Enhancing Safety via Medication Self-Management and Timely Reporting

Jiang, Yun; Gong, Yang

doi:10.3233/shti210773

Cited by 5 publications

(2 citation statements)

References 11 publications

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“…Capturing individual dynamic responses to OAA treatment is critical for the development of personalized interventions [ 34 , 36 ]. Therefore, it is important to assess older adults’ OAA treatment tolerability in a timely fashion and monitor for early signs and symptoms of toxicities from home [ 37 ], to intervene early to prevent the development of severe side effects and improve patient safety and health outcomes [ 16 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Tolerance to oral anticancer agent treatment in older adults with cancer: a secondary analysis of data from electronic health records and a pilot study of patient-reported outcomes

et al. 2022

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Background More than 60% of cancer cases occur in older adults, and many are treated with oral anticancer agents. Yet, the treatment tolerability in older adults has not been fully understood due to their underrepresentation in oncology clinical trials, creating challenges for treatment decision-making and symptom management. The objective of this study was to investigate the tolerance of capecitabine, an example of oral chemotherapy, among older adults with cancer and explore factors associated with capecitabine-related side effects and treatment changes, to enhance supportive care. Methods A secondary analysis used combined data from electronic health records and a pilot study of patient-reported outcomes, with a total of 97 adult patients taking capecitabine during 2016–2017, including older adult patients aged 65 years or older (n = 43). The data extracted included patient socio-demographics, capecitabine information, side effects, and capecitabine treatment changes (dose reductions and dose interruptions). Bivariate correlations, negative binomial regression, and multiple linear regression were conducted for data analysis. Results Older adults were more likely to experience fatigue (86% vs. 51%, p = .001) and experienced more severe fatigue (β = 0.44, p = 0.03) and hand-foot syndrome (HFS) (β = 1.15, p = 0.004) than younger adults. The severity of fatigue and HFS were associated with the number of outpatient medications (β = 0.06, p = 0.006) and the duration of treatment (β = 0.50, p = 0.009), respectively. Correlations among side effects presented different patterns between younger and older adults. Although more older adults experienced dose reductions (21% vs. 13%) and dose interruptions (33% vs. 28%) than younger adults, the differences were not statistically different. Female sex, breast cancer diagnosis, capecitabine monotherapy, and severe HFS were found to be associated with dose reductions (p-values < 0.05). Conclusions Older adults were less likely to tolerate capecitabine treatment and had different co-occurring side effects compared to younger adults. While dose reductions are common among older adults, age 65 years or older may not be an independent factor of treatment changes. Other socio-demographic and clinical factors may be more likely to be associated. Future studies can be conducted to further explore older adults’ tolerance to a variety of oral anticancer agents to generate more evidence to support optimal treatment decision-making and symptom management.

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Section: Discussionmentioning

confidence: 99%

Tolerance to oral anticancer agent treatment in older adults with cancer: a secondary analysis of data from electronic health records and a pilot study of patient-reported outcomes

et al. 2022

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“…In an observational study, the occurrence of adverse medication events in oncology patients taking OAAs was as high as 87.36% [4]. As some of the severe side effects can be di cult to manage for patients and their families at home, personalized patient education and guidance and effective patient-clinician communications are essential for improving patient outcomes and safety [5]. To achieve the goal of medication safety during TOC, patients with cancer and their families need to become "vigilant partners" in medication and toxicity self-monitoring, including timely reporting of their medication safety events or concerns to clinicians [6].…”

Section: Introductionmentioning

confidence: 99%

Oncology patients’ willingness to report their medication safety concerns from home: a qualitative study

Bunni,

Walters,

Hwang

et al. 2024

Support Care Cancer

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Oncology patients often struggle in managing their oral anticancer agents and related adverse events during transitions of care. They are expected to take an active role in self-monitoring and timely reporting of their medication safety events or concerns to clinicians. The purpose of this study was to explore the factors in uencing oncology patients' willingness to report these adverse events after their transitions back home. Methods:A qualitative interview study was conducted with adult patients with breast, prostate, lung, or colorectal cancer who experienced care transitions within the previous year. A semi-structured interview guide was developed to understand patients' perceptions of reporting mediation-related safety events or concerns from home. All interviews were conducted via phone calls, recorded, and transcribed for thematic data analysis. Results:A total of 41 individuals participated in the interviews. Three main themes and six subthemes emerged, including patients' perceived relationship with clinicians (the quality of communication and trust in clinicians), perceived severity of adverse medication events (perceived severe vs. non-severe events), and patient activation in self-management (self-e cacy in self-management and engagement in monitoring health outcomes). Conclusion:The patient-clinician relationship signi cantly in uenced patients' reporting behaviors, which can potentially interact with other factors, including the severity of adverse events. It is important to engage oncology patients in medication safety reporting from home by enhancing health communication, understanding patients' perceptions of severe events, and promoting patient activation. By addressing these efforts, healthcare providers should adopt a more patient-centered approach to enhance the overall quality and safety of oncological care.

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Oncology patients’ willingness to report their medication safety concerns from home: A qualitative study

Bunni,

Walters,

Hwang

et al. 2024

Preprint

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Purpose: Oncology patients often struggle in managing their oral anticancer agents and related adverse events during transitions of care. They are expected to take an active role in self-monitoring and timely reporting of their medication safety events or concerns to clinicians. The purpose of this study was to explore the factors influencing oncology patients' willingness to report these adverse events after their transitions back home.Methods: A qualitative interview study was conducted with adult patients with breast, prostate, lung, or colorectal cancer who experienced care transitions within the previous year. A semi-structured interview guide was developed to understand patients’ perceptions of reporting mediation-related safety events or concerns from home. All interviews were conducted via phone calls, recorded, and transcribed for thematic data analysis.Results: A total of 41 individuals participated in the interviews. Three main themes and six subthemes emerged, including patients’ perceived relationship with clinicians (the quality of communication and trust in clinicians), perceived severity of adverse medication events (perceived severe vs. non-severe events), and patient activation in self-management (self-efficacy in self-management and engagement in monitoring health outcomes).Conclusion: The patient-clinician relationship significantly influenced patients' reporting behaviors, which can potentially interact with other factors, including the severity of adverse events. It is important to engage oncology patients in medication safety reporting from home by enhancing health communication, understanding patients’ perceptions of severe events, and promoting patient activation. By addressing these efforts, healthcare providers should adopt a more patient-centered approach to enhance the overall quality and safety of oncological care.

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Enhancing Safety via Medication Self-Management and Timely Reporting

Cited by 5 publications

References 11 publications

Tolerance to oral anticancer agent treatment in older adults with cancer: a secondary analysis of data from electronic health records and a pilot study of patient-reported outcomes

Tolerance to oral anticancer agent treatment in older adults with cancer: a secondary analysis of data from electronic health records and a pilot study of patient-reported outcomes

Oncology patients’ willingness to report their medication safety concerns from home: a qualitative study

Oncology patients’ willingness to report their medication safety concerns from home: A qualitative study

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