Enhancing spinal cord stimulation-induced pain inhibition by augmenting endogenous adenosine signalling after nerve injury in rats

Cui, Xiang; Liu, Jing; Uniyal, Ankit; Xu, Qian; Zhang, Chi; Zhu, Guangwu; Yang, Fei; Sivanesan, Eellan; Linderoth, Bengt; Raja, Srinivasa N.; Guan, Yun

doi:10.1016/j.bja.2024.01.005

Cited by 5 publications

(2 citation statements)

References 37 publications

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“…IL-10 is secreted by T and B cells, monocytes, macrophages, and epithelial cells [62]. Studies have demonstrated that acute administration of IL-10 can inhibit the onset of spinally mediated pain enhancement in various animal models, including peripheral neuritis, spinal cord excitotoxic injury, and peripheral nerve injury [63][64][65]. Conversely, blocking spinal IL-10 has been shown to prevent and even reverse established neuropathic pain behaviors [63][64][65].…”

Section: Interleukin-10 (Il-10)mentioning

confidence: 99%

“…Studies have demonstrated that acute administration of IL-10 can inhibit the onset of spinally mediated pain enhancement in various animal models, including peripheral neuritis, spinal cord excitotoxic injury, and peripheral nerve injury [63][64][65]. Conversely, blocking spinal IL-10 has been shown to prevent and even reverse established neuropathic pain behaviors [63][64][65]. IL-10 has the potential to interfere with neutrophil function, which plays an essential role in moderating systemic inflammation [62].…”

Section: Interleukin-10 (Il-10)mentioning

confidence: 99%

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Interactions and Trends of Interleukins, PAI-1, CRP, and TNF-α in Inflammatory Responses during the Perioperative Period of Joint Arthroplasty: Implications for Pain Management—A Narrative Review

Cocea,

Stoica

2024

JPM

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Inflammation during the perioperative period of joint arthroplasty is a critical aspect of patient outcomes, influencing both the pathophysiology of pain and the healing process. This narrative review comprehensively evaluates the roles of specific cytokines and inflammatory biomarkers in this context and their implications for pain management. Inflammatory responses are initiated and propagated by cytokines, which are pivotal in the development of both acute and chronic postoperative pain. Pro-inflammatory cytokines play essential roles in up-regulating the inflammatory response, which, if not adequately controlled, leads to sustained pain and impaired tissue healing. Anti-inflammatory cytokines work to dampen inflammatory responses and promote resolution. Our discussion extends to the genetic and molecular influences on cytokine production, which influence pain perception and recovery rates post-surgery. Furthermore, the role of PAI-1 in modulating inflammation through its impact on the fibrinolytic system highlights its potential as a therapeutic target. The perioperative modulation of these cytokines through various analgesic and anesthetic techniques, including the fascia iliac compartment block, demonstrates a significant reduction in pain and inflammatory markers, thus underscoring the importance of targeted therapeutic strategies. Our analysis suggests that a nuanced understanding of the interplay between pro-inflammatory and anti-inflammatory cytokines is required. Future research should focus on individualized pain management strategies.

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Section: Interleukin-10 (Il-10)mentioning

confidence: 99%

Section: Interleukin-10 (Il-10)mentioning

confidence: 99%

Interactions and Trends of Interleukins, PAI-1, CRP, and TNF-α in Inflammatory Responses during the Perioperative Period of Joint Arthroplasty: Implications for Pain Management—A Narrative Review

Cocea,

Stoica

2024

JPM

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Neuropathic Pain Induced by Spinal Cord Injury from the Glia Perspective and Its Treatment

Ye,

Su,

Tang

et al. 2024

Cell Mol Neurobiol

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Visualizing the modulation of neurokinin 1 receptor–positive neurons in the superficial dorsal horn by spinal cord stimulation in vivo

Xu,

Zheng,

Cui

et al. 2024

Pain

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Spinal cord stimulation (SCS) is an effective modality for pain treatment, yet its underlying mechanisms remain elusive. Neurokinin 1 receptor–positive (NK1R+) neurons in spinal lamina I play a pivotal role in pain transmission. To enhance our mechanistic understanding of SCS-induced analgesia, we investigated how different SCS paradigms modulate the activation of NK1R+ neurons, by developing NK1R-Cre;GCaMP6s transgenic mice and using in vivo calcium imaging of superficial NK1R+ neurons under anesthesia (1.5% isoflurane). Neurokinin 1 receptor–positive neurons in the lumbar spinal cord (L4-5) showed a greater activation by electrical test stimulation (TS, 3.0 mA, 1 Hz) at the hindpaw at 2 weeks after tibia-sparing nerve injury (SNI-t) than in naïve mice. Spinal cord stimulation was then delivered through a bipolar plate electrode placed epidurally at L1-2 level. The short-term 50-Hz high-intensity SCS (80% motor threshold [MoT], 10 minutes) induced robust and prolonged inhibition of NK1R+ neuronal responses to TS in both naïve and SNI-t mice. The 30-minute 50-Hz and 900-Hz SCS applied at moderate intensity (50% MoT) also significantly inhibited neuronal responses in SNI-t mice. However, at low intensity (20% MoT), the 30-minute 900-Hz SCS only induced persistent neuronal inhibition in naïve mice, but not in SNI-t mice. In conclusion, both 10-minute high-intensity SCS and 30-minute SCS at moderate intensity inhibit the activation of superficial NK1R+ neurons, potentially attenuating spinal nociceptive transmission. Furthermore, in vivo calcium imaging of NK1R+ neurons provides a new approach for exploring the spinal neuronal mechanisms of pain inhibition by neuromodulation pain therapies.

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Enhancing spinal cord stimulation-induced pain inhibition by augmenting endogenous adenosine signalling after nerve injury in rats

Cited by 5 publications

References 37 publications

Interactions and Trends of Interleukins, PAI-1, CRP, and TNF-α in Inflammatory Responses during the Perioperative Period of Joint Arthroplasty: Implications for Pain Management—A Narrative Review

Interactions and Trends of Interleukins, PAI-1, CRP, and TNF-α in Inflammatory Responses during the Perioperative Period of Joint Arthroplasty: Implications for Pain Management—A Narrative Review

Neuropathic Pain Induced by Spinal Cord Injury from the Glia Perspective and Its Treatment

Visualizing the modulation of neurokinin 1 receptor–positive neurons in the superficial dorsal horn by spinal cord stimulation in vivo

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