Enhancing monoamine oxidase B inhibitory activity via chiral fluorination: Structure-activity relationship, biological evaluation, and molecular docking study

Design and Enantioselective Synthesis of Chiral Pyranone Fused Indole Derivatives with Antibacterial Activities against Xanthomonas oryzae pv oryzae for Protection of Rice

“…On the other hand, the development and application of chiral pesticides are of increasing significance in modern crop protection. − Generally, only one single enantiomer is notably active against the target, while the other paired isomer is less or inactive, thus offering an ideal approach to reduce the excess use of chemical agents by the elimination of the less effective stereoisomer in the ingredients. , For example, the herbicidal action of metolachlor as developed by Syngenta is mainly attributed to the S -configured single enantiomer, while its opposite stereoisomer, R -metolachlor is basically inactive and displays notable toxicity (10 times higher than S -metolachlor). , An et al found that 1 S, 4 R -(−)-benzovindiflupyr, a widely used commercial fungicide, exhibited 1.7–54.5 times greater activity against six specific phytopathogens compared to the other enantiomer 1 R, 4 S -(+)-benzovindiflupyr (Figure A) . According to recent statistical data, approximately 44% of registered agrochemicals feature at least one stereogenic element, and the number of chiral pesticides continues to increase dramatically every year .…”