Blockchain is a promising technology that can help organizations improve their cybersecurity. Blockchain has many inherent features that can help enhance data security, improve threat detection and response, strengthen authentication and authorization, and enhance cyber threat intelligence sharing. This is possible because of the innovative approach that Blockchain uses, such as immutable ledgers to store transactions, monitor assets, and build trust by providing access only to authorized participants. The chapter discusses cybersecurity best practices related to smart contracts, key management, network security, user education and awareness, incident reporting, privacy challenges, software updates, and decentralization. Key regulatory compliance aspects, such as GDPR and HIPPA, are discussed. The increasing interactions of Artificial Intelligence (AI), Machine Learning (ML), and the Internet of Things (IoT) with Blockchain can further provide improved cybersecurity services and hence form the discussion of the trends and potential future research section of this chapter.