The extant literature does not provide consolidated knowledge on the use of Industry 4.0 in supply chains of emerging markets. This systematic literature review investigated the benefits, use, challenges, and mitigation measures related to Industry 4.0 technologies in supply chain management within thirteen “major emerging markets”. Industry 4.0 integrates technologies such as the Internet of Things (IoT), big data analytics, and cloud computing, and it offers tangible benefits for manufacturing and supply chains. However, its adoption faces significant obstacles, particularly in emerging economies. This study used the PSALSAR framework and PRISMA methodology to systematically review 87 peer-reviewed research articles on Industry 4.0 in the supply chain context of thirteen major emerging economies. Findings revealed that while IoT, big data, and artificial intelligence are frequently applied, other technologies such as cloud computing and robotics are underutilized. Key challenges identified include data integration, cyber-security, high upfront investment, weak policy, and business risks. Mitigation strategies proposed include the development of supportive policies, management backing, training, and improved data security. Tangible benefits such as sustainably using resources, reducing power use, enabling collaboration among supply chain partners, incorporating asset traceability, and minimizing meat contamination were evident. This research provides useful insights into the current status of Industry 4.0 adoption in emerging markets, helping stakeholders to navigate towards a more digitized, efficient future.