“…With this as a caveat, the majority of studies of MSC chondrogenesis either in pellet or scaffold cultures indicates an increase in chondrogenic genes ( COL2A1 and ACAN ) and matrix formation under physioxia [33,41,42,43,47,49,50,52,55,62,71,72,76,77,78,79,82,86,87,88,90,92,93,95,97]. Furthermore, it has also been shown that physioxia is a more potent promoter of chondrogenesis than dynamic (compressive) loading with no synergistic effect upon combining the parameters [78,98].…”