Enhancing sealing of fetal membrane defects using tissue engineered native amniotic scaffolds in the rabbit model

Ochsenbein‐Kölble, Nicole; Jani, Jacques; Lewi, Liesbeth; Verbist, Godelieve; Vercruysse, Lisbeth; Portmann-Lanz, Bettina; Marquardt, Klaus; Zimmermann, Roland; Deprest, Jan

doi:10.1016/j.ajog.2006.10.904

Cited by 41 publications

(28 citation statements)

References 25 publications

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“…Although some endogenous cells were recruited to the matrix plug during the postoperative phase of the experiment, the sealing of the fetal membrane mainly relied on closure of the puncture site by the plug (Mallik et al, 2007, Ochsenbein-Kolble et al, 2007. The limited healing capacity of fetal membranes and the instability of plugging materials might limit the practicality of these approaches.…”

Section: Introductionmentioning

confidence: 99%

“…Attempts to seal the fetoscopic entry site by collagen scaffolds might be limited by the stability of the matrix, resulting in a lack of long-term stability. Based on the hypothesis that cell instructive scaffolds can induce a biological repair, decellularized amnion tissue was evaluated in a rabbit gestational model (Mallik et al, 2007, Ochsenbein-Kolble et al, 2007.…”

Section: Introductionmentioning

confidence: 99%

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Mussel‐mimetic tissue adhesive for fetal membrane repair: a standardized ex vivo evaluation using elastomeric membranes

et al. 2011

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ObjectiveIatrogenic preterm premature rupture of membranes (iPPROM), the main complication of invasive interventions in the prenatal period, seriously limits the benefit of diagnostic or surgical prenatal procedures. This study aimed to evaluate preventive plugging of punctured fetal membranes in an ex vivo situation using a new mussel‐mimetic tissue adhesive (mussel glue) to inhibit leakage.MethodsA novel biomechanical test device that tests the closure of injured membranes under near‐physiological conditions was used. Mussel glue, a poly(ethylene glycol)‐based hydrogel, was used to seal membrane defects of up to 3 mm in mechanically well‐defined elastomeric membranes with three different degrees of stiffness.ResultsElastomeric test membranes were successfully employed for testing mussel glue under well‐defined conditions. Mussel glue plugs were distended by up to 94%, which translated to an improved sealing efficiency on elastomeric membranes with high stiffness. For the stiffest membrane tested, a critical burst pressure of 48 mbar (36 mmHg) was accomplished in this ex vivo setting.ConclusionsMussel glue appears to efficiently seal membrane defects under well‐standardized ex vivo conditions. As repaired membranes resist pressures measured in amniotic cavities, mussel glue might represent a novel sealing method for iatrogenic membrane defects. Copyright © 2011 John Wiley & Sons, Ltd.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mussel‐mimetic tissue adhesive for fetal membrane repair: a standardized ex vivo evaluation using elastomeric membranes

et al. 2011

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“…Because of the clinical relevance of its consequences, several groups have explored the possibility to treat or prevent iPPROM from happening by sealing the membrane defect. Most research now focuses on using matrices that may improve sealing and stimulate wound healing (Lewi et al, 2004;Mallik et al, 2007;Ochsenbein-Kolble et al, 2007).…”

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confidence: 99%

On the origin of amniotic stem cells: of mice and men

Dobreva¹,

Pereira²,

Deprest³

et al. 2010

Int. J. Dev. Biol.

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A common characteristic of mammals is the development of extraembryonic supporting tissues and organs that are required for embryonic implantation, survival and development in utero. The amnion is the innermost extraembryonic membrane that eventually surrounds the fetus of amniotes, and contains the amniotic fluid. Next to its function in in utero development, the amnion has been shown to have an important potential for clinical applications. It is mainly used as a dressing to stimulate healing in skin and ocular wounds. Moreover, cells derived from the amniotic membrane and amniotic fluid have been reported to possess stem cell features, like pluripotent differentiation ability. Little is known about the early development of this membrane in humans. The mouse is a powerful genetic model organism that can be used to address the dynamics and the developmental origin of amnion and amnion-derived stem cells. Here, we discuss some fundamental differences in amnion development in the disc-shaped primate embryo and in the cup-shaped mouse embryo. We emphasize the consequences that this may have on the derivation of amniotic "stem" cells. After revision of the different isolation procedures of amniotic (fluid) derived "stem" cells from rodents, we reveal striking differences in the sources used to derive these cells across studies. The profound differences in the development of the extraembryonic membranes and cavities between primates and rodents may result in comparing cell types of different developmental origins, eventually leading to missinterpretations.

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“…Fauza et al (2001) already suggested this 10 years ago, hoping this would create a more functional substitute than the inert synthetic grafts currently in use (Kunisaki et al, 2006). These strategies may also be used to create a matrix for stimulating fetal membrane healing (Ochsenbein-Köble et al, 2007;Mallik et al, 2007).…”

Section: The Futurementioning

confidence: 99%

The making of fetal surgery

et al. 2010

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Fetal diagnosis prompts the question for fetal therapy in highly selected cases. Some conditions are suitable for in utero surgical intervention. This paper reviews historically important steps in the development of fetal surgery. The first invasive fetal intervention in 1963 was an intra-uterine blood transfusion. It took another 20 years to understand the pathophysiology of other candidate fetal conditions and to develop safe anaesthetic and surgical techniques before the team at the University of California at San Francisco performed its first urinary diversion through hysterotomy. This procedure would be abandoned as renal and pulmonary function could be just as effectively salvaged by ultrasound-guided insertion of a bladder shunt. Fetoscopy is another method for direct access to the feto-placental unit. It was historically used for fetal visualisation to guide biopsies or for vascular access but was also abandoned following the introduction of high-resolution ultrasound. Miniaturisation revived fetoscopy in the 1990s, since when it has been successfully used to operate on the placenta and umbilical cord. Today, it is also used in fetuses with congenital diaphragmatic hernia (CDH), in whom lung growth is triggered by percutaneous tracheal occlusion. It can also be used to diagnose and treat urinary obstruction. Many fetal interventions remain investigational but for a number of conditions randomised trials have established the role of in utero surgery, making fetal surgery a clinical reality in a number of fetal therapy programmes. The safety of fetal surgery is such that even non-lethal conditions, such as myelomeningocoele repair, are at this moment considered a potential indication. This, as well as fetal intervention for CDH, is currently being investigated in randomised trials.

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Enhancing sealing of fetal membrane defects using tissue engineered native amniotic scaffolds in the rabbit model

Cited by 41 publications

References 25 publications

Mussel‐mimetic tissue adhesive for fetal membrane repair: a standardized ex vivo evaluation using elastomeric membranes

Mussel‐mimetic tissue adhesive for fetal membrane repair: a standardized ex vivo evaluation using elastomeric membranes

On the origin of amniotic stem cells: of mice and men

The making of fetal surgery

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