Enhancing Magnetic Hyperthermia Efficacy through Targeted Heat Shock Protein 90 Inhibition: Unveiling Immune-Mediated Therapeutic Synergy in Glioma Treatment

Gupta, Ruby; Chauhan, Anjali; Kaur, Tashmeen; Kuanr, Bijoy Kumar; Sharma, Deepika

doi:10.1021/acsnano.4c03887

ACS Nano

2024

DOI: 10.1021/acsnano.4c03887

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Enhancing Magnetic Hyperthermia Efficacy through Targeted Heat Shock Protein 90 Inhibition: Unveiling Immune-Mediated Therapeutic Synergy in Glioma Treatment

Ruby Gupta,

Anjali Chauhan,

Tashmeen Kaur

et al.

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Cited by 2 publications

References 67 publications

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Magnetic Hyperthermia in Glioblastoma Multiforme Treatment

Manescu (Paltanea),

Antoniac,

Paltanea

et al. 2024

IJMS

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Glioblastoma multiforme (GBM) represents one of the most critical oncological diseases in neurological practice, being considered highly aggressive with a dismal prognosis. At a worldwide level, new therapeutic methods are continuously being researched. Magnetic hyperthermia (MHT) has been investigated for more than 30 years as a solution used as a single therapy or combined with others for glioma tumor assessment in preclinical and clinical studies. It is based on magnetic nanoparticles (MNPs) that are injected into the tumor, and, under the effect of an external alternating magnetic field, they produce heat with temperatures higher than 42 °C, which determines cancer cell death. It is well known that iron oxide nanoparticles have received FDA approval for anemia treatment and to be used as contrast substances in the medical imagining domain. Today, energetic, efficient MNPs are developed that are especially dedicated to MHT treatments. In this review, the subject’s importance will be emphasized by specifying the number of patients with cancer worldwide, presenting the main features of GBM, and detailing the physical theory accompanying the MHT treatment. Then, synthesis routes for thermally efficient MNP manufacturing, strategies adopted in practice for increasing MHT heat performance, and significant in vitro and in vivo studies are presented. This review paper also includes combined cancer therapies, the main reasons for using these approaches with MHT, and important clinical studies on human subjects found in the literature. This review ends by describing the most critical challenges associated with MHT and future perspectives. It is concluded that MHT can be successfully and regularly applied as a treatment for GBM if specific improvements are made.

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Magnetic Hyperthermia in Glioblastoma Multiforme Treatment

Manescu (Paltanea),

Antoniac,

Paltanea

et al. 2024

IJMS

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Enhanced Synthesis of Copper Ferrite Magnetic Nanoparticles via Polymer-Assisted Sol-Gel Autocombustion Method for Magnetic Hyperthermia Applications

Mazurenko,

Kaykan,

Michalik

et al. 2024

JNanoR

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In this study, CuFe2O4 nanoparticles with an average crystallite size of approximately 10 nm were produced using the sol-gel autocombustion method. The synthesis was conducted in the presence of polymers with varying monomer counts, aiming to optimize the magnetic properties for possible localized magnetic heating applications. Comprehensive characterization of all samples was conducted using X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), and Mössbauer spectroscopy. All synthesized samples exhibited good colloidal stability, with zeta potentials around -18.49mV, +3mV and +24 to +30 mV. The Specific Absorption Rate (SAR) of the synthesized nanoparticles was assessed using the calorimetric method. The SAR values were calculated using both the Initial Slope and the Box-Lucas methods. For the sample synthesized using citric acid, the SAR values were 12.6 W/g and 13.23 W/g, respectively. For samples synthesized using polyethylene glycol, the SAR values ranged from 3 to 7 W/g. The parameters of the alternating magnetic field were 33.3 kA/m and 357 kHz.

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Enhancing Magnetic Hyperthermia Efficacy through Targeted Heat Shock Protein 90 Inhibition: Unveiling Immune-Mediated Therapeutic Synergy in Glioma Treatment

Cited by 2 publications

References 67 publications

Magnetic Hyperthermia in Glioblastoma Multiforme Treatment

Magnetic Hyperthermia in Glioblastoma Multiforme Treatment

Enhanced Synthesis of Copper Ferrite Magnetic Nanoparticles via Polymer-Assisted Sol-Gel Autocombustion Method for Magnetic Hyperthermia Applications

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