The contemporary work delineates the photocatalytic and antibacterial activity of Titanium (Ti) and Lanthanum (La) doped Cadmium Selenide (CdSe) nanoparticles produced by a simple wet‐chemical method. Studies using diffraction and microscopy revealed that the synthesized samples devised cubic crystalline structure. The incorporation of the dopant into the host material are analyzed using XRD, SEM‐EDAX and TEM studies. The photocatalytic activity Ti and La doped CdSe nanoparticles resulted in improved degradation towards methylene blue (MB) dye under direct solar irradiation. This unique behavior is ascribed to the enhanced light absorption tendency with larger charge separation efficiency. Ongoing operational factors like initial dye concentration, catalyst dose, pH, and duration were evaluated regarding their effects on MB dye degradation. The photocatalytic activity for MB was followed pseudo‐first order kinetics. The antibacterial activity of Ti‐ and La‐metal doped CdSe was tested against Pseudomonas Arueginosa and Staph Aureus bacteria. The Ti‐CdSe and La‐CdSe nanoparticles showed an good antibacterial activity after 24 hours of bacterial growth Pseudomonas Arueginosa and Staph Aureus, respectively. Based on our findings, Ti‐CdSe and La‐CdSe nanoparticles exhibit an enhanced photocatalytic and antibacterial activity when compared with CdSe nanoparticles.This article is protected by copyright. All rights reserved.