comparison of experimental results between BNCT groups is limited due to cells, tumor size at the time of irradiation, BPA concentration, neutron irradiation, and conditions.…”

Section: Discussionmentioning

confidence: 99%

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The Anti-Tumor Effect of Boron Neutron Capture Therapy in Glioblastoma Subcutaneous Xenograft Model Using the Proton Linear Accelerator-Based BNCT System in Korea

Seo¹,

Lee

Na³

et al. 2022

Life

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Boron neutron capture therapy (BNCT) is a radiation therapy that selectively kills cancer cells and is being actively researched and developed around the world. In Korea, development of the proton linear accelerator-based BNCT system has completed development, and its anti-cancer effect in the U-87 MG subcutaneous xenograft model has been evaluated. To evaluate the efficacy of BNCT, we measured 10B-enriched boronophenylalanine (BPA) uptake in U-87 MG, FaDu, and SAS cells and evaluated cell viability by clonogenic assays. In addition, the boron concentration in the tumor, blood, and skin on the U-87 MG xenograft model was measured, and the tumor volume was measured for 4 weeks after BNCT. In vitro, the intracellular boron concentration was highest in the order of SAS, FaDu, and U-87 MG, and cell survival fractions decreased depending on the BPA treatment concentration and neutron irradiation dose. In vivo, the tumor volume was significantly decreased in the BNCT group compared to the control group. This study confirmed the anti-cancer effect of BNCT in the U-87 MG subcutaneous xenograft model. It is expected that the proton linear accelerator-based BNCT system developed in Korea will be a new option for radiation therapy for cancer treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Anti-Tumor Effect of Boron Neutron Capture Therapy in Glioblastoma Subcutaneous Xenograft Model Using the Proton Linear Accelerator-Based BNCT System in Korea

Seo¹,

Lee

Na³

et al. 2022

Life

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The therapeutic effects on U87 and SAS cells using Proton Linac based Boron Neutron Capture Therapy in Korea

Seo¹,

Seo²,

Na³

et al. 2023

Applied Radiation and Isotopes

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Ultrasound‐stimulated microbubbles to enhance radiotherapy: A scoping review

McCorkell,

Piva,

Highgate

et al. 2024

J Med Imag Rad Onc

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IntroductionPrimarily used as ultrasound contrast agents, microbubbles have recently emerged as a versatile therapeutic vector that can be ‘burst’ to deliver payloads in the presence of suitably optimised ultrasound fields. Ultrasound‐stimulated microbubbles (USMB) have recently demonstrated improvements in treatment outcomes across a variety of clinical applications. This scoping review investigates whether this potential translates into the context of radiation therapy by evaluating the application of this technology across all three phases of radiation action.MethodsPrimary research articles, excluding poster presentations and conference proceedings, were identified through systematic searches of the PubMed NCBI/Medline, Embase/OVID, Web of Science and CINAHL/EBSCOhost databases, with additional articles identified via manual Google Scholar searching. Articles were dual screened for inclusion using the Covidence systematic review platform and classified against all three phases of radiation action.ResultsOverall, 57 eligible publications from a total of 1389 identified articles were included in the review, with studies dating back to 2012. Study heterogeneity prevented formal statistical analysis; however, most articles reported improved outcomes using USMB in the presence of radiation compared to that of radiation alone. These improvements appear to result from the use of USMB as either a biovascular disruptor causing tumour cell damage via indirect mechanisms, or as a localised treatment vector that directly increases tumour cell uptake of other therapeutic and physical agents designed to enhance radiation action.ConclusionsUSMB demonstrate exciting potential to enhance the effects of radiation treatments due to their versatility and capacity to target all three phases of radiation action.

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Enhancing effect of ultrasound on boron concentrations in an oral squamous cell carcinoma cell line SAS for boron neutron capture therapy

Cited by 4 publications

References 35 publications

The Anti-Tumor Effect of Boron Neutron Capture Therapy in Glioblastoma Subcutaneous Xenograft Model Using the Proton Linear Accelerator-Based BNCT System in Korea

The Anti-Tumor Effect of Boron Neutron Capture Therapy in Glioblastoma Subcutaneous Xenograft Model Using the Proton Linear Accelerator-Based BNCT System in Korea

The therapeutic effects on U87 and SAS cells using Proton Linac based Boron Neutron Capture Therapy in Korea

Ultrasound‐stimulated microbubbles to enhance radiotherapy: A scoping review

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